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Published in 2021 at "Current microbiology"
DOI: 10.1007/s00284-021-02549-y
Abstract: Toxin-antitoxin (TA) systems have been studied in many bacterial genera, but a clear understanding of the evolutionary trajectory of TA operons has not emerged. To address this issue, I identified 42 distinct TA operons in…
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Keywords:
toxin antitoxin;
location;
antitoxin systems;
caulobacter ... See more keywords
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Published in 2018 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-018-9792-8
Abstract: Toxin–antitoxin (TA) systems of Mycobacterium tuberculosis (Mtb) is a prerequisite for the bacterium to survive in extreme conditions. Antimicrobial peptides inhibiting the formation of these complexes provide a novel strategy for TB drug discovery process.…
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Keywords:
antitoxin systems;
systems mycobacterium;
derived peptides;
silico derived ... See more keywords
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Published in 2019 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-019-09868-6
Abstract: Persisters are a variant of bacteria responsible for non-inherited antibiotic resistance and tolerance. Listeria monocytogenes is a predominant food-borne pathogen causing listeriosis. Persister cell formation in L. monocytogenes population may be explained by the presence…
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Keywords:
antitoxin;
novel approach;
antitoxin systems;
toxin antitoxin ... See more keywords
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Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.05.028
Abstract: Toxin-antitoxin (TA) systems are ubiquitous genetic elements in bacterial genomes, but their functions are controversial. Although they are frequently postulated to regulate cell growth following stress, few null phenotypes for TA systems have been reported.…
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Keywords:
transcription;
antitoxin systems;
stress;
toxin ... See more keywords
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Published in 2017 at "RNA Biology"
DOI: 10.1080/15476286.2016.1272747
Abstract: ABSTRACT Toxin-antitoxin (TA) systems are gene modules that appear to be horizontally mobile across a wide range of prokaryotes. It has been proposed that type I TA systems, with an antisense RNA-antitoxin, are less mobile…
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Keywords:
antitoxin systems;
toxin;
type;
toxin antitoxin ... See more keywords
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Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac940
Abstract: Abstract Type I toxin–antitoxin systems (T1TAs) are extremely potent bacterial killing systems difficult to characterize using classical approaches. To assess the killing capability of type I toxins and to identify mutations suppressing the toxin expression…
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Keywords:
toxin antitoxin;
hok sok;
antitoxin systems;
regulation ... See more keywords
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Published in 2022 at "Microbial Genomics"
DOI: 10.1099/mgen.0.000892
Abstract: Carbapenem-resistant Enterobacterales pose an urgent threat to human health worldwide. Klebsiella pneumoniae sequence type (ST) 14, initially identified in the Middle East and South-Asia and co-harbouring the carbapenemase genes bla OXA-232 and bla NDM-1, is…
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Keywords:
toxin antitoxin;
klebsiella pneumoniae;
bla;
antitoxin systems ... See more keywords
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Published in 2021 at "mBio"
DOI: 10.1128/mbio.02012-21
Abstract: Toxin-antitoxin (TA) systems are widespread genetic modules found in almost all bacteria that can regulate their growth and may play prominent roles in phage defense. Escherichia coli encodes 11 TA systems in which the toxin…
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Keywords:
global analysis;
antitoxin systems;
toxin antitoxin;
escherichia coli ... See more keywords
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Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02815-22
Abstract: Toxin-antitoxin (TA) systems are mechanisms for rapid adaptation of bacteria to environmental changes. Mycobacterium smegmatis, a model bacterium for studying Mycobacterium tuberculosis, encodes eight putative TA systems. Here, we constructed an M. smegmatis mutant with…
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Keywords:
toxin antitoxin;
toxin;
antitoxin systems;
smegmatis ... See more keywords
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Published in 2021 at "PLoS genetics"
DOI: 10.1371/journal.pgen.1009365
Abstract: Mycoplasmas are minute bacteria controlled by very small genomes ranging from 0.6 to 1.4 Mbp. They encompass several important medical and veterinary pathogens that are often associated with a wide range of chronic diseases. The…
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Keywords:
subsp capri;
toxin antitoxin;
mycoides subsp;
antitoxin systems ... See more keywords
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Published in 2017 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2017.01965
Abstract: Enzymes containing the FIC (filamentation induced by cyclic AMP) domain catalyze post-translational modifications of target proteins. In bacteria the activity of some Fic proteins resembles classical toxin–antitoxin (TA) systems. An excess of toxin over neutralizing…
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Keywords:
fic proteins;
antitoxin systems;
fic;
toxin antitoxin ... See more keywords