Antiseizure medication discovery: Recent and future paradigm shifts.
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia open"
DOI: 10.1002/epi4.12581
Abstract: Despite the ever-increasing number of available options for the treatment of epilepsies and the remarkable advances on the understanding of their pathophysiology, the proportion of refractory patients has remained approximately unmodified during the last 100… read more here.
Keywords: antiseizure; discovery recent; antiseizure medication; future paradigm ... See more keywords
Clemizole and trazodone are effective antiseizure treatments in a zebrafish model of STXBP1 disorder
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DOI: 10.1002/epi4.12604
Abstract: Objective CRISPR-Cas9-generated zebrafish carrying a 12 base-pair deletion in stxbpb1b, a paralog sharing 79% amino acid sequence identity with human, exhibit spontaneous electrographic seizures during larval stages of development. Zebrafish stxbp1b mutants provide an efficient… read more here.
Keywords: antiseizure; clemizole trazodone; zebrafish model; effective antiseizure ... See more keywords
Discovery of (R)-N-Benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide [(R)-AS-1], a Novel Orally Bioavailable EAAT2 Modulator with Drug-like Properties and Potent Antiseizure Activity In Vivo
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00534
Abstract: (R)-7 [(R)-AS-1] showed broad-spectrum antiseizure activity across in vivo mouse seizure models: maximal electroshock (MES), 6 Hz (32/44 mA), acute pentylenetetrazol (PTZ), and PTZ-kindling. A remarkable separation between antiseizure activity and CNS-related adverse effects was… read more here.
Keywords: antiseizure; drug like; vivo; antiseizure activity ... See more keywords
Zebrafish-Based Screening of Antiseizure Plants Used in Traditional Chinese Medicine: Magnolia officinalis Extract and Its Constituents Magnolol and Honokiol Exhibit Potent Anticonvulsant Activity in a Therapy-Resistant Epilepsy Model.
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DOI: 10.1021/acschemneuro.9b00610
Abstract: With the aim to discover interesting lead compounds that could be further developed into compounds active against pharmacoresistant epilepsies, we first collected 14 medicinal plants used in traditional Chinese medicine (TCM) against epilepsy. Of the… read more here.
Keywords: epilepsy; medicine; antiseizure; therapy resistant ... See more keywords
Testing association of rare genetic variants with resistance to three common antiseizure medications
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DOI: 10.1111/epi.16467
Abstract: Drug resistance is a major concern in the treatment of individuals with epilepsy. No genetic markers for resistance to individual antiseizure medication (ASM) have yet been identified. We aimed to identify the role of rare… read more here.
Keywords: antiseizure; resistance three; genetic variants; resistance ... See more keywords
A pharmacokinetic model of antiseizure medication load to guide care in the epilepsy monitoring unit
Sign Up to like & getrecommendations! Published in 2023 at "Epilepsia"
DOI: 10.1111/epi.17558
Abstract: Evaluating patients with drug‐resistant epilepsy often requires inducing seizures by tapering antiseizure medications (ASMs) in the epilepsy monitoring unit (EMU). The relationship between ASM taper strategy, seizure timing, and severity remains unclear. In this study,… read more here.
Keywords: epilepsy monitoring; monitoring unit; antiseizure; pharmacokinetic model ... See more keywords
Should substitution monotherapy or combination therapy be used after failure of the first antiseizure medication? Observations from a 30‐year cohort study
Sign Up to like & getrecommendations! Published in 2023 at "Epilepsia"
DOI: 10.1111/epi.17573
Abstract: To assess the temporal trends in the use of second antiseizure (ASM) regimens and compare the efficacy of substitution monotherapy and combination therapy after failure of initial monotherapy in people with epilepsy. read more here.
Keywords: monotherapy combination; antiseizure; monotherapy; substitution monotherapy ... See more keywords
Association Between Frailty and Antiseizure Medication Tolerability in Older Adults With Epilepsy
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DOI: 10.1212/wnl.0000000000201701
Abstract: Background and Objective Frailty is an important aspect of biological aging, referring to the increased vulnerability of individuals with frailty to physical and psychological stressors. While older adults with epilepsy are an important and distinct… read more here.
Keywords: antiseizure; older adults; adults epilepsy; tolerability ... See more keywords
Author Response: Effectiveness of Antiseizure Medication Duotherapies in Patients With Glioma: A Multicenter Observational Cohort Study
Sign Up to like & getrecommendations! Published in 2023 at "Neurology"
DOI: 10.1212/wnl.0000000000201719
Abstract: We appreciate the comments from Zhao et al. on our article.1 We agree that it is important to classify patients according to the latest World Health Organization (WHO) classification criteria for CNS tumors to best… read more here.
Keywords: antiseizure; response effectiveness; cohort; author response ... See more keywords
Is It Time to Test the Antiseizure Potential of Palmitoylethanolamide in Human Studies? A Systematic Review of Preclinical Evidence
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DOI: 10.3390/brainsci12010101
Abstract: Antiseizure medications are the cornerstone pharmacotherapy for epilepsy. They are not devoid of side effects. In search for better-tolerated antiseizure agents, cannabinoid compounds and other N-acylethanolamines not directly binding cannabinoid receptors have drawn significant attention.… read more here.
Keywords: antiseizure; antiseizure potential; time test; potential palmitoylethanolamide ... See more keywords
Antiseizure Effects of Scoparone, Borneol and Their Impact on the Anticonvulsant Potency of Four Classic Antiseizure Medications in the Mouse MES Model—An Isobolographic Transformation
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021395
Abstract: Numerous botanical drugs containing coumarins and terpenes are used in ethnomedicine all over the world for their various therapeutic properties, especially those affecting the CNS system. The treatment of epilepsy is based on antiseizure medications… read more here.
Keywords: antiseizure; mes model; drug; scoparone borneol ... See more keywords