Photothermal Therapy: Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells (Adv. Mater. 23/2019)
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DOI: 10.1002/adma.201970166
Abstract: CAR-T lymphocytes show modest therapeutic efficacy in solid tumors. Mild hyperthermia of the tumor reduces its compact structure and interstitial fluid pressure (IFP), increases blood perfusion, releases antigens, and promotes the recruitment of endogenous immune… read more here.
Keywords: car cells; therapy; photothermal therapy; antitumor activity ... See more keywords
Antitumor activity of celastrol by inhibition of proliferation, invasion, and migration in cholangiocarcinoma via PTEN/PI3K/Akt pathway
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DOI: 10.1002/cam4.2719
Abstract: Cholangiocarcinoma is a malignant tumor originating from bile duct epithelium. Currently, the treatment strategy is very limited and the prognosis is poor. Recent studies reported celastrol exhibits antigrowth and antimetastasis properties in many tumors. Our… read more here.
Keywords: proliferation invasion; celastrol inhibition; cholangiocarcinoma; antitumor activity ... See more keywords
Synthesis, Antitumor of Sinomenine Derivatives and Apoptotic Induction via IL-6/PI3K/Akt/NF-κB Signaling Pathway in MCF-7 Cells.
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DOI: 10.1002/cmdc.202200234
Abstract: Natural products have been widely considered as an important resource for new drugs or lead compounds. Sinomenine (SIN) and its derivatives exert antitumor activity via regulation of inflammatory mediators. For these reasons we synthesized three… read more here.
Keywords: pi3k akt; apoptotic induction; antitumor; antitumor activity ... See more keywords
ANTITUMOR ACTIVITY OF PEMBROLIZUMAB PLUS DINACICLIB IN PATIENTS WITH DIFFUSE LARGE B CELL LYMPHOMA: THE PHASE 1B KEYNOTE‐155 STUDY
Sign Up to like & getrecommendations! Published in 2019 at "Hematological Oncology"
DOI: 10.1002/hon.140_2630
Abstract: Tucson, United States; Medical Oncologist, Virginia Cancer Specialists, US Oncology Research, Woodbridge, United States; Hematology, Fred Hutchinson Cancer Research Center, Seattle, United States; Medical Oncology & Hematology, Northwest Cancer Specialists, US Oncology Research, Vancouver, United… read more here.
Keywords: antitumor activity; hematology; cancer; lymphoma ... See more keywords
Synthesis and antitumor activity evaluation of different 2,5-dialkyloxazolopyrano[3,2-c]quinolinone derivatives
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DOI: 10.1007/s00044-018-2259-9
Abstract: A new interesting family of 2,5-dialkyloxazolopyrano[3,2-c]quinolinone derivatives 4a-l were synthesized in good yields using a convenient and successful method. Structures of all compounds were achieved by elemental analyses, IR, 1H NMR, 13C NMR, and mass… read more here.
Keywords: dialkyloxazolopyrano quinolinone; quinolinone derivatives; antitumor activity;
Design, synthesis, and antitumor evaluation of novel naphthalimide derivatives
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DOI: 10.1007/s00044-019-02471-w
Abstract: In order to research the structure–activity relationships of novel naphthalimide derivatives bearing disulfide bond toward antitumor activity, we prepared a series of those and their in vitro antiproliferative activities were screened against human cancer cell… read more here.
Keywords: naphthalimide derivatives; antitumor activity; compounds showed; novel naphthalimide ... See more keywords
Probenecid increases renal retention and antitumor activity of DFMO in neuroblastoma
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DOI: 10.1007/s00280-021-04309-y
Abstract: Neuroblastoma (NB) is the most common extracranial solid tumor in children. Interference with the polyamine biosynthesis pathway by inhibition of MYCN-activated ornithine decarboxylase (ODC) is a validated approach. The ODC inhibitor α-difluoromethylornithine (DFMO, or Eflornithine)… read more here.
Keywords: probenecid; activity dfmo; dfmo; antitumor activity ... See more keywords
Targeting the WEE1 kinase strengthens the antitumor activity of imatinib via promoting KIT autophagic degradation in gastrointestinal stromal tumors
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DOI: 10.1007/s10120-019-00977-1
Abstract: Background Activating mutation of KIT or PDGFRA is the primary molecular mechanism for gastrointestinal stromal tumors (GISTs). Although imatinib has a revolutionary effect on GIST therapeutics, the benefits are not durable. Increasing reports have demonstrated… read more here.
Keywords: wee1; inhibition; antitumor activity; kit ... See more keywords
Antitumor Activity of Fascaplysin Derivatives on Glioblastoma Model In Vitro
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DOI: 10.1007/s10517-018-4055-4
Abstract: Antitumor efficiency of fascaplysin synthetic derivatives (7-phenylfascaplysin, 3-chlorofascaplysin, 3-bromofascaplysin, and 10-bromofascaplysin) was compared out in vitro on C6 glioma cells. The cytotoxic efficiency of all tested compounds was higher than that of unsubstituted fascaplysin; 3-bromofascaplysin… read more here.
Keywords: activity fascaplysin; glioma; fascaplysin derivatives; antitumor activity ... See more keywords
P2X7 receptor involved in antitumor activity of atractylenolide I in human cervical cancer cells.
Sign Up to like & getrecommendations! Published in 2022 at "Purinergic signalling"
DOI: 10.1007/s11302-022-09854-6
Abstract: Atractylenolide I (Atr-I) was found to sensitize a variety of human cancer cells in previous studies. Purinergic P2X7R plays important role in different cancers. However, whether Atr-I could generate antitumor activity in human cervical cancer… read more here.
Keywords: cancer; cervical cancer; cancer cells; antitumor activity ... See more keywords
Coadministration with bendamustine restores the antitumor activity of obinutuzumab in obinutuzumab-resistant tumors
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DOI: 10.1007/s12185-022-03320-0
Abstract: The glycoengineered, humanized anti-CD20 antibody obinutuzumab is indicated for previously untreated or relapsed/refractory CD20-positive follicular lymphoma (FL). However, the effectiveness of obinutuzumab retreatment in relapsed/refractory FL after prior obinutuzumab-containing therapy is unclear. To address this… read more here.
Keywords: obinutuzumab resistant; antitumor activity; day; resistant tumors ... See more keywords