Association of Antipsychotic Drug Exposure in Pregnancy With Risk of Neurodevelopmental Disorders: A National Birth Cohort Study.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2022.0375
Abstract: Importance Although antipsychotic drugs cross the placenta and animal data suggest potential neurotoxic effects, information regarding human neurodevelopmental teratogenicity is limited. Objective To evaluate whether children prenatally exposed to antipsychotic medication are at an increased… read more here.
Keywords: antipsychotic drug; risk; cohort; cohort study ... See more keywords
Rates of Antipsychotic Drug Prescribing Among People Living With Dementia During the COVID-19 Pandemic.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2022.4448
Abstract: Importance Concerns have been raised that the use of antipsychotic medication for people living with dementia might have increased during the COVID-19 pandemic. Objective To examine multinational trends in antipsychotic drug prescribing for people living… read more here.
Keywords: drug prescribing; antipsychotic drug; living dementia; people living ... See more keywords
Combined in silico and in vitro approaches identified the antipsychotic drug lurasidone and the antiviral drug elbasvir as SARS-CoV2 and HCoV-OC43 inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2021.105055
Abstract: The current emergency of the novel coronavirus SARS-CoV2 urged the need for broad-spectrum antiviral drugs as the first line of treatment. Coronaviruses are a large family of viruses that already challenged humanity in at least… read more here.
Keywords: hcov oc43; antipsychotic drug; sars cov2; drug ... See more keywords
Spontaneous recovery after controlled cortical impact injury is not impeded by intermittent administration of the antipsychotic drug risperidone
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.06.007
Abstract: Several preclinical studies have reported that daily administration of the antipsychotic drug (APD) risperidone (RISP) impedes recovery after traumatic brain injury (TBI). However, it is not known whether intermittent dosing would produce similar deleterious effects.… read more here.
Keywords: recovery; administration; antipsychotic drug; administration antipsychotic ... See more keywords
One-step sonochemical synthesis of 1D β-stannous tungstate nanorods: An efficient and excellent electrocatalyst for the selective electrochemical detection of antipsychotic drug chlorpromazine.
Sign Up to like & getrecommendations! Published in 2018 at "Ultrasonics sonochemistry"
DOI: 10.1016/j.ultsonch.2018.02.025
Abstract: In the modern world, the contamination of ecosystem by human and veterinary pharmaceutical drugs through the metabolic excretion, improper disposal/industrial waste has been subjected to a hot issue. Therefore, exploitation of exclusive structured material and… read more here.
Keywords: detection; stannous tungstate; antipsychotic drug; drug ... See more keywords
STRUCTURE OF THE D2 DOPAMINE RECEPTOR BOUND TO THE ATYPICAL ANTIPSYCHOTIC DRUG RISPERIDONE
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/nature25758
Abstract: Dopamine is a neurotransmitter that has been implicated in processes as diverse as reward, addiction, control of coordinated movement, metabolism and hormonal secretion. Correspondingly, dysregulation of the dopaminergic system has been implicated in diseases such… read more here.
Keywords: atypical antipsychotic; antipsychotic drug; structure; drd2 ... See more keywords
The Differential Binding of Antipsychotic Drugs to the ABC Transporter P-Glycoprotein Predicts Cannabinoid–Antipsychotic Drug Interactions
Sign Up to like & getrecommendations! Published in 2017 at "Neuropsychopharmacology"
DOI: 10.1038/npp.2017.50
Abstract: Cannabis use increases rates of psychotic relapse and treatment failure in schizophrenia patients. Clinical studies suggest that cannabis use reduces the efficacy of antipsychotic drugs, but there has been no direct demonstration of this in… read more here.
Keywords: abc transporter; antipsychotic drug; transporter glycoprotein; risperidone ... See more keywords
Dopamine D2 receptors and the circadian clock reciprocally mediate antipsychotic drug-induced metabolic disturbances
Sign Up to like & getrecommendations! Published in 2017 at "NPJ Schizophrenia"
DOI: 10.1038/s41537-017-0018-4
Abstract: Antipsychotic drugs are widely prescribed medications, used for numerous psychiatric illnesses. However, antipsychotic drugs cause serious metabolic side effects that can lead to substantial weight gain and increased risk for type 2 diabetes. While individual… read more here.
Keywords: antipsychotic drug; dopamine receptors; drug induced; dopamine ... See more keywords
Metabolism of the antipsychotic drug olanzapine by CYP3A43
Sign Up to like & getrecommendations! Published in 2022 at "Xenobiotica"
DOI: 10.1080/00498254.2022.2078751
Abstract: Abstract 1. Olanzapine is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder. An intronic single nucleotide polymorphism (SNP) that highly significantly predicts increased olanzapine clearance (rs472660) was previously identified in the CYP3A43… read more here.
Keywords: metabolism; olanzapine cyp3a43; antipsychotic drug; cyp3a43 ... See more keywords
Identification of antipsychotic drug fluspirilene as a potential anti-glioma stem cell drug
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.22904
Abstract: Glioma stem cell (GSC)-targeted therapy is expected to be one of the most innovative approaches to treat patients with glioblastoma (GBM). A number of the drugs that restrain the signaling pathway essential for GSC maintenance… read more here.
Keywords: glioma stem; glioma; antipsychotic drug; drug ... See more keywords
Influence of Antipsychotic Drug Risperidone on Human Serum Albumin Affinity to Organic Anions.
Sign Up to like & getrecommendations! Published in 2018 at "Current drug discovery technologies"
DOI: 10.2174/1570163814666171106153639
Abstract: BACKGROUND Risperidone is an antipsychotic drug. In blood, this drug binds mainly to human serum albumin (HSA) and is also transported by HSA. METHOD To study certain details of the interaction between risperidone and HSA,… read more here.
Keywords: antipsychotic drug; drug; human serum; capidan ... See more keywords