Pyrimido[5,4-d]pyrimidine-Based Compounds as a Novel Class of Antitrypanosomal and Antileishmanial Agents.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00170
Abstract: Sleeping sickness and leishmaniasis are neglected tropical diseases that threaten millions of people. The currently available therapies present several limitations, including high toxicity, lack of efficacy, and emerging drug resistance, prompting a search for novel… read more here.
Keywords: antitrypanosomal antileishmanial; antileishmanial agents; pyrimido pyrimidine; novel class ... See more keywords
Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles.
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DOI: 10.1039/c7md00008a
Abstract: A series of prenyl 1,2,3-triazoles were prepared from isoprenyl azides and different alkynes. The dipolar cycloaddition reaction provided exclusively primary azide products as regioisomeric mixtures that were separated by column chromatography and fully characterized. Most… read more here.
Keywords: antitrypanosomal antileishmanial; prenyl triazoles; activity prenyl; prenyl ... See more keywords
Antitrypanosomal and Antileishmanial Activity of Chalcones and Flavanones from Polygonum salicifolium
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DOI: 10.3390/pathogens10020175
Abstract: Trypanosomiasis and leishmaniasis are a group of neglected parasitic diseases caused by several species of parasites belonging to the family Trypansomatida. The present study investigated the antitrypanosomal and antileishmanial activity of chalcones and flavanones from… read more here.
Keywords: salicifolium; activity chalcones; antitrypanosomal antileishmanial; chalcones flavanones ... See more keywords