New insights into the chemical behavior of S-oxide derivatives of thiocarbonyl-containing antitubercular drugs and the influence on their mechanisms of action and toxicity.
Sign Up to like & getrecommendations! Published in 2019 at "Annales pharmaceutiques francaises"
DOI: 10.1016/j.pharma.2018.11.004
Abstract: OBJECTIVES This work aims at getting more insights into the distinct behavior of S-oxide derivatives of thiocarbonyl-containing antitubercular drugs, in order to better understand their mechanism of action and toxicity. METHODS Computational calculation of relative… read more here.
Keywords: antitubercular drugs; action toxicity; sulfenic acid; oxide derivatives ... See more keywords
Antitubercular drugs induced liver injury: an updated insight into molecular mechanisms.
Sign Up to like & getrecommendations! Published in 2023 at "Drug metabolism reviews"
DOI: 10.1080/03602532.2023.2215478
Abstract: Tuberculosis (TB) remains a major global health burden. Antitubercular drugs (ATDs) such as isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA), and ethambutol are used as first-line therapy in TB patients. Drug-induced liver injury is one of… read more here.
Keywords: liver injury; rif; induced liver; antitubercular drugs ... See more keywords