NAT2 and CYP2E1 polymorphisms and antituberculosis drug‐induced hepatotoxicity in Peruvian patients
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1987
Abstract: In Peru, 32,970 people were diagnosed with tuberculosis (TB) in 2019. Although TB treatment is effective, 3.4%–13% is associated with significant adverse drug reactions (ADR), considering drug‐induced liver injury (DILI) as the most prevalent. Among… read more here.
Keywords: drug induced; cyp2e1 polymorphisms; nat2 cyp2e1; antituberculosis drug ... See more keywords
Three-component green synthesis of 6-ethoxycarbonyl-5-methyl-7-(thien-2-yl)-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine, a promising antituberculosis drug
Sign Up to like & getrecommendations! Published in 2019 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-019-2698-6
Abstract: A new simple, technological, and environmentally friendly method for the catalyst-free synthesis in water of a promising antituberculosis drug, 6-ethoxycarbonyl-5-methyl-7-(thien-2-yl)-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine, was developed. The amount of the solvent in the reaction mixture has a decisive effect… read more here.
Keywords: methyl thien; dihydro triazolo; antituberculosis drug; thien dihydro ... See more keywords
Distribution scheme of antituberculosis drug resistance among HIV patients in a referral centre over 10 years.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2017.06.010
Abstract: OBJECTIVES Antituberculosis drug resistance is increasing among tuberculosis (TB) patients globally, particularly in those who are human immunodeficiency virus (HIV)-positive. The aim of this study was to determine the pattern of anti-TB drug resistance in… read more here.
Keywords: drug resistance; among hiv; treatment; antituberculosis drug ... See more keywords
Mechanochemically synthesized poly(o-toluidine)-intercalated montmorillonite nanocomposites as antituberculosis drug carriers
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DOI: 10.1080/00914037.2017.1320658
Abstract: ABSTRACT The present preliminary study reports the synthesis of montmorillonite (MMT)/poly(o-toluidine) (PoTD) nanocomposites prepared by confining PoTD in the galleries of MMT. X-ray diffraction confirmed the intercalation of PoTD at 25°C, while exfoliation was observed… read more here.
Keywords: drug; antituberculosis drug; mechanochemically synthesized; poly toluidine ... See more keywords
Genomewide Association Study Confirming the Association of NAT2 with Susceptibility to Antituberculosis Drug-Induced Liver Injury in Thai Patients
Sign Up to like & getrecommendations! Published in 2019 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02692-18
Abstract: Antituberculosis drug-induced liver injury (ATDILI) is a common side effect leading to tuberculosis (TB) treatment disruption. The mechanism of the disease remains poorly understood. We conducted a genomewide association study (GWAS) to investigate all possible… read more here.
Keywords: antituberculosis drug; induced liver; association; thai patients ... See more keywords
Hospitalized pediatric antituberculosis drug induced hepatotoxicity: Experience of an Indonesian referral hospital
Sign Up to like & getrecommendations! Published in 2017 at "Asian Pacific Journal of Tropical Disease"
DOI: 10.12980/apjtd.7.2017d6-402
Abstract: Childhood TB along with the adverse effect of its treatment is a major health burden. Approximately one million children were diagnosed with TB worldwide in 2014, with Indonesia ranking second after India amongst countries with… read more here.
Keywords: induced hepatotoxicity; drug induced; antituberculosis drug; hepatotoxicity ... See more keywords
Antituberculosis Drug Resistance in Pulmonary Isolates of Mycobacterium tuberculosis, Cuba 2012-2014.
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DOI: 10.1590/medicc.2017.190100005
Abstract: INTRODUCTION Systematic surveillance of antituberculosis drug resistance allows identification of multidrug-resistant and extensively drug-resistant isolates of Mycobacterium tuberculosis. Surveillance studies of antituberculosis drug resistance systematically conducted in Cuba for over 15 years have revealed low… read more here.
Keywords: drug resistance; drug; antituberculosis drug; tuberculosis ... See more keywords