Antiprotozoal agents: How have they changed over a decade?
Sign Up to like & getrecommendations! Published in 2021 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202100338
Abstract: Neglected tropical diseases are a diverse group of communicable diseases that are endemic in low- or low-to-middle-income countries located in tropical and subtropical zones. The number and availability of drugs for treating these diseases are… read more here.
Keywords: agents changed; decade; changed decade; antiprotozoal agents ... See more keywords
Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.06.063
Abstract: We discovered a series of azole antifungal compounds as effective antiprotozoal agents. They displayed promising inhibitory activities within the micromolar-submicromolar range against P. falciparum, L. donovani, and T. b. rhodesiense. Moreover, most of such compounds showed excellent nanomolar… read more here.
Keywords: activity relationships; antiprotozoal agents; structure activity; biological evaluation ... See more keywords
New Benzoxazole Derivatives as Antiprotozoal Agents: In Silico Studies, Synthesis, and Biological Evaluation
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DOI: 10.1155/2021/6631868
Abstract: Background. Benzoxazole derivatives have different biological activities. In pursuit of designing novel chemical entities with antiprotozoal and antimicrobial activities, benzoxazolyl aniline was utilized as a privileged scaffold of a series of (3-benzoxazole-2-yl) phenylamine derivatives, 3-benzoxazoloyl… read more here.
Keywords: antiprotozoal agents; biological evaluation; benzoxazolyl aniline; chemistry ... See more keywords
Recent Advances in the Development of Triose Phosphate Isomerase Inhibitors as Antiprotozoal Agents.
Sign Up to like & getrecommendations! Published in 2021 at "Current medicinal chemistry"
DOI: 10.2174/0929867328666210913090928
Abstract: BACKGROUND Parasitic diseases caused by protozoa such as Chagas disease, leishmaniasis, malaria, African trypanosomiasis, amebiasis, trichomoniasis, and giardiasis are considered serious public health problems in developing countries. Drug-resistance among parasites justifies the search for new… read more here.
Keywords: triose phosphate; antiprotozoal agents; inhibitors antiprotozoal; tim ... See more keywords
Mining Sudanese Medicinal Plants for Antiprotozoal Agents
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.00865
Abstract: Neglected tropical diseases are major health hazards in developing countries. Annually, up to 30 million people are affected by either Chagas disease, African trypansomiasis or leishmaniasis, and more than 200 million by malaria. Most of… read more here.
Keywords: antiprotozoal agents; mining sudanese; plants antiprotozoal; medicinal plants ... See more keywords
Recent Advances in the Discovery of Novel Antiprotozoal Agents
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24213886
Abstract: Parasitic diseases have serious health, social, and economic impacts, especially in the tropical regions of the world. Diseases caused by protozoan parasites are responsible for considerable mortality and morbidity, affecting more than 500 million people… read more here.
Keywords: antiprotozoal agents; advances discovery; discovery novel; recent advances ... See more keywords