Antitumor and antiangiogenic effects of Tonantzitlolone B, an uncommon diterpene from Stillingia loranthacea
Sign Up to like & getrecommendations! Published in 2021 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-021-02185-0
Abstract: Natural products have played a pivotal role for the discovery of anticancer drugs. Tonantzitlolones are flexibilan-type diterpenes rare in nature; therefore, few reports have shown antiviral and cytotoxic activities. This study aimed to investigate the… read more here.
Keywords: tonantzitlolone uncommon; antiangiogenic effects; effects tonantzitlolone; antitumor antiangiogenic ... See more keywords
Discovery of novel tubulin/HDAC dual-targeting inhibitors with strong antitumor and antiangiogenic potency.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113790
Abstract: A novel series of cis-diphenylethene and benzophenone derivatives as tubulin/HDAC dual-targeting inhibitors were designed and synthesized. Among them, compound 28g exhibited the most potent antiproliferative activities against six different human cancer cell lines, 28g could… read more here.
Keywords: targeting inhibitors; tubulin hdac; dual targeting; antitumor antiangiogenic ... See more keywords