Near‐Infrared Triggered Cascade of Antitumor Immune Responses Based on the Integrated Core–Shell Nanoparticle
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202000335
Abstract: The clinical application of antitumor immunotherapy still faces severe challenges related to efficacy. Here, a light‐triggered core–shell nanosystem is designed to boost antitumor immune response via controlled release of anti‐PD‐L1 (αPD‐L1) antibodies and enhanced antigen… read more here.
Keywords: antitumor; antitumor immune; shell; near infrared ... See more keywords
Soft X-Ray Stimulated Lanthanide@MOF Nanoprobe for Amplifying Deep Tissue Synergistic Photodynamic and Antitumor Immunotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202101174
Abstract: Combining photodynamic therapy (PDT) and immunotherapy has shown profound impact for synergistic treatment of malignant tumors. However, the shallow penetration depth of the traditional visible light activated PDT, immunosuppressive tumor microenvironment (TME), and poor immunogenicity… read more here.
Keywords: deep tissue; immunotherapy; ray; pdt ... See more keywords
Platelet Pharmacytes for the Hierarchical Amplification of Antitumor Immunity in Response to Self‐Generated Immune Signals
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202109517
Abstract: Systemic immunosuppression mediated by tumor‐derived exosomes is an important cause for the resistance of immune checkpoint blockade (ICB) therapy. Herein, self‐adaptive platelet (PLT) pharmacytes are engineered to mediate cascaded delivery of exosome‐inhibiting siRNA and anti‐PD‐L1… read more here.
Keywords: pharmacytes hierarchical; antitumor; platelet pharmacytes; response ... See more keywords
Magnetic–Acoustic Sequentially Actuated CAR T Cell Microrobots for Precision Navigation and In Situ Antitumor Immunoactivation
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202211509
Abstract: Despite its clinical success, chimeric antigen receptor T (CAR T)‐cell immunotherapy remains limited in solid tumors, owing to the harsh physical barriers and immunosuppressive microenvironment. Here a CAR‐T‐cell‐based live microrobot (M‐CAR T) is created by… read more here.
Keywords: cell; antitumor; car; magnetic acoustic ... See more keywords
MXene-based Functional Platforms for Tumor Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202302559
Abstract: Recently, 2D transition metal carbide, nitride, and carbonitrides (MXenes) materials stand out in the field of tumor therapy, particularly in the construction of functional platforms for optimal antitumor therapy due to their high specific surface… read more here.
Keywords: based functional; antitumor; tumor therapy; therapy ... See more keywords
A Potent Micron Neoantigen Tumor Vaccine GP‐Neoantigen Induces Robust Antitumor Activity in Multiple Tumor Models
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202201496
Abstract: Therapeutic tumor neoantigen vaccines have been widely studied given their good safety profile and ability to avoid central thymic tolerance. However, targeting antigen‐presenting cells (APCs) and inducing robust neoantigen‐specific cellular immunity remain challenges. Here, a… read more here.
Keywords: system; antitumor; tumor; neoantigen ... See more keywords
Improving antitumor immunity using antiangiogenic agents: Mechanistic insights, current progress, and clinical challenges
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Communications"
DOI: 10.1002/cac2.12183
Abstract: Cancer immunotherapy, especially immune checkpoint blockade (ICB), has revolutionized oncology. However, only a limited number of patients benefit from immunotherapy, and some cancers that initially respond to immunotherapy can ultimately relapse and progress. Thus, some… read more here.
Keywords: immunity; cancer immunotherapy; antiangiogenic agents; cancer ... See more keywords
Synthesis, Antitumor of Sinomenine Derivatives and Apoptotic Induction via IL-6/PI3K/Akt/NF-κB Signaling Pathway in MCF-7 Cells.
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200234
Abstract: Natural products have been widely considered as an important resource for new drugs or lead compounds. Sinomenine (SIN) and its derivatives exert antitumor activity via regulation of inflammatory mediators. For these reasons we synthesized three… read more here.
Keywords: pi3k akt; apoptotic induction; antitumor; antitumor activity ... See more keywords
Carborane Analogues of Fenoprofen Exhibit Improved Antitumor Activity
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200583
Abstract: Fenoprofen is a widely used nonsteroidal anti‐inflammatory drug (NSAID) against rheumatoid arthritis, degenerative joint disease, ankylosing spondylitis and gout. Like other NSAIDs, fenoprofen inhibits the synthesis of prostaglandins by blocking both cyclooxygenase (COX) isoforms, COX‐1… read more here.
Keywords: analogues fenoprofen; antitumor; carborane analogues; exhibit improved ... See more keywords
The tumor microenvironment drives NK cell metabolic dysfunction leading to impaired antitumor activity
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34389
Abstract: NK cells represent key players capable of driving antitumor immune responses. However, the potent immunosuppressive activity of the tumor microenvironment (TME) may impair their effector function. Here, we strengthen the importance of metabolic interactions between… read more here.
Keywords: activity; antitumor; tumor microenvironment; metabolic dysfunction ... See more keywords
Synergistic antitumor effects of rhein and doxorubicin in hepatocellular carcinoma cells.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.27514
Abstract: The aim of this study was to investigate the synergistic antitumor activity of rhein and doxorubicin (DOX) and to elucidate the underlying mechanisms in hepatocellular SMMC-7721 and HepG2 cells. Cell growth curves, caspase-3 activity, and… read more here.
Keywords: hepatocellular carcinoma; synergistic antitumor; rhein doxorubicin; antitumor effects ... See more keywords