Dual-Mechanism Confers Self-Resistance to the Antituberculosis Antibiotic Capreomycin.
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DOI: 10.1021/acschembio.1c00799
Abstract: Capreomycin (CMN) is an important second-line antituberculosis antibiotic isolated from Saccharothrix mutabilis subspecies capreolus. The gene cluster for CMN biosynthesis has been identified and sequenced, wherein the cph gene was annotated as a phosphotransferase likely… read more here.
Keywords: antituberculosis antibiotic; resistance; self resistance; cmn iia ... See more keywords