Rhodiola rosea root extract has antipsychotic-like effects in rodent models of sensorimotor gating.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2019.02.031
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE: The plant arctic root (Rhodiola rosea, L.) is growing in northern regions of Europe, Asia and North America. Extracts of R. rosea are used in traditional medicine for various conditions related to nervous system… read more here.
Keywords: rosea root; inhibition; antipsychotic like; prepulse inhibition ... See more keywords
Activation of the mGlu1 metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M4 muscarinic receptor allosteric modulators
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Psychiatry"
DOI: 10.1038/s41380-018-0206-2
Abstract: Recent clinical and preclinical studies suggest that selective activators of the M4 muscarinic acetylcholine receptor have potential as a novel treatment for schizophrenia. M4 activation inhibits striatal dopamine release by mobilizing endocannabinoids, providing a mechanism… read more here.
Keywords: metabotropic glutamate; antipsychotic like; like effects; activation ... See more keywords
Antipsychotic- and Anxiolytic-like Properties of a Multimodal Compound JJGW08 in Rodents
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415929
Abstract: Schizophrenia is a chronic mental illness, which remains difficult to treat. A high resistance to the available therapies, their insufficient efficacy, and numerous side effects are the reasons why there is an urgent need to… read more here.
Keywords: ht2a ht7; compound; jjgw08; like properties ... See more keywords