A SIRPα‐Fc fusion protein enhances the antitumor effect of oncolytic adenovirus against ovarian cancer
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12628
Abstract: Oncolytic viruses armed with therapeutic transgenes of interest show great potential in cancer immunotherapy. Here, a novel oncolytic adenovirus carrying a signal regulatory protein‐α (SIRPα)‐IgG1 Fc fusion gene (termed SG635‐SF) was constructed, which could block… read more here.
Keywords: protein; antitumor effect; fusion; oncolytic adenovirus ... See more keywords
The antitumor effect of static and extremely low frequency magnetic fields against nephroblastoma and neuroblastoma.
Sign Up to like & getrecommendations! Published in 2018 at "Bioelectromagnetics"
DOI: 10.1002/bem.22124
Abstract: Certain magnetic fields (MF) have potential therapeutic antitumor effect whereas the underlying mechanism remains undefined. In this study, a well-characterized MF was applied to two common childhood malignancies, nephroblastoma and neuroblastoma. This MF has a… read more here.
Keywords: extremely low; antitumor effect; magnetic fields; effect ... See more keywords
Bcl‐2/Bcl‐xl inhibitor APG‐1252‐M1 is a promising therapeutic strategy for gastric carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3090
Abstract: Gastric carcinoma is the third major cause of cancer‐related death in China. Bcl‐2 and other BH3 family proteins are critically important in the process of apoptosis pathway, which may be a promising target. APG‐1252‐M1 specifically… read more here.
Keywords: gastric carcinoma; antitumor effect; bcl bcl; apg 1252 ... See more keywords
EGCG enhances antitumor effect of apatinib in nonsmall cell lung cancer by targeting VEGF signaling to inhibit glycolysis
Sign Up to like & getrecommendations! Published in 2024 at "Drug Development Research"
DOI: 10.1002/ddr.22239
Abstract: Nonsmall cell lung cancer (NSCLC), one of the most aggressive malignancies globally, is characterized by poor prognosis and limited life expectancy. Epigallocatechin‐3‐gallate (EGCG), a natural polyphenol found in green tea, has emerged as a promising… read more here.
Keywords: nonsmall cell; cell; effect apatinib; antitumor effect ... See more keywords
Ficolin-2 triggers antitumor effect by activating macrophages and CD8+ T cells.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical immunology"
DOI: 10.1016/j.clim.2017.08.012
Abstract: Ficolin-2 is an important serum complement lectin. Here, we describe novel findings indicating that serum ficolin-2 concentrations in multiple tumor patients are significantly lower than those in healthy donors. Administration of exogenous ficolin-2 or ficolin-A… read more here.
Keywords: antitumor effect; cells ficolin; ficolin triggers; cd8 cells ... See more keywords
Selective Antitumor Effect and Lower Toxicity of Mitochondrion-Targeting Derivatization of Triptolide.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c01508
Abstract: Triptolide has a significant antitumor activity, but its toxicity limits its clinical application. As the mitochondrion-targeting strategy showed an advantage in selective antitumor effect based on the higher mitochondrial membrane potential (MMP) in tumor cells… read more here.
Keywords: mitochondrion targeting; selective antitumor; antitumor; toxicity ... See more keywords
Antitumor Effect of Photodynamic Therapy/Sonodynamic Therapy/Sono-Photodynamic Therapy of Chlorin e6 and Other Applications.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00824
Abstract: Chlorin e6 (Ce6) has been extensively researched and developed as an antitumor therapy. Ce6 is a highly effective photosensitizer and sonosensitizer with promising future applications in photodynamic therapy, dynamic acoustic therapy, and combined acoustic and… read more here.
Keywords: chlorin; therapy; photodynamic therapy; antitumor effect ... See more keywords
Antitumor Effect of Platinum-Modified STING Agonist MSA-2
Sign Up to like & getrecommendations! Published in 2024 at "ACS Omega"
DOI: 10.1021/acsomega.3c07498
Abstract: The stimulator of interferon genes (STING)-activated innate immune pathway is strong and durable for tumor immunotherapy. MSA-2 is an available non-nucleotide human STING agonist that promotes the tumor immunotherapy of STING activation. However, strategies for… read more here.
Keywords: msa; antitumor effect; platinum; sting agonist ... See more keywords
Poly(ethylene glycol)–poly(lysine) block copolymer–ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0406-x
Abstract: Previous studies highlighted that aminopeptidase N (APN)/CD13 acts as a scavenger in the survival of hepatocellular carcinoma (HCC) stem cells by reducing reactive oxygen species (ROS) levels. Hence, it has been proposed that APN/CD13 inhibition… read more here.
Keywords: antitumor effect; peg plys; apn cd13; stem cells ... See more keywords
Molecular hydrogen as a potential mediator of the antitumor effect of inulin consumption
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-96346-3
Abstract: Inulin consumption and dihydrogen (H2) administration both exert antitumor effects on preclinical models as well as in clinical trials. As H2 is one of the major byproducts of inulin fermentation by bacterial species of the… read more here.
Keywords: inulin consumption; antitumor effect; h2t; hydrogen ... See more keywords
Platelet-derived microparticles adoptively transfer integrin β3 to promote antitumor effect of tumor-infiltrating T cells
Sign Up to like & getrecommendations! Published in 2024 at "Oncoimmunology"
DOI: 10.1080/2162402x.2024.2304963
Abstract: ABSTRACT Approximately two-thirds of hepatocellular carcinoma (HCC) is considered a “cold tumor” characterized by few tumor-infiltrating T cells and an abundance of immunosuppressive cells. Cilengitide, an integrin αvβ3 inhibitor, has failed in clinical trials as… read more here.
Keywords: tumor infiltrating; infiltrating cells; hcc; tumor ... See more keywords