Antiretroviral drug exposure in lymph nodes is heterogeneous and drug dependent
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the International AIDS Society"
DOI: 10.1002/jia2.25895
Abstract: HIV reservoirs and infected cells may persist in tissues with low concentrations of antiretrovirals (ARVs). Traditional pharmacology methods cannot assess variability in ARV concentrations within morphologically complex tissues, such as lymph nodes (LNs). We evaluated… read more here.
Keywords: drug exposure; nodes heterogeneous; drug; exposure lymph ... See more keywords
Antiretroviral drug switches to zidovudine‐based regimens and loss to follow‐up during the first COVID‐19 lockdown in Bali, Indonesia
Sign Up to like & getrecommendations! Published in 2022 at "HIV Medicine"
DOI: 10.1111/hiv.13298
Abstract: International lockdowns during the COVID‐19 pandemic impacted antiretroviral drug supplies in Indonesia. We assessed the impact of antiretroviral treatment (ART) provision and being lost to follow‐up (LTFU) on people living with HIV, attending a key… read more here.
Keywords: bali; zidovudine based; drug switches; antiretroviral drug ... See more keywords
Evolution of Antiretroviral Drug Rilpivirine and Approach to Oncology
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DOI: 10.3390/ijms24032890
Abstract: Rilpivirine is an antiretroviral drug used to treat AIDS worldwide. The drug is a non-nucleoside reverse transcriptase inhibitor that halts the cDNA elongation process and, thus, the capacity of the HIV-1 virus to replicate. With… read more here.
Keywords: rilpivirine; oncology; evolution antiretroviral; antiretroviral drug ... See more keywords
Comprehensive Study of Antiretroviral Drug Permeability at the Cervicovaginal Mucosa via an In Vitro Model
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DOI: 10.3390/pharmaceutics14091938
Abstract: Modulation of drug transporter activity at mucosal sites of HIV-1 transmission may be exploited to optimize retention of therapeutic antiretroviral drug concentrations at target submucosal CD4+ T cells. Previously, we showed that darunavir was a… read more here.
Keywords: transporter; drug permeability; model; antiretroviral drug ... See more keywords