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   Articles with "antitoxin systems" as a keyword



Evolutionary history of Caulobacter toxin-antitoxin systems.

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recommendations! Published in 2021 at "Current microbiology"

DOI: 10.1007/s00284-021-02549-y

Abstract: Toxin-antitoxin (TA) systems have been studied in many bacterial genera, but a clear understanding of the evolutionary trajectory of TA operons has not emerged. To address this issue, I identified 42 distinct TA operons in… read more here.

Keywords: toxin antitoxin; location; antitoxin systems; caulobacter ... See more keywords

In Silico Derived Peptides for Inhibiting the Toxin–Antitoxin Systems of Mycobacterium tuberculosis: Basis for Developing Peptide-Based Therapeutics

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recommendations! Published in 2018 at "International Journal of Peptide Research and Therapeutics"

DOI: 10.1007/s10989-018-9792-8

Abstract: Toxin–antitoxin (TA) systems of Mycobacterium tuberculosis (Mtb) is a prerequisite for the bacterium to survive in extreme conditions. Antimicrobial peptides inhibiting the formation of these complexes provide a novel strategy for TB drug discovery process.… read more here.

Keywords: antitoxin systems; systems mycobacterium; derived peptides; silico derived ... See more keywords

In Silico Insight into the Dominant Type II Toxin–Antitoxin Systems and Clp Proteases in Listeria monocytogenes and Designation of Derived Peptides as a Novel Approach to Interfere with this System

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recommendations! Published in 2019 at "International Journal of Peptide Research and Therapeutics"

DOI: 10.1007/s10989-019-09868-6

Abstract: Persisters are a variant of bacteria responsible for non-inherited antibiotic resistance and tolerance. Listeria monocytogenes is a predominant food-borne pathogen causing listeriosis. Persister cell formation in L. monocytogenes population may be explained by the presence… read more here.

Keywords: antitoxin; novel approach; antitoxin systems; toxin antitoxin ... See more keywords
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Stress Can Induce Transcription of Toxin-Antitoxin Systems without Activating Toxin.

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recommendations! Published in 2020 at "Molecular cell"

DOI: 10.1016/j.molcel.2020.05.028

Abstract: Toxin-antitoxin (TA) systems are ubiquitous genetic elements in bacterial genomes, but their functions are controversial. Although they are frequently postulated to regulate cell growth following stress, few null phenotypes for TA systems have been reported.… read more here.

Keywords: transcription; antitoxin systems; stress; toxin ... See more keywords

Why so narrow: Distribution of anti-sense regulated, type I toxin-antitoxin systems compared with type II and type III systems

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recommendations! Published in 2017 at "RNA Biology"

DOI: 10.1080/15476286.2016.1272747

Abstract: ABSTRACT Toxin-antitoxin (TA) systems are gene modules that appear to be horizontally mobile across a wide range of prokaryotes. It has been proposed that type I TA systems, with an antisense RNA-antitoxin, are less mobile… read more here.

Keywords: antitoxin systems; toxin; type; toxin antitoxin ... See more keywords

Toxin-Antitoxin Systems Reflect Community Interactions Through Horizontal Gene Transfer

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recommendations! Published in 2024 at "Molecular Biology and Evolution"

DOI: 10.1093/molbev/msae206

Abstract: Abstract Bacterial evolution through horizontal gene transfer (HGT) reflects their community interactions. In this way, HGT networks do well at mapping community interactions, but offer little toward controlling them—an important step in the translation of… read more here.

Keywords: community interactions; toxin antitoxin; gene transfer; community ... See more keywords

Profiling the intragenic toxicity determinants of toxin–antitoxin systems: revisiting hok/Sok regulation

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac940

Abstract: Abstract Type I toxin–antitoxin systems (T1TAs) are extremely potent bacterial killing systems difficult to characterize using classical approaches. To assess the killing capability of type I toxins and to identify mutations suppressing the toxin expression… read more here.

Keywords: toxin antitoxin; hok sok; antitoxin systems; regulation ... See more keywords

IS26-mediated plasmid reshuffling results in convergence of toxin–antitoxin systems but loss of resistance genes in XDR Klebsiella pneumoniae from a chronic infection

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recommendations! Published in 2022 at "Microbial Genomics"

DOI: 10.1099/mgen.0.000892

Abstract: Carbapenem-resistant Enterobacterales pose an urgent threat to human health worldwide. Klebsiella pneumoniae sequence type (ST) 14, initially identified in the Middle East and South-Asia and co-harbouring the carbapenemase genes bla OXA-232 and bla NDM-1, is… read more here.

Keywords: toxin antitoxin; klebsiella pneumoniae; bla; antitoxin systems ... See more keywords
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Global Analysis of the Specificities and Targets of Endoribonucleases from Escherichia coli Toxin-Antitoxin Systems

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recommendations! Published in 2021 at "mBio"

DOI: 10.1128/mbio.02012-21

Abstract: Toxin-antitoxin (TA) systems are widespread genetic modules found in almost all bacteria that can regulate their growth and may play prominent roles in phage defense. Escherichia coli encodes 11 TA systems in which the toxin… read more here.

Keywords: global analysis; antitoxin systems; toxin antitoxin; escherichia coli ... See more keywords

Analysis of co-occurrence of type II toxin–antitoxin systems and antibiotic resistance determinants in Staphylococcus aureus

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recommendations! Published in 2025 at "mSystems"

DOI: 10.1128/msystems.00957-24

Abstract: ABSTRACT Toxin–antitoxin (TA) systems consist of toxic proteins and their inhibitors, and were originally shown to ensure plasmid maintenance in bacterial populations. Over time, however, TA systems have also been identified on bacterial chromosomes, raising… read more here.

Keywords: resistance; systems determinants; toxin antitoxin; antibiotic resistance ... See more keywords

Toxin-Antitoxin Systems Alter Adaptation of Mycobacterium smegmatis to Environmental Stress

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recommendations! Published in 2022 at "Microbiology Spectrum"

DOI: 10.1128/spectrum.02815-22

Abstract: Toxin-antitoxin (TA) systems are mechanisms for rapid adaptation of bacteria to environmental changes. Mycobacterium smegmatis, a model bacterium for studying Mycobacterium tuberculosis, encodes eight putative TA systems. Here, we constructed an M. smegmatis mutant with… read more here.

Keywords: toxin antitoxin; toxin; antitoxin systems; smegmatis ... See more keywords