Design, synthesis, in silico and antiproliferative evaluation of novel pyrazole derivatives as VEGFR‐2 inhibitors
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DOI: 10.1002/ardp.201700234
Abstract: As the blockade of the VEGFR‐2 signaling pathway is a viable approach in cancer therapy, the present study focuses on a series of pyrazole based VEGFR‐2 inhibitors that were designed on the basis of the… read more here.
Keywords: design synthesis; evaluation novel; synthesis silico; vegfr inhibitors ... See more keywords
Synthesis and antiproliferative evaluation of some iron chelators as polyamine transporter targeting agents
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DOI: 10.1139/cjc-2019-0036
Abstract: A series of kojic acid derivatives based on monoamines, diamines, and triamines have been synthesized in good yield and purity. A spermidine (spd) rescue experiment was applied against MCF-7 cells to evaluate the polyamine transporter… read more here.
Keywords: antiproliferative evaluation; transporter; polyamine transporter; synthesis antiproliferative ... See more keywords
In Vitro Antiproliferative Evaluation of Synthetic Meroterpenes Inspired by Marine Natural Products
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DOI: 10.3390/md17120684
Abstract: Several marine natural linear prenylquinones/hydroquinones have been identified as anticancer and antimutagenic agents. Structure-activity relationship studies on natural compounds and their synthetic analogs demonstrated that these effects depend on the length of the prenyl side… read more here.
Keywords: synthetic meroterpenes; marine natural; vitro antiproliferative; inspired marine ... See more keywords