Prenatal Exposure to Antiseizure Medication and Incidence of Childhood- and Adolescence-Onset Psychiatric Disorders.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2023.0674
Abstract: Importance Prenatal antiseizure medication (ASM) exposure has been associated with adverse early neurodevelopment, but associations with a wider range of psychiatric end points have not been studied. Objective To examine the association between prenatal exposure… read more here.
Keywords: psychiatric disorders; antiseizure medication; childhood adolescence; prenatal exposure ... See more keywords
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations
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DOI: 10.1002/ana.26561
Abstract: This study was undertaken to examine the comparative safety of antiseizure medication (ASM) monotherapy in pregnancy with respect to risk of major congenital malformations (MCMs), overall and by MCM subtype. read more here.
Keywords: antiseizure medication; safety antiseizure; comparative safety;
Antiseizure medication discovery: Recent and future paradigm shifts.
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia open"
DOI: 10.1002/epi4.12581
Abstract: Despite the ever-increasing number of available options for the treatment of epilepsies and the remarkable advances on the understanding of their pathophysiology, the proportion of refractory patients has remained approximately unmodified during the last 100… read more here.
Keywords: antiseizure; discovery recent; antiseizure medication; future paradigm ... See more keywords
Frequency of and factors associated with antiseizure medication discontinuation discussions and decisions in patients with epilepsy: A multicenter retrospective chart review
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DOI: 10.1002/epi4.12695
Abstract: Guidelines suggest considering antiseizure medication (ASM) discontinuation in patients with epilepsy who become seizure‐free. Little is known about how discontinuation decisions are being made in practice. We measured the frequency of, and factors associated with,… read more here.
Keywords: patients epilepsy; antiseizure medication; discussions decisions; frequency factors ... See more keywords
Antiseizure medication withdrawal risk estimation and recommendations: A survey of American Academy of Neurology and EpiCARE members
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DOI: 10.1002/epi4.12696
Abstract: Choosing candidates for antiseizure medication (ASM) withdrawal in well‐controlled epilepsy is challenging. We evaluated (a) the correlation between neurologists' seizure risk estimation (“clinician predictions”) vs calculated predictions, (b) how viewing calculated predictions influenced recommendations, and… read more here.
Keywords: neurology; antiseizure medication; withdrawal; risk estimation ... See more keywords
Brain function and network features in patients with chronic epilepsy before and after antiseizure medication withdrawal
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DOI: 10.1016/j.eplepsyres.2021.106740
Abstract: OBJECTIVES A considerable proportion of epilepsy patients who achieved long-term seizure freedom with standardized treatment of antiseizure medication will attempt to withdraw medications. Epilepsy is currently considered as a network disease, however, the characteristics of… read more here.
Keywords: network; medication withdrawal; antiseizure medication; medication ... See more keywords
KCNQ2 -Related Epilepsy: Genotype–Phenotype Relationship with Tailored Antiseizure Medication (ASM)—A Systematic Review
Sign Up to like & getrecommendations! Published in 2022 at "Neuropediatrics"
DOI: 10.1055/a-2060-4576
Abstract: Abstract Autosomal dominant mutations of the KCNQ2 gene can cause two epileptic disorders: benign familial neonatal seizures (BFNS) and developmental epileptic encephalopathy (DEE). This systematic review aims to identify the best reported therapy for these… read more here.
Keywords: phenotype; antiseizure medication; genotype; systematic review ... See more keywords
Antiseizure medication-induced obsessive-compulsive disorder and tic disorder: a pragmatic review
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Neurotherapeutics"
DOI: 10.1080/14737175.2022.2117614
Abstract: ABSTRACT Introduction With a lifetime prevalence of 2.3%, obsessive compulsive disorder is a chronic, disabling condition that is associated with significant social and occupational impairment. Up to 30% of individuals with obsessive-compulsive disorder have a… read more here.
Keywords: antiseizure medication; compulsive disorder; disorder; induced obsessive ... See more keywords
Antiseizure medication treatment pathways for US Medicare beneficiaries with newly treated epilepsy
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DOI: 10.1111/epi.17226
Abstract: This study was undertaken to characterize antiseizure medication (ASM) treatment pathways in Medicare beneficiaries with newly treated epilepsy. read more here.
Keywords: pathways medicare; antiseizure medication; treatment pathways; newly treated ... See more keywords
Gene panel to guide antiseizure medication prescribing: Does the cost justify the benefits?
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia"
DOI: 10.1111/epi.17418
Abstract: Pharmacogenomics hold the potential to identify variants associated with adverse drug reactions and treatment efficacy of anti‐seizure medications. A model‐based cost‐utility analysis by Gordon and colleagues showed that genetically‐guided therapy costs more, yielded higher quality‐adjusted… read more here.
Keywords: guide antiseizure; antiseizure medication; cost; gene panel ... See more keywords
Prognostic interictal electroencephalographic biomarkers and models to assess antiseizure medication efficacy for clinical practice: A scoping review
Sign Up to like & getrecommendations! Published in 2023 at "Epilepsia"
DOI: 10.1111/epi.17548
Abstract: Antiseizure medication (ASM) is the primary treatment for epilepsy. In clinical practice, methods to assess ASM efficacy (predict seizure freedom or seizure reduction), during any phase of the drug treatment lifecycle, are limited. This scoping… read more here.
Keywords: antiseizure medication; review; efficacy; clinical practice ... See more keywords