Fluorescent organometallic rhodium(I) and ruthenium(II) metallodrugs with 4-ethylthio-1,8-naphthalimide ligands: Antiproliferative effects, cellular uptake and DNA-interaction.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.06.056
Abstract: Fluorescent 4-ethylthio-1,8-naphthalimides containing rhodium(I) N-heterocyclic carbene (NHC) and ruthenium (II) NHC fragments were synthesised and evaluated for their antiproliferative effects, cellular uptake and DNA-binding activity. Both types of organometallics triggered ligand dependent efficient cytotoxic effects… read more here.
Keywords: effects cellular; dna; fluorescent; antiproliferative effects ... See more keywords
Antiproliferative effects of zerumbone-pendant derivatives on human T-cell lymphoid cell line Jurkat cells
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron"
DOI: 10.1016/j.tet.2019.01.038
Abstract: Abstract Zerumbone is the major component of the essential oil of wild ginger, Zingiber zerumbet Smith. It is not only highly reactive but also has diverse bioactivities. Those effects derive from two conjugated double bonds… read more here.
Keywords: pendant derivatives; zerumbone pendant; antiproliferative effects; effects zerumbone ... See more keywords
Secondary metabolites with antiproliferative effects from Albizia glaberrima var glabrescens Oliv. (Mimosoideae)
Sign Up to like & getrecommendations! Published in 2017 at "Natural Product Research"
DOI: 10.1080/14786419.2016.1269097
Abstract: Abstract A new 5-dehydroxyflavan, namely Albiziaflavan B or (+)-(2R, 3S, 4R)-3′,4′, 7-trihydroxy-4-methoxy-2,3-trans-flavan-3,4-trans-diol (1) was isolated from the root bark of Albizia glaberrima, together with six known compounds including three flavans: (+)-mollisacacidin (2), (+)-fustin (3) and… read more here.
Keywords: metabolites antiproliferative; glaberrima var; albizia glaberrima; effects albizia ... See more keywords
Antiproliferative effects of two gold(I)-N-heterocyclic carbene complexes in A2780 human ovarian cancer cells: a comparative proteomic study
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25556
Abstract: Au(NHC) and Au(NHC)2, i.e. a monocarbene gold(I) complex and the corresponding bis(carbene) complex, are two structurally related compounds, endowed with cytotoxic properties against several cancer cell lines. Herein, we explore the molecular and cellular mechanisms… read more here.
Keywords: a2780 human; carbene; ovarian cancer; human ovarian ... See more keywords
Investigation of TNBC in vitro Antiproliferative Effects of Versatile Pirrolo[1,2-a]quinoxaline Compounds
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2019.00012
Abstract: The triple-negative breast cancer (TNBC) is characterized by a more aggressive nature and poorer prognosis, nowadays none pharmaceutical approach is still available. For this reason, the research of new active compounds and attractive targets represents… read more here.
Keywords: vitro antiproliferative; versatile pirrolo; effects versatile; tnbc vitro ... See more keywords
SIRT3 and Metabolic Reprogramming Mediate the Antiproliferative Effects of Whey in Human Colon Cancer Cells
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13205196
Abstract: Simple Summary Colorectal cancer (CRC) is the second leading cause of cancer-related deaths and the most frequently diagnosed cancer type. CRC risk can be preventable by modifiable risk factors, including diet. This study provides evidence… read more here.
Keywords: ppar; effects whey; crc; cancer ... See more keywords
Antiproliferative Effects of the Aptamer d(GGGT)4 and Its Analogues with an Abasic-Site Mimic Loop on Different Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23115952
Abstract: In this paper, we study the T30923 antiproliferative potential and the contribution of its loop residues in six different human cancer cell lines by preparing five T30923 variants using the single residue replacement approach of… read more here.
Keywords: cell; site mimic; antiproliferative effects; abasic site ... See more keywords
Antiproliferative Effects of Cynara Cardunculus in Colorectal Cancer Cells Are Modulated by the Circadian Clock
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23169130
Abstract: The circadian clock generates 24 h rhythms in behavioural, cellular and molecular processes. Malfunctions of the clock are associated with enhanced susceptibility to cancer, worse treatment response and poor prognosis. Clock-controlled genes are involved in… read more here.
Keywords: circadian clock; cynara cardunculus; antiproliferative effects; clock ... See more keywords
The Antiproliferative Effects of Flavonoid MAO Inhibitors on Prostate Cancer Cells
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DOI: 10.3390/molecules25092257
Abstract: Prostate cancer (PCa) patients commonly experience clinical depression. Recent reports indicated that monoamine oxidase-A (MAO-A) levels elevate in PCa, and antidepressant MAO-Is show anti-PCa properties. In this work, we aimed to find potential drugs for… read more here.
Keywords: prostate cancer; mao; pca; anti pca ... See more keywords
Antiproliferative Effects of Hop-derived Prenylflavonoids and Their Influence on the Efficacy of Oxaliplatine, 5-fluorouracil and Irinotecan in Human ColorectalC Cells
Sign Up to like & getrecommendations! Published in 2019 at "Nutrients"
DOI: 10.3390/nu11040879
Abstract: Beer, the most popular beverage containing hops, is also frequently consumed by cancer patients. Moreover, non-alcoholic beer, owing to its nutritional value and high content of biological active compounds, is sometimes recommended to patients by… read more here.
Keywords: hop derived; derived prenylflavonoids; effects hop; efficacy ... See more keywords
Hydroxycamptothecin mediates antiproliferative effects through apoptosis and autophagy in A549 cells
Sign Up to like & getrecommendations! Published in 2018 at "Oncology Letters"
DOI: 10.3892/ol.2018.8107
Abstract: Hydroxycamptothecin (HCPT) represents a new generation of anticancer drugs, with almost no side effects when used for the treatment of a number of types of cancer. Autophagy is becoming recognized as an important biological mechanism… read more here.
Keywords: a549 cells; apoptosis autophagy; lung cancer; cancer ... See more keywords