Design, synthesis, and antitubercular activity of 3‐amidophenols with 5‐heteroatomic substitutions
Sign Up to like & getrecommendations! Published in 2019 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201800277
Abstract: A series of novel 3‐amidophenols with 5‐heteroatomic substitutions were designed and synthesized. Several compounds showed potent antitubercular activity against Mycobacterium tuberculosis H37Ra (MIC = 0.25–5 μg/mL). Compounds 12j and 14i also displayed good inhibitory activity against M. tuberculosis… read more here.
Keywords: design synthesis; heteroatomic substitutions; activity; synthesis antitubercular ... See more keywords
Synthesis and Antitubercular activity of New Thiazolidinones with Pyrazinyl and Thiazolyl scaffolds: New Thiazolidinones with Pyrazinyl and Thiazolyl scaffolds
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DOI: 10.1002/jhet.2552
Abstract: Emergence of multidrug resistant and extensively drug resistant tuberculosis has prompted to develop new molecular entities to treat the disease. A series of new 4-thiazolidinones with pyrazinyl and thiazolyl scaffolds has been synthesized, and their… read more here.
Keywords: new thiazolidinones; pyrazinyl thiazolyl; thiazolyl scaffolds; thiazolidinones pyrazinyl ... See more keywords
Antitubercular activity of 1,2,3-triazolyl fatty acid derivatives.
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DOI: 10.1016/j.ejmech.2016.09.086
Abstract: A collection of 1,2,3-triazoles unsaturated fatty acid mimics were efficiently synthesized by click chemistry. The 1,4-disubstituted analogs prepared covered different alkyl chain lengths and triazole positions. The compounds were subsequently tested against Mycobacterium tuberculosis, being… read more here.
Keywords: fatty acid; chemistry; antitubercular activity; activity triazolyl ... See more keywords
New benzothiazinone linked 1, 2, 4-triazoles: Design, synthesis, characterization, and evaluation of antitubercular activity
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DOI: 10.7324/japs.2021.110204
Abstract: Introduction: In a quest for developing active molecules to treat tuberculosis, we reported the design, synthesis, and antitubercular activity evaluation of benzo[1, 4]thiazin-3(4H)-one encompassed 1, 2, 4-triazoles targeting the DprE1 (Decaprenylphosphoryl-beta-D-ribose oxidase) enzyme involved in… read more here.
Keywords: evaluation; design synthesis; activity; new benzothiazinone ... See more keywords