Long noncoding antisense RNA FAM83A‐AS1 promotes lung cancer cell progression by increasing FAM83A
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28336
Abstract: The abnormal expression of long noncoding RNAs (lncRNAs) is closely associated with human cancers. As one special group of lncRNAs, natural antisense transcripts (NATs) can be transcribed from both DNA strands at the same locus… read more here.
Keywords: antisense; fam83a as1; fam83a; cancer ... See more keywords
Delivery of Antisense Oligonucleotides Mediated by a Hydrogel System: In Vitro and In Vivo Application in the Context of Spinal Cord Injury.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9670-4_12
Abstract: Biomaterials-based hydrogels are attractive drug-eluting vehicles in the context of RNA therapeutics, such as those utilizing antisense oligonucleotide or RNA interference based drugs, as they can potentially reduce systemic toxicity and enhance in vivo efficacy… read more here.
Keywords: antisense; system; cord injury; spinal cord ... See more keywords
Identification of a novel antisense long non-coding RNA PLA2G16-AS that regulates the expression of PLA2G16 in pigs.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.05.114
Abstract: Natural antisense transcripts (NATs) are widely present in mammalian genomes and act as pivotal regulator molecules to control gene expression. However, studies on the NATs of pigs are relatively rare. Here, we identified a novel… read more here.
Keywords: pla2g16; antisense; rna; identification novel ... See more keywords
R-Loops Promote Antisense Transcription across the Mammalian Genome
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cell"
DOI: 10.1016/j.molcel.2019.10.002
Abstract: Summary Widespread antisense long noncoding RNA (lncRNA) overlap with many protein-coding genes in mammals and emanate from gene promoter, enhancer, and termination regions. However, their origin and biological purpose remain unclear. We show that these… read more here.
Keywords: antisense; antisense transcription; promote antisense; genome ... See more keywords
Helix-Stabilized Cell-Penetrating Peptides for Delivery of Antisense Morpholino Oligomers: Relationships among Helicity, Cellular Uptake, and Antisense Activity.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00199
Abstract: The secondary structures of cell-penetrating peptides (CPPs) influence their properties including their cell-membrane permeability, tolerability to proteases, and intracellular distribution. Herein, we developed helix-stabilized arginine-rich peptides containing α,α-disubstituted α-amino acids and their conjugates with antisense… read more here.
Keywords: relationships among; helix stabilized; cell penetrating; penetrating peptides ... See more keywords
Engineering Antisense Oligonucleotides as Antibacterial Agents That Target FMN Riboswitches and Inhibit the Growth of Staphylococcus aureus, Listeria monocytogenes, and Escherichia coli.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.2c00013
Abstract: In the past several decades, antibiotic drug resistance has emerged as a significant challenge in modern medicine due to the rise of many bacterial pathogenic strains resistant to all known antibiotics. At the same time,… read more here.
Keywords: antibacterial agents; antisense oligonucleotides; fmn riboswitches; agents target ... See more keywords
Antisense oligonucleotides as a potential treatment for brain deficits observed in myotonic dystrophy type 1.
Sign Up to like & getrecommendations! Published in 2022 at "Gene therapy"
DOI: 10.1038/s41434-022-00316-7
Abstract: Myotonic dystrophy, or dystrophia myotonica type 1 (DM1), is a multi-systemic disorder and is the most common adult form of muscular dystrophy. It affects not only muscles but also many organs, including the brain. Cerebral… read more here.
Keywords: antisense; brain; myotonic dystrophy; brain deficits ... See more keywords
Effective photo-enhancement of cellular activity of fluorophore-octaarginine antisense PNA conjugates correlates with singlet oxygen formation, endosomal escape and chromophore lipophilicity
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-18947-x
Abstract: Photochemical internalization (PCI) is a cellular drug delivery method based on the generation of light-induced reactive oxygen species (ROS) causing damage to the endosomal membrane and thereby resulting in drug release to the cytoplasm. In… read more here.
Keywords: oxygen; antisense; pna; singlet oxygen ... See more keywords
Upregulation of SPS100 gene expression by an antisense RNA via a switch of mRNA isoforms with different stabilities
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx737
Abstract: Abstract Pervasive transcription of genomes generates multiple classes of non-coding RNAs. One of these classes are stable long non-coding RNAs which overlap coding genes in antisense direction (asRNAs). The function of such asRNAs is not… read more here.
Keywords: antisense; gene expression; expression; mrna isoforms ... See more keywords
Klhl14 Antisense RNA is a Target of Key Skeletogenic Transcription Factors in the Developing Intervertebral Disc
Sign Up to like & getrecommendations! Published in 2019 at "SPINE"
DOI: 10.1097/brs.0000000000002827
Abstract: Study Design. RNA in situ hybridization (RISH) allows for validation and characterization of the long noncoding (lnc) natural antisense RNA (NAT) Klhl14as in the embryonic murine intervertebral disc (IVD) in the context of loss-of-function mutants… read more here.
Keywords: antisense; antisense rna; pax1 pax9; transcription factors ... See more keywords
Antisense transcription in Pseudomonas aeruginosa
Sign Up to like & getrecommendations! Published in 2018 at "Microbiology"
DOI: 10.1099/mic.0.000664
Abstract: A large number of antisense transcripts have been detected in diverse microbial genomes and considerable effort has been devoted to elucidating the functional role of antisense transcription. In this study, we reanalysed extensive RNA sequencing… read more here.
Keywords: pseudomonas aeruginosa; antisense; antisense transcription; antisense transcripts ... See more keywords