Pt(IV) Prodrug as a Potential Antitumor Agent with APE1 Inhibitory Activity.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01318
Abstract: The base excision repair (BER) pathway is essential for cancer cells to resist chemotherapeutic treatment, but its significance is underrated. The present study describes a novel Pt(IV) prodrug, AP1, targeting a critical BER protein, apurinic/apyrimidinic… read more here.
Keywords: antitumor agent; agent ape1; activity; potential antitumor ... See more keywords
Ionic-Liquid-Catalyzed Access to CTr: An Antitumor Agent
Sign Up to like & getrecommendations! Published in 2021 at "ACS Sustainable Chemistry & Engineering"
DOI: 10.1021/acssuschemeng.1c00191
Abstract: CTr (5,6,11,12,17,18-hexahydrocyclononal[1,2-b:4,5-b′:7,8-b″]triindole) is a unique 9-membered indole-fused cycloalkane alkaloid with improved druglike privilege and therapeutic potential, but its ... read more here.
Keywords: ctr antitumor; liquid catalyzed; access ctr; antitumor agent ... See more keywords