Spt5 Plays Vital Roles in the Control of Sense and Antisense Transcription Elongation.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular cell"
DOI: 10.1016/j.molcel.2017.02.023
Abstract: Spt5 is an essential and conserved factor that functions in transcription and co-transcriptional processes. However, many aspects of the requirement for Spt5 in transcription are poorly understood. We have analyzed the consequences of Spt5 depletion in… read more here.
Keywords: transcription; spt5; sense; transcription elongation ... See more keywords
R-Loops Promote Antisense Transcription across the Mammalian Genome
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cell"
DOI: 10.1016/j.molcel.2019.10.002
Abstract: Summary Widespread antisense long noncoding RNA (lncRNA) overlap with many protein-coding genes in mammals and emanate from gene promoter, enhancer, and termination regions. However, their origin and biological purpose remain unclear. We show that these… read more here.
Keywords: antisense; antisense transcription; promote antisense; genome ... See more keywords
ZWC complex-mediated SPT5 phosphorylation suppresses divergent antisense RNA transcription at active gene promoters
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac193
Abstract: Abstract The human genome encodes large numbers of non-coding RNAs, including divergent antisense transcripts at transcription start sites (TSSs). However, molecular mechanisms by which divergent antisense transcription is regulated have not been detailed. Here, we… read more here.
Keywords: zwc complex; suppresses divergent; transcription; divergent antisense ... See more keywords
Antisense transcription in Pseudomonas aeruginosa
Sign Up to like & getrecommendations! Published in 2018 at "Microbiology"
DOI: 10.1099/mic.0.000664
Abstract: A large number of antisense transcripts have been detected in diverse microbial genomes and considerable effort has been devoted to elucidating the functional role of antisense transcription. In this study, we reanalysed extensive RNA sequencing… read more here.
Keywords: pseudomonas aeruginosa; antisense; antisense transcription; antisense transcripts ... See more keywords
Sense-antisense miRNA pairs constitute an elaborate reciprocal regulatory circuit.
Sign Up to like & getrecommendations! Published in 2020 at "Genome research"
DOI: 10.1101/gr.257121.119
Abstract: Antisense transcription of protein-coding genes has been increasingly recognized as an important regulatory mechanism of gene expression. However, less is known about the extent and importance of antisense transcription of noncoding genes. Here, we investigate… read more here.
Keywords: mirna; antisense; sense; antisense transcription ... See more keywords
Antisense transcription represses Arabidopsis seed dormancy QTL DOG1 to regulate drought tolerance
Sign Up to like & getrecommendations! Published in 2017 at "EMBO reports"
DOI: 10.15252/embr.201744862
Abstract: Plants have developed multiple strategies to sense the external environment and to adapt growth accordingly. Delay of germination 1 (DOG1) is a major quantitative trait locus (QTL) for seed dormancy strength in Arabidopsis thaliana that… read more here.
Keywords: seed; antisense transcription; dog1; seed dormancy ... See more keywords
Antisense transcription‐dependent chromatin signature modulates sense transcript dynamics
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Systems Biology"
DOI: 10.15252/msb.20178007
Abstract: Antisense transcription is widespread in genomes. Despite large differences in gene size and architecture, we find that yeast and human genes share a unique, antisense transcription‐associated chromatin signature. We asked whether this signature is related… read more here.
Keywords: transcription; antisense transcription; sense transcript; chromatin signature ... See more keywords
Novel perspectives on antisense transcription in HIV-1, HTLV-1, and HTLV-2
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.1042761
Abstract: The genome of retroviruses contains two promoter elements (called long terminal repeat or LTR) at the 5′ and 3′ end of their genome. Although the expression of retroviral genes generally depends on the promoter located… read more here.
Keywords: transcription; hiv htlv; htlv htlv; htlv ... See more keywords
Cold Induced Antisense Transcription of FLOWERING LOCUS C in Distant Grasses
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2019.00072
Abstract: Functional conservation of RNAs between different species is a key argument for their importance. While few long non-coding RNAs are conserved at the sequence level, many long non-coding RNAs have been identified that only share… read more here.
Keywords: antisense transcription; cold induced; flowering locus; coolair ... See more keywords
Epigenetic Regulation of HIV-1 Sense and Antisense Transcription in Response to Latency-Reversing Agents
Sign Up to like & getrecommendations! Published in 2023 at "Non-Coding RNA"
DOI: 10.3390/ncrna9010005
Abstract: Nucleosomes positioned on the HIV-1 5′ long terminal repeat (LTR) regulate sense transcription as well as the establishment and maintenance of latency. A negative-sense promoter (NSP) in the 3′ LTR expresses antisense transcripts with coding… read more here.
Keywords: transcription; latency reversing; sense antisense; reversing agents ... See more keywords
Transcription elongation is finely tuned by dozens of regulatory factors
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.78944
Abstract: Understanding the complex network that regulates transcription elongation requires the quantitative analysis of RNA polymerase II (Pol II) activity in a wide variety of regulatory environments. We performed native elongating transcript sequencing (NET-seq) in 41… read more here.
Keywords: elongation finely; elongation; transcription; transcription elongation ... See more keywords