The impact of process parameters on carrier free paracetamol nanosuspension prepared using different stabilizers by antisolvent precipitation method
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2017.10.001
Abstract: Abstract Poor aqueous solubility leading to poor oral bioavailability is a bottle neck in the development of many new drug candidates; particularly the BCS class II-IV drugs. These molecules are difficult to formulate using conventional… read more here.
Keywords: nanosuspension prepared; drug; different stabilizers; precipitation method ... See more keywords
Equilibrium solubility and solute-solvent interactions of carvedilol (Form I) in twelve mono solvents and its application for supercritical antisolvent precipitation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2019.111622
Abstract: Abstract In recent years, various polymorphic forms have been identified, including solvates of carvedilol. In this study, the solubility values of a thermodynamically stable form (Form I) of carvedilol in acetone, 1-butanol, dichloromethane, ethanol, ethyl… read more here.
Keywords: form; antisolvent precipitation; solute solvent; solubility ... See more keywords
Liquid antisolvent precipitation: an effective method for ocular targeting of lutein esters
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s194068
Abstract: Background Lutein ester (LE) is an important carotenoid fatty acid ester. It is a form in which lutein is present in nature and is produced by free non-esterification and fatty acid esterification. LE is one… read more here.
Keywords: antisolvent precipitation; liquid antisolvent; precipitation effective; lutein ... See more keywords
Application of Antisolvent Precipitation Method for Formulating Excipient-Free Nanoparticles of Psychotropic Drugs
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14040819
Abstract: The aim of the present study was to systematically examine the effects of variations in the process parameters of the antisolvent precipitation method employed in the preparation of excipient-free pure nanoparticles of five existing/potential psychotropic… read more here.
Keywords: psychotropic drugs; precipitation method; excipient free; antisolvent precipitation ... See more keywords