Death by translation: ribosome‐assisted degradation of mRNA by endonuclease toxins
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12715
Abstract: Like other forms of life, bacteria utilize a variety of mechanisms to survive stress. Some of these mechanisms mitigate the physiological impact of the stress, whereas others enable cells to simply wait out the stressful… read more here.
Keywords: endonuclease; yhav; stress; toxin ... See more keywords
Investigating the role of Bacillus subtilis type II toxin-antitoxin system in drought stress survival.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of basic microbiology"
DOI: 10.1002/jobm.202300120
Abstract: Toxin-antitoxin (TA) systems, present in plasmids and bacterial chromosomes, are widespread in bacteria such as Bacillus subtilis and are known to be involved in growth regulation, bacterial tolerance to environmental stress conditions as well as… read more here.
Keywords: stress; 548 ethylene; toxin; antitoxin ... See more keywords
In Silico Insight into the Dominant Type II Toxin–Antitoxin Systems and Clp Proteases in Listeria monocytogenes and Designation of Derived Peptides as a Novel Approach to Interfere with this System
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-019-09868-6
Abstract: Persisters are a variant of bacteria responsible for non-inherited antibiotic resistance and tolerance. Listeria monocytogenes is a predominant food-borne pathogen causing listeriosis. Persister cell formation in L. monocytogenes population may be explained by the presence… read more here.
Keywords: antitoxin; novel approach; antitoxin systems; toxin antitoxin ... See more keywords
The E. coli HicB Antitoxin Contains a Structurally Stable Helix-Turn-Helix DNA Binding Domain.
Sign Up to like & getrecommendations! Published in 2019 at "Structure"
DOI: 10.1016/j.str.2019.08.008
Abstract: The E. coli hicAB type II toxin-antitoxin locus is unusual by being controlled by two promoters and by having the toxin encoded upstream of the antitoxin. HicA toxins contain a double-stranded RNA-binding fold and cleaves… read more here.
Keywords: binding domain; antitoxin; helix; dna binding ... See more keywords
Discovery of Novel Spiropiperidinyl-α-methylene-γ-butyrolactones as Antifungal and Antitoxin Agents Targeting Oxysterol Binding Protein.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.4c02848
Abstract: Corn ear rot and fumonisin caused by Fusarium verticillioides pose a serious threat to food security. To find more highly active fungicidal and antitoxic candidates with structure diversity based on naturally occurring lead xanthatin, a… read more here.
Keywords: methylene butyrolactones; methylene; novel spiropiperidinyl; antitoxin ... See more keywords
Bacterial Genome Editing via a Designed Toxin-Antitoxin Cassette.
Sign Up to like & getrecommendations! Published in 2018 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.6b00287
Abstract: Manipulating the bacterial genomes in an efficient manner is essential to biological and biotechnological research. Here, we reprogrammed the bacterial TA systems as the toxin counter-selectable cassette regulated by an antitoxin switch (TCCRAS) for genetic… read more here.
Keywords: genome editing; cassette; bacterial genome; editing via ... See more keywords
Crosstalk between inovirus core gene and accessory toxin-antitoxin system mediates polylysogeny
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-62378-6
Abstract: Polylysogeny, the harboring of multiple prophages within a single bacterial genome, is common among bacterial pathogens and enhances virulence and genome plasticity. Inoviruses (filamentous phages) are often present in multiple copies in major pathogens, leading… read more here.
Keywords: core; antitoxin; toxin antitoxin; crosstalk ... See more keywords
Mechanisms of neutralization of toxSAS from toxin–antitoxin modules
Sign Up to like & getrecommendations! Published in 2024 at "Nature Chemical Biology"
DOI: 10.1038/s41589-024-01630-4
Abstract: Toxic small alarmone synthetase (toxSAS) enzymes constitute a family of bacterial effectors present in toxin–antitoxin and secretion systems. toxSASs act through either translation inhibition mediated by pyrophosphorylation of transfer RNA (tRNA) CCA ends or synthesis… read more here.
Keywords: neutralization; toxin antitoxin; antitoxin modules; toxin ... See more keywords
The bacterial Type III toxin-antitoxin system, ToxIN, is a dynamic protein-RNA complex with stability-dependent antiviral abortive infection activity
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-18696-x
Abstract: Bacteria have evolved numerous defense systems to protect themselves from viral (bacteriophage) infection. The ToxIN system of Pectobacterium atrosepticum is a Type III toxin-antitoxin complex and “altruistic suicide” anti-phage system, which kills phage-infected cells through… read more here.
Keywords: system; toxn; phage; infection ... See more keywords
ClpAP protease is a universal factor that activates the parDE toxin-antitoxin system from a broad host range RK2 plasmid
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33726-y
Abstract: The activity of type II toxin-antitoxin systems (TA), which are responsible for many important features of bacterial cells, is based on the differences between toxin and antitoxin stabilities. The antitoxin lability results from bacterial protease… read more here.
Keywords: toxin antitoxin; toxin; antitoxin; clpap protease ... See more keywords
Pediatric Botulism and Use of Equine Botulinum Antitoxin in Children: A Systematic Review
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Infectious Diseases"
DOI: 10.1093/cid/cix812
Abstract: Background Botulism manifests with cranial nerve palsies and flaccid paralysis in children and adults. Botulism must be rapidly identified and treated; however, clinical presentation and treatment outcomes of noninfant botulism in children are not well… read more here.
Keywords: pediatric botulism; botulism; botulinum antitoxin; review ... See more keywords