Pyrazolo[5,1-c][1,2,4]triazoles: Antimicrobial, Antitumor Activities, and Computational Docking Studies
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2892
Abstract: A new series of pyrazolotriazoles 7a–l, 11, and 15a–c derived from the reaction of 3-amino-4-(arylhydrazono)-4,5-dihydropyrazol-5-one 3a,b with various types of hydrazonoyl chlorides 4, 10, 12, and 13 was being synthesized in existence of triethylamine. The… read more here.
Keywords: antitumor activities; pyrazolo triazoles; triazoles antimicrobial; antimicrobial antitumor ... See more keywords
Antitumor Activities of Six Quassinoids from Ailanthus altissima
Sign Up to like & getrecommendations! Published in 2017 at "Chemistry of Natural Compounds"
DOI: 10.1007/s10600-017-1903-9
Abstract: Six known quassinoids were isolated from the bark of Ailanthus altissima. Their structures were elucidated by spectroscopic methods. Compounds 1–6 were screened for their antitumor activities evaluated by MTT assay. read more here.
Keywords: ailanthus altissima; quassinoids ailanthus; antitumor activities; chemistry ... See more keywords
Computational Analysis of Artimisinin Derivatives on the Antitumor Activities
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DOI: 10.1007/s13659-017-0142-x
Abstract: The study on antitumor activities of artemisinin and its derivatives has been closely focused on in recent years. Herein, 2D and 3D QSAR analysis was performed on the basis of a series of artemisinin derivatives… read more here.
Keywords: artimisinin derivatives; antitumor activities; analysis; computational analysis ... See more keywords
Structures and antitumor activities of ten new and twenty known surfactins from the deep-sea bacterium Limimaricola sp. SCSIO 53532.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105589
Abstract: Surfactins are natural biosurfactants with myriad potential applications in the areas of healthcare and environment. However, surfactins were almost exclusively produced by the bacterium Bacillus species in previous reported literatures, together with difficulty in isolating… read more here.
Keywords: ten new; known surfactins; twenty known; antitumor activities ... See more keywords
Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.05.072
Abstract: Microtubule is one of the important targets for cancer treatment. A novel class of diaryl substituted imidazo[4,5-c]pyridin-2-ones and imidazo[4,5-c]pyridines were designed based on combination principles by merging the structures of β-lactams and purine-type compounds known… read more here.
Keywords: diaryl substituted; antitumor activities; design synthesis; tubulin katanin ... See more keywords
Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00095
Abstract: Despite recent clinical progress in peptide-based dual inhibitors of MDM2/4, small-molecule ones with robust antitumor activities remain challenging. To tackle this issue, 31 (YL93) was structure-based designed and synthesized, which had MDM2/4 binding Ki values… read more here.
Keywords: dual inhibitors; mdm2; antitumor activities; mdm4 overexpressing ... See more keywords
Synthesis of novel isoindole-containing phakellistatin 2 analogs and the conformation features affecting their antitumor activities
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DOI: 10.1039/c9nj01832h
Abstract: Two novel phakellistatin 2 analogs were synthesized and the conformational features affecting their antitumor activities were studied. read more here.
Keywords: features affecting; affecting antitumor; antitumor activities; synthesis novel ... See more keywords
Exosomes derived from γδ-T cells synergize with radiotherapy and preserve antitumor activities against nasopharyngeal carcinoma in immunosuppressive microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003832
Abstract: Background Radiotherapy is the first-line treatment for patients nasopharyngeal carcinoma (NPC), but its therapeutic efficacy is poor in some patients due to radioresistance. Adoptive T cell-based immunotherapy has also shown promise to control NPC; however,… read more here.
Keywords: cell; microenvironment; radiotherapy; antitumor activities ... See more keywords
DS-7300a, a DNA Topoisomerase I Inhibitor, DXd-based Antibody-Drug Conjugate Targeting B7-H3 Exerts Potent Antitumor Activities in Preclinical Models.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cancer therapeutics"
DOI: 10.1158/1535-7163.mct-21-0554
Abstract: B7-H3 is overexpressed in various solid tumors and has been considered as an attractive target for cancer therapy. Here, we report the development of DS-7300a, a novel B7-H3-targeting antibody-drug conjugate with a potent DNA topoisomerase… read more here.
Keywords: antibody drug; drug conjugate; cancer; antitumor activities ... See more keywords
Influence of storage variables on the antioxidant and antitumor activities, phenolic compounds and vitamin C of an agglomerate of Andean berries.
Sign Up to like & getrecommendations! Published in 2023 at "Heliyon"
DOI: 10.2139/ssrn.4220980
Abstract: Berry consumption is increasing worldwide due to their high content of bioactive compounds. However, such fruits have a very short shelf life. To avoid this drawback and to offer an effective alternative for its consumption… read more here.
Keywords: antioxidant antitumor; storage variables; variables antioxidant; influence storage ... See more keywords
Ten-Gram-Scale Mechanochemical Synthesis of Ternary Lanthanum Coordination Polymers for Antibacterial and Antitumor Activities
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.898324
Abstract: As rare-earth coordination polymers (CPs) have appreciable antimicrobial properties, ternary lanthanum CPs have been widely synthesized and investigated in recent years. Here, we report convenient, solvent-free reactions between the lanthanum salt and two ligands at… read more here.
Keywords: gram scale; antitumor activities; ternary lanthanum; lanthanum ... See more keywords