Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism: a case report
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DOI: 10.1007/s11684-017-0553-4
Abstract: Antithrombin and protein C are two crucial members in the anticoagulant system and play important roles in hemostasis. Mutations in SERPINC1 and PROC lead to deficiency or dysfunction of the two proteins, which could result… read more here.
Keywords: antithrombin deficiency; protein activity; deficiency; decreased protein ... See more keywords
The Efficacy and Safety of DOACs in Inherited Antithrombin Deficiency: A Cohort Study from a Tertiary Referral Center
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DOI: 10.1055/a-2379-7288
Abstract: Abstract Background Individuals with inherited antithrombin deficiency (IATD) have a high risk of venous thromboembolism (VTE). Most VTEs are managed with direct oral anticoagulants (DOACs), but the utility of DOACs in antithrombin deficiency (ATD) is… read more here.
Keywords: doacs; inherited antithrombin; antithrombin deficiency; deficiency ... See more keywords
Diagnostic Performance of Commercial Antithrombin Activity Assays: Do We Get What We Expect?
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DOI: 10.1055/a-2628-4046
Abstract: Background Hereditary antithrombin (AT) deficiency is a rare autosomal dominant disorder that predisposes to the development of recurrent venous thromboembolism (VTE). Diagnosis is based on the measurement of reduced AT activity in plasma. However, not… read more here.
Keywords: antithrombin deficiency; type; activity assays; activity ... See more keywords
How to Manage Venous Thromboembolism Risk during Pregnancy in Patients with Inherited Antithrombin Deficiency?
Sign Up to like & getrecommendations! Published in 2025 at "Thrombosis and Haemostasis"
DOI: 10.1055/a-2650-7959
Abstract: Abstract Inherited antithrombin deficiency (ATD) is associated with a high risk of venous thromboembolic complications. Association of ATD with other conditions such as pregnancy obviously increases thromboembolic risk and may require anticoagulant therapy for prevention.… read more here.
Keywords: inherited antithrombin; risk; antithrombin deficiency; manage venous ... See more keywords
Antithrombin Deficiency Is Associated with Prothrombotic Plasma Fibrin Clot Phenotype
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DOI: 10.1055/s-0043-1768712
Abstract: BACKGROUND Deficiency of antithrombin increases risk of venous thromboembolism. We hypothesized that antithrombin deficiency affects fibrin clot structure and function. METHODS We evaluated 148 patients (age: 38 [32-50] years; 70% women) with genetically confirmed antithrombin… read more here.
Keywords: lower antithrombin; antithrombin deficiency; fibrin clot; deficiency ... See more keywords
Management of antithrombin deficiency: an update for clinicians
Sign Up to like & getrecommendations! Published in 2019 at "Expert Review of Hematology"
DOI: 10.1080/17474086.2019.1611424
Abstract: ABSTRACT Introduction. Antithrombin is a serpin that inhibits multiple procoagulant serine proteases and acts as an endogenous anticoagulant. Thus, congenital antithrombin deficiency constitutes a major thrombophilic state, the most severe so far. Areas covered. In… read more here.
Keywords: management antithrombin; deficiency update; antithrombin deficiency; update clinicians ... See more keywords
Evaluation of Acquired Antithrombin Deficiency in Pediatric Patients Supported on Extracorporeal Membrane Oxygenation.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of clinical pharmacology"
DOI: 10.1111/bcp.15703
Abstract: BACKGROUND AND PURPOSE There remains a paucity of literature regarding best practice for antithrombin (AT) monitoring, dosing, and dose-response in pediatric ECMO patients. EXPERIMENTAL APPROACH We conducted a retrospective cohort study at a quaternary care… read more here.
Keywords: deficiency pediatric; acquired antithrombin; antithrombin deficiency; activity ... See more keywords
Antithrombin Deficiency Is Associated with a Novel Homozygous Detrimental Mutation in SERPINC1 Gene in a Saudi Female
Sign Up to like & getrecommendations! Published in 2023 at "Case Reports in Medicine"
DOI: 10.1155/2023/8872346
Abstract: Antithrombin (AT) deficiency is a blood disorder associated with an increased tendency to form thrombosis. Hereditary AT deficiency is frequently caused by mutations in SERPINC1 gene. It is usually inherited as an autosomal dominant with… read more here.
Keywords: serpinc1 gene; antithrombin deficiency; mutation; gene ... See more keywords
Heparin Resistance due to an Acquired Antithrombin Deficiency in a Patient With Sickle Cell Disease During a Pregnancy Complicated by Bilateral Pulmonary Emboli: A Case Report.
Sign Up to like & getrecommendations! Published in 2019 at "A&A Practice"
DOI: 10.1213/xaa.0000000000000917
Abstract: We report a 31-year-old woman with sickle beta thalassemia zero who presented at 21 weeks gestational age with multiple bilateral pulmonary emboli and no hemodynamic instability. Acquired antithrombin deficiency was suspected due to a refractory… read more here.
Keywords: acquired antithrombin; report; bilateral pulmonary; antithrombin deficiency ... See more keywords
Rivaroxaban for Venous Thrombosis in a Patient with Congenital Antithrombin Deficiency.
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DOI: 10.1536/ihj.24-370
Abstract: Congenital antithrombin (AT) deficiency is a congenital coagulopathy that predisposes to venous thromboembolism (VTE), although the number of reported patients is limited; thus, large-scale data on the efficacy of direct oral anticoagulants (DOACs) in this… read more here.
Keywords: rivaroxaban venous; antithrombin deficiency; congenital antithrombin; venous thrombosis ... See more keywords
MPI-CDG with transient hypoglycosylation and antithrombin deficiency
Sign Up to like & getrecommendations! Published in 2018 at "Haematologica"
DOI: 10.3324/haematol.2018.211326
Abstract: Antithrombin deficiency is a strong risk factor for venous thromboembolism (VTE) whose testing has demonstrated usefulness.[1][1]–[5][2] Most cases of antithrombin deficiency are explained by mutations in SERPINC1 , the gene encoding this anticoagulant, with detection… read more here.
Keywords: transient hypoglycosylation; mpi cdg; hypoglycosylation antithrombin; antithrombin deficiency ... See more keywords