Synthesis of novel cyanine dyes as antitumor agents
Sign Up to like & getrecommendations! Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202000186
Abstract: In this study, some novel cyanine dyes, 1, 3, and 5−15, were synthesized by a one‐pot step reaction of pyridinium salts 2 and/or 4 with benzenaminium salt 1. N‐{[1‐Chloro‐3,4‐dihydronaphthalen‐2‐yl)methylene]benzenaminium} chloride 1 was obtained by the… read more here.
Keywords: synthesis novel; dyes antitumor; novel cyanine; cyanine dyes ... See more keywords
Design, synthesis, cytotoxicity and 3D-QSAR analysis of new 3,6-disubstituted-1,2,4,5-tetrazine derivatives as potential antitumor agents
Sign Up to like & getrecommendations! Published in 2019 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2017.04.002
Abstract: Abstract We synthesized two new series of 3-substituted-6-(2,5-dimethylpyrazol-1-yl)-1,2,4,5-tetrazines and analysed them for a potential role as antitumor agents. Twenty-two compounds were obtained, and four molecular structures were determined by X-ray diffraction analysis. Using flow cytometry… read more here.
Keywords: tetrazine derivatives; qsar analysis; cell; analysis ... See more keywords
Exploration of certain 1,3-oxazole- and 1,3-thiazole-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103988
Abstract: Several novel series of hydroxamic acids bearing 2-benzamidooxazole/thiazole (5a-g, 6a-g) or 2-phenylsulfonamidothiazole (8a-c) were designed and synthesized. The compounds were obtained straightforwards via a two step pathway, starting from commercially available ethyl 2-aminooxazole-4-carboxylate or ethyl… read more here.
Keywords: based hydroxamic; inhibitors antitumor; hydroxamic acids; thiazole based ... See more keywords
Design, synthesis and pharmacological evaluation of new 3-(1H-benzimidazol-2-yl)quinolin-2(1H)-one derivatives as potential antitumor agents.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.07.066
Abstract: A series of new 3-(1H-benzimidazol-2-yl)quinolin-2(1H)-one derivatives (5a1-5d6) were designed and synthesized as antitumor agents. In vitro antitumor assay results showed that some compounds exhibited moderate to high inhibitory activity against HepG2, SK-OV-3, NCI-H460 and BEL-7404 tumor… read more here.
Keywords: benzimidazol quinolin; one derivatives; quinolin one; antitumor agents ... See more keywords
Practical synthesis of phthalascidin and zalypsis antitumor agents
Sign Up to like & getrecommendations! Published in 2021 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2021.153498
Abstract: Abstract The first total synthesis of zalypsis and the practical synthesis of phthalascidin (Pt-650) are achieved through the Pictet-Spengler cyclization coupling strategy. The direct iodination of the primary alcohol in trihydroxyl intermediate 26 followed by… read more here.
Keywords: synthesis; zalypsis; synthesis phthalascidin; practical synthesis ... See more keywords
Pt(II) versus Pt(IV) in Carbene Glycoconjugate Antitumor Agents: Minimal Structural Variations and Great Performance Changes
Sign Up to like & getrecommendations! Published in 2020 at "Inorganic Chemistry"
DOI: 10.1021/acs.inorgchem.9b03683
Abstract: Octahedral Pt(IV) complexes (2Pt–R) containing a glycoconjugate carbene ligand were prepared and fully characterized. These complexes are structural analogues to the trigonal bipyramidal Pt(II) species (1Pt–R) recently described. Thus, an unprecedented direct comparison between the… read more here.
Keywords: glycoconjugate antitumor; glycoconjugate; versus carbene; carbene glycoconjugate ... See more keywords
Evodiamine-Inspired Topoisomerase-Histone Deacetylase Dual Inhibitors: Novel Orally Active Antitumor Agents for Leukemia Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02026
Abstract: On the basis of the synergism of topoisomerase (Top) and histone deacetylase (HDAC) inhibitors in antitumor therapy, a series of novel Top/HDAC dual inhibitors were designed and synthesized by the pharmacophore fusion strategy. After systematic… read more here.
Keywords: histone deacetylase; orally active; antitumor; dual inhibitors ... See more keywords
Disaccharides obtained from carrageenans as potential antitumor agents
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-43238-y
Abstract: Carrageenans are sulfated galactans found in certain red seaweeds with proven biological activities. In this work, we have prepared purified native and degraded κ-, ι-; and λ-carrageenans, including the disaccharides (carrabioses) and disaccharide-alditols (carrabiitols) from… read more here.
Keywords: obtained carrageenans; carrageenans potential; antitumor agents; disaccharides obtained ... See more keywords
Synthesis and biological evaluation of terminal functionalized thiourea-containing dipeptides as antitumor agents
Sign Up to like & getrecommendations! Published in 2017 at "RSC Advances"
DOI: 10.1039/c6ra25590f
Abstract: A series of antitumor agents based on terminal functionalized dipeptide derivatives containing the thiourea moiety were synthesized and evaluated for antiproliferative activity using a panel of cancer cell lines, and the effects and mechanism of… read more here.
Keywords: biological evaluation; terminal functionalized; antitumor agents; evaluation terminal ... See more keywords
Design, synthesis and characterization of novel chromone based-copper(II) antitumor agents with N,N-donor ligands: comparative DNA/RNA binding profile and cytotoxicity
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c8ra06722h
Abstract: A series of new chromone based-Cu(II) complexes 1–3 derived from bioactive pharmacophore, 3-formylchromone and N,N-donor ligands viz., 1,10-phenanthroline, 2,2′-bipyridine and 1R,2R-DACH were synthesized as potential antitumor agents and thoroughly characterized by UV-vis, FT-IR, EPR, ESI-MS… read more here.
Keywords: donor ligands; antitumor agents; chromone based; dna ... See more keywords
Terpyridines as promising antitumor agents: an overview of their discovery and development
Sign Up to like & getrecommendations! Published in 2021 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2017877
Abstract: ABSTRACT Introduction The fused aromatic system of terpyridines makes them good, innocent ligands for various metals. The resulting complexes have been extensively studied for both their biological activity and physico-chemical properties. However, although free ligands… read more here.
Keywords: agents overview; promising antitumor; discovery; activity ... See more keywords