Pharmacokinetics and Pharmacodynamics of Intensive Antituberculosis Treatment of Tuberculous Meningitis
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1783
Abstract: The most effective antituberculosis drug treatment regimen for tuberculous meningitis is uncertain. We conducted a randomized controlled trial comparing standard treatment with a regimen intensified by rifampin 15 mg/kg and levofloxacin for the first 60… read more here.
Keywords: treatment; exposure; hour range; antituberculosis ... See more keywords
Synthesis and in vitro evaluation of substituted 3-cinnamoyl-4-hydroxy-pyran-2-one (CHP) in pursuit of new potential antituberculosis agents.
Sign Up to like & getrecommendations! Published in 2018 at "MedChemComm"
DOI: 10.1039/c7md00366h
Abstract: Tuberculosis is an ever-evolving infectious disease that urgently needs new drugs. In the search for new antituberculosis agents, a library of 3-cinnamoyl-4-hydroxy-6-methyl-2H-pyran-2-ones (CHPs) (2a-2y) was synthesized and evaluated against a standard virulent laboratory strain of… read more here.
Keywords: antituberculosis agents; evaluation; antituberculosis; pyran ... See more keywords
Impact of nursing interventions on adherence to treatment with antituberculosis drugs in children and young people: A nonrandomized controlled trial
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Advanced Nursing"
DOI: 10.1111/jan.13692
Abstract: AIM To evaluate the association of a new nursing intervention on the adherence to antituberculosis treatment in a paediatric cohort ( read more here.
Keywords: intervention; phase; treatment; tuberculosis ... See more keywords
Hospitalized pediatric antituberculosis drug induced hepatotoxicity: Experience of an Indonesian referral hospital
Sign Up to like & getrecommendations! Published in 2017 at "Asian Pacific Journal of Tropical Disease"
DOI: 10.12980/apjtd.7.2017d6-402
Abstract: Childhood TB along with the adverse effect of its treatment is a major health burden. Approximately one million children were diagnosed with TB worldwide in 2014, with Indonesia ranking second after India amongst countries with… read more here.
Keywords: induced hepatotoxicity; drug induced; antituberculosis drug; hepatotoxicity ... See more keywords
Safety Evaluation of Antituberculosis Drugs During Pregnancy: A Systematic Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Surgery"
DOI: 10.3389/fsurg.2022.871321
Abstract: Background Pregnant women are a common group of people with tuberculosis,especially in patients infected with HIV at the same time. Antituberculosis drug prophylaxis is effective in reducing tuberculosis infection in pregnant women and fetuses after… read more here.
Keywords: drugs pregnancy; antituberculosis drugs; meta analysis; antituberculosis ... See more keywords
3-(5-Nitrofuran-2-yl)prop-2-en-1-one Derivatives, with Potent Antituberculosis Activity, Inhibit A Novel Therapeutic Target, Arylamine N-acetyltransferase, in Mycobacteria
Sign Up to like & getrecommendations! Published in 2020 at "Antibiotics"
DOI: 10.3390/antibiotics9070368
Abstract: In this study, the inhibitory potential of 3-(5-nitrofuran-2-yl)prop-2-en-1-one derivatives was evaluated against a panel of bacteria, as well as mammalian cell lines to determine their therapeutic index. In addition, we investigated the mechanism of antibiotic… read more here.
Keywords: nitrofuran prop; one derivatives; target; prop one ... See more keywords
Human Cytochrome P450 1, 2, 3 Families as Pharmacogenes with Emphases on Their Antimalarial and Antituberculosis Drugs and Prevalent African Alleles
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043383
Abstract: Precision medicine gives individuals tailored medical treatment, with the genotype determining the therapeutic strategy, the appropriate dosage, and the likelihood of benefit or toxicity. Cytochrome P450 (CYP) enzyme families 1, 2, and 3 play a… read more here.
Keywords: cyp; antituberculosis drugs; antimalarial antituberculosis; cytochrome p450 ... See more keywords