Development of Isatin‐Based Schiff Bases Targeting VEGFR‐2 Inhibition: Synthesis, Characterization, Antiproliferative Properties, and QSAR Studies
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200164
Abstract: Three sets of isatin‐based Schiff bases were synthesized utilizing the molecular hybridization approach. Some of the synthesized Schiff bases show significant to moderate antiproliferative properties against MCF7 (breast), HCT116 (colon), and PaCa2 (pancreatic) cancer cell… read more here.
Keywords: schiff bases; qsar studies; vegfr inhibition; based schiff ... See more keywords
Target identification of a novel unsymmetrical 1,3,4‐oxadiazole derivative with antiproliferative properties
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30120
Abstract: 1,3,4‐Oxadiazole derivatives are widely used in research on antineoplastic drugs. Recently, we discovered a novel unsymmetrical 1,3,4‐oxadiazole compound with antiproliferative properties called 2j. To further investigate its possible targets and molecular mechanisms, RNA‐seq was performed… read more here.
Keywords: unsymmetrical oxadiazole; target identification; novel unsymmetrical; antiproliferative properties ... See more keywords
The "Janus face" of the thrombin binding aptamer: Investigating the anticoagulant and antiproliferative properties through straightforward chemical modifications.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2017.11.005
Abstract: BACKGROUND The thrombin binding aptamer (TBA) is endowed with both anticoagulant and antiproliferative activities. Its chemico-physical and/or biological properties can be tuned by the site-specific replacement of selected residues. METHODS Four oligodeoxynucleotides (ODNs) based on… read more here.
Keywords: binding aptamer; anticoagulant antiproliferative; antiproliferative properties; residues positions ... See more keywords
Synthesis and Antiproliferative Properties of Bifunctional Allocolchicine Derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Synthesis"
DOI: 10.1055/s-0037-1610146
Abstract: Based on the natural antimitotic agent colchifoline as a lead structure, a series of novel bifunctional allocolchicine congeners were synthesized from commercial colchicine. The new derivatives maintain good cytotoxicity against T3M4, MiaPaCa-2, and PANC-1 cell… read more here.
Keywords: properties bifunctional; bifunctional allocolchicine; antiproliferative properties; synthesis antiproliferative ... See more keywords
Tumorigenic and Antiproliferative Properties of the TALE-Transcription Factors MEIS2D and MEIS2A in Neuroblastoma.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-1860
Abstract: Neuroblastoma is one of only a few human cancers that can spontaneously regress even after extensive dissemination, a poorly understood phenomenon that occurs in as many as 10% of patients. In this study, we identify… read more here.
Keywords: transcription; tale transcription; properties tale; neuroblastoma ... See more keywords
Two New Adenosine Derivatives and their Antiproliferative Properties, an In Vitro Evaluation.
Sign Up to like & getrecommendations! Published in 2021 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520621666210528151818
Abstract: BACKGROUND Adenosine is a natural nucleoside present in various organs and tissues, where it acts as a modulator of diverse physiological and pathophysiological processes. These actions are mediated by at least four G protein-coupled receptors,… read more here.
Keywords: cell lines; two new; antiproliferative properties; cancer ... See more keywords
Antiproliferative Properties of Scandium Exopolysaccharide Complexes on Several Cancer Cell Lines
Sign Up to like & getrecommendations! Published in 2021 at "Marine Drugs"
DOI: 10.3390/md19030174
Abstract: Antimetastatic properties on both murine and human osteosarcoma cell lines (POS-1 and KHOS) have been evidenced using exopolysaccharide (EPS) derivatives, produced by Alteromonas infernus bacterium. These derivatives had no significant effect on the cell cycle… read more here.
Keywords: cell lines; effect; antiproliferative properties; cancer cell ... See more keywords
Highly Aromatic Flavan-3-ol Derivatives from Palaeotropical Artocarpus lacucha Buch.-Ham Possess Radical Scavenging and Antiproliferative Properties
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26041078
Abstract: Phytochemical investigation of leaves and stembark of Artocarpus lacucha collected in Thailand resulted in three yet undescribed isomeric flavan-3-ol derivatives (1–3), the four known compounds gambircatechol (4), (+)-catechin (5), (+)-afzelechin (6) and the stilbene oxyresveratrol… read more here.
Keywords: artocarpus lacucha; antiproliferative properties; radical scavenging; flavan derivatives ... See more keywords
Antiproliferative Properties of Triterpenoids by ECIS Method—A New Promising Approach in Anticancer Studies?
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27103150
Abstract: Electric cell–substrate impedance sensing is an advanced in vitro impedance measuring system which uses alternating current to determine behavior of cells in physiological conditions. In this study, we used the abovementioned method for checking the… read more here.
Keywords: triterpenoids ecis; ecis method; properties triterpenoids; anticancer ... See more keywords
Synthesis, Characterization, and Antiproliferative Properties of New Bio-Inspired Xanthylium Derivatives
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28031102
Abstract: Xanthylium derivatives are curcumin analogs showing photochromic properties. Similarly, to anthocyanins, they follow the same multistate network of chemical species that are reversibly interconverted by external stimuli. In the present work, two new asymmetric monocarbonyl… read more here.
Keywords: properties new; xanthylium derivatives; new bio; characterization antiproliferative ... See more keywords