Antiproliferative Effects of the Triterpene Ursolic Acid Natural Product in Bladder and Ovarian Tumor Cell Lines
Sign Up to like & getrecommendations! Published in 2025 at "Drug Development Research"
DOI: 10.1002/ddr.70172
Abstract: Bladder and ovarian cancers impose a significant burden on healthcare systems due to their high incidence, mortality rates, and the challenges associated with early diagnosis. Current chemotherapy regimens, which typically involve combinations of drugs, often… read more here.
Keywords: ursolic acid; cell lines; bladder ovarian; cell ... See more keywords
Fluorescent organometallic rhodium(I) and ruthenium(II) metallodrugs with 4-ethylthio-1,8-naphthalimide ligands: Antiproliferative effects, cellular uptake and DNA-interaction.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.06.056
Abstract: Fluorescent 4-ethylthio-1,8-naphthalimides containing rhodium(I) N-heterocyclic carbene (NHC) and ruthenium (II) NHC fragments were synthesised and evaluated for their antiproliferative effects, cellular uptake and DNA-binding activity. Both types of organometallics triggered ligand dependent efficient cytotoxic effects… read more here.
Keywords: effects cellular; dna; fluorescent; antiproliferative effects ... See more keywords
Antiproliferative effects of zerumbone-pendant derivatives on human T-cell lymphoid cell line Jurkat cells
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron"
DOI: 10.1016/j.tet.2019.01.038
Abstract: Abstract Zerumbone is the major component of the essential oil of wild ginger, Zingiber zerumbet Smith. It is not only highly reactive but also has diverse bioactivities. Those effects derive from two conjugated double bonds… read more here.
Keywords: pendant derivatives; zerumbone pendant; antiproliferative effects; effects zerumbone ... See more keywords
Arylacetamides exhibit antiproliferative effects on non-transformed mammalian and vegetal cells and toxicity on crustaceans and fish embryos
Sign Up to like & getrecommendations! Published in 2025 at "Drug and Chemical Toxicology"
DOI: 10.1080/01480545.2025.2492770
Abstract: Abstract Non-clinical steps for development, validation and biosafety of new medicines and products comprises studies on cells, proteins, and animals. Herein, we evaluated the toxic activity of antitumoral 2-chloro-N-arylacetamides on eukaryotic dividing cells and animal… read more here.
Keywords: vegetal cells; exhibit antiproliferative; toxicity; antiproliferative effects ... See more keywords
Secondary metabolites with antiproliferative effects from Albizia glaberrima var glabrescens Oliv. (Mimosoideae)
Sign Up to like & getrecommendations! Published in 2017 at "Natural Product Research"
DOI: 10.1080/14786419.2016.1269097
Abstract: Abstract A new 5-dehydroxyflavan, namely Albiziaflavan B or (+)-(2R, 3S, 4R)-3′,4′, 7-trihydroxy-4-methoxy-2,3-trans-flavan-3,4-trans-diol (1) was isolated from the root bark of Albizia glaberrima, together with six known compounds including three flavans: (+)-mollisacacidin (2), (+)-fustin (3) and… read more here.
Keywords: metabolites antiproliferative; glaberrima var; albizia glaberrima; effects albizia ... See more keywords
Antioxidant and antiproliferative effects of Teucrium polium extract: computational and in vivo study in rats
Sign Up to like & getrecommendations! Published in 2024 at "Toxicology Mechanisms and Methods"
DOI: 10.1080/15376516.2023.2301670
Abstract: Abstract The current study aimed to assess the antioxidant and antiproliferative effects of teucrium polium extract: computational and in vivo study in rats. Three groups of animals: Group (i) constitute the control group; Group (ii)… read more here.
Keywords: effects teucrium; group; polium; antioxidant antiproliferative ... See more keywords
Antiproliferative effects of two gold(I)-N-heterocyclic carbene complexes in A2780 human ovarian cancer cells: a comparative proteomic study
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25556
Abstract: Au(NHC) and Au(NHC)2, i.e. a monocarbene gold(I) complex and the corresponding bis(carbene) complex, are two structurally related compounds, endowed with cytotoxic properties against several cancer cell lines. Herein, we explore the molecular and cellular mechanisms… read more here.
Keywords: a2780 human; carbene; ovarian cancer; human ovarian ... See more keywords
Investigation of TNBC in vitro Antiproliferative Effects of Versatile Pirrolo[1,2-a]quinoxaline Compounds
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2019.00012
Abstract: The triple-negative breast cancer (TNBC) is characterized by a more aggressive nature and poorer prognosis, nowadays none pharmaceutical approach is still available. For this reason, the research of new active compounds and attractive targets represents… read more here.
Keywords: vitro antiproliferative; versatile pirrolo; effects versatile; tnbc vitro ... See more keywords
Concomitant inhibition of PI3K/mTOR signaling pathways boosts antiproliferative effects of lanreotide in bronchopulmonary neuroendocrine tumor cells
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2024.1308686
Abstract: Introduction: Somatostatin analogues (SSAs) are commonly used in the treatment of hormone hypersecretion in neuroendocrine tumors (NETs), however the extent to which they inhibit proliferation is much discussed. Objective: We studied the antiproliferative effects of… read more here.
Keywords: nci h720; lanreotide bronchopulmonary; antiproliferative effects; mtor ... See more keywords
SIRT3 and Metabolic Reprogramming Mediate the Antiproliferative Effects of Whey in Human Colon Cancer Cells
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13205196
Abstract: Simple Summary Colorectal cancer (CRC) is the second leading cause of cancer-related deaths and the most frequently diagnosed cancer type. CRC risk can be preventable by modifiable risk factors, including diet. This study provides evidence… read more here.
Keywords: ppar; effects whey; crc; cancer ... See more keywords
Antiproliferative Effects of the Aptamer d(GGGT)4 and Its Analogues with an Abasic-Site Mimic Loop on Different Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23115952
Abstract: In this paper, we study the T30923 antiproliferative potential and the contribution of its loop residues in six different human cancer cell lines by preparing five T30923 variants using the single residue replacement approach of… read more here.
Keywords: cell; site mimic; antiproliferative effects; abasic site ... See more keywords