Synthesis, characterization and in vitro antitrypanosomal activities of new carboxamides bearing quinoline moiety
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0191234
Abstract: The reported toxicities of current antitrypanosomal drugs and the emergence of drug resistant trypanosomes underscore the need for the development of new antitrypanosomal agents. We report herein the synthesis and antitrypanosomal activity of 24 new… read more here.
Keywords: antitrypanosomal activities; activities new; characterization vitro; new carboxamides ... See more keywords
Potent Antitrypanosomal Activities of 3-Aminosteroids against African Trypanosomes: Investigation of Cellular Effects and of Cross-Resistance with Existing Drugs
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DOI: 10.3390/molecules24020268
Abstract: Treatment of animal African trypanosomiasis (AAT) requires urgent need for safe, potent and affordable drugs and this has necessitated this study. We investigated the trypanocidal activities and mode of action of selected 3-aminosteroids against Trypanosoma… read more here.
Keywords: potent antitrypanosomal; trypanosomes investigation; antitrypanosomal activities; activities aminosteroids ... See more keywords