M102 VARIATION IN VOLTAGE-GATED CALCIUM CHANNEL GENES IS ASSOCIATED WITH ANTIPSYCHOTIC TREATMENT RESPONSE IN A SOUTH AFRICAN FIRST EPISODE SCHIZOPHRENIA COHORT
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.409
Abstract: Background Voltage-gated calcium channels have been implicated in schizophrenia aetiology, however little is known about their involvement in antipsychotic treatment response. This study investigated variants within the calcium channel subunit genes for association with antipsychotic… read more here.
Keywords: treatment response; calcium channel; treatment; south african ... See more keywords
Effects of chronic antipsychotic treatment on neurophysiological correlates of the auditory oddball task in schizophrenia: A preliminary report from a multicentre study
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DOI: 10.1016/j.eurpsy.2017.01.2124
Abstract: Introduction The effects of chronic antipsychotic administration on the human brain are debated. In particular, first-generation (FGAs) and second-generation antipsychotics (SGAs) seem to have different impacts on brain function and structure in subjects with schizophrenia.… read more here.
Keywords: effects chronic; oddball task; p300 latency; chronic antipsychotic ... See more keywords
Adiponectin, leptin and resistin levels in first-episode, drug-naïve patients with psychosis before and after short-term antipsychotic treatment.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of psychosomatic research"
DOI: 10.1016/j.jpsychores.2022.110789
Abstract: OBJECTIVE There is increasing evidence that adiponectin, resistin and leptin may be implicated in the pathophysiology of neuropsychiatric disorders, including schizophrenia. The results of the studies so far remain controversial. Our aim was to compare… read more here.
Keywords: adiponectin; antipsychotic treatment; resistin; resistin levels ... See more keywords
Neurotensin in the nucleus accumbens reverses dopamine supersensitivity evoked by antipsychotic treatment
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DOI: 10.1016/j.neuropharm.2017.05.015
Abstract: &NA; Long‐term exposure to antipsychotics like haloperidol can increase sensitivity to dopamine agonist stimulation. This could contribute to treatment failure and increase relapse to psychosis. Chronic antipsychotic treatment elevates neurotensin levels in the nucleus accumbens… read more here.
Keywords: dopamine supersensitivity; treatment; neurotensin; hal ... See more keywords
DNA methylation and antipsychotic treatment mechanisms in schizophrenia: Progress and future directions
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DOI: 10.1016/j.pnpbp.2017.10.004
Abstract: &NA; Antipsychotic response in schizophrenia is a complex, multifactorial trait influenced by pharmacogenetic factors. With genetic studies thus far providing little biological insight or clinical utility, the field of pharmacoepigenomics has emerged to tackle the… read more here.
Keywords: methylation; dna methylation; response; antipsychotic treatment ... See more keywords
Increase in serum HDL level is associated with less negative symptoms after one year of antipsychotic treatment in first-episode psychosis
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DOI: 10.1016/j.schres.2017.10.042
Abstract: BACKGROUND A potential link between increase in total cholesterol and triglycerides and clinical improvement has been observed during antipsychotic drug treatment in chronic schizophrenia patients, possibly due to drug related effects on lipid biosynthesis. We… read more here.
Keywords: treatment; one year; increase; psychosis ... See more keywords
Disrupted sensorimotor gating in first-episode psychosis patients is not affected by short-term antipsychotic treatment
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DOI: 10.1016/j.schres.2020.12.009
Abstract: BACKGROUND Impaired sensorimotor gating, commonly measured as disrupted prepulse inhibition (PPI) of the acoustic startle response, has been widely observed in psychotic diseases. However, most PPI studies published so far involve patients with long illness… read more here.
Keywords: sensorimotor gating; treatment; first episode; episode psychosis ... See more keywords
Use of antipsychotics in Denmark 1997–2018: a nation-wide drug utilisation study with focus on off-label use and associated diagnoses
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DOI: 10.1017/s2045796021000159
Abstract: Abstract Aims Antipsychotics are primarily labelled for the treatment of severe mental illness and have documented clinical utility in certain neurological disorders or palliative care. However, off-label use of antipsychotics is common and increasing, and… read more here.
Keywords: antipsychotic treatment; treatment; relevant antipsychotic; without diagnoses ... See more keywords
Antipsychotic Treatment Duration in Children and Adolescents: A Register-Based Nationwide Study.
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DOI: 10.1089/cap.2020.0095
Abstract: Objective: Despite the increasing use of antipsychotic drugs in children and adolescents in many countries, little is known about the treatment duration in this vulnerable population. The present nationwide study investigated the duration of antipsychotic… read more here.
Keywords: treatment; duration; nationwide study; children adolescents ... See more keywords
Primary Nonadherence to Antipsychotic Treatment Among Persons with Schizophrenia
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DOI: 10.1093/schbul/sbac014
Abstract: Abstract It has remained unclear what factors relate to primary nonadherence to antipsychotic treatment and whether specific agents and routes of administration differ in how patients adhere to them. We collected electronic prescriptions and their… read more here.
Keywords: primary nonadherence; treatment among; antipsychotic treatment; nonadherence ... See more keywords
Longitudinal Network Analysis Reveals Interactive Change of Schizophrenia Symptoms During Acute Antipsychotic Treatment.
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DOI: 10.1093/schbul/sbac131
Abstract: BACKGROUND AND HYPOTHESIS Complex schizophrenia symptoms were recently conceptualized as interactive symptoms within a network system. However, it remains unknown how a schizophrenia network changed during acute antipsychotic treatment. The present study aimed to evaluate… read more here.
Keywords: acute antipsychotic; network; schizophrenia symptoms; antipsychotic treatment ... See more keywords