WWP2 overexpression inhibits the antitumor effects of doxorubicin in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11856
Abstract: Hepatocellular carcinoma (HCC) is a common liver cancer that accounts for 90% of cases. Doxorubicin exhibits a broad spectrum of antitumor activity and is one of the most active agents in HCC. WW domain‐containing protein… read more here.
Keywords: wwp2 overexpression; hepatocellular carcinoma; effects doxorubicin; wwp2 ... See more keywords
Synergistic antitumor effects of rhein and doxorubicin in hepatocellular carcinoma cells.
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DOI: 10.1002/jcb.27514
Abstract: The aim of this study was to investigate the synergistic antitumor activity of rhein and doxorubicin (DOX) and to elucidate the underlying mechanisms in hepatocellular SMMC-7721 and HepG2 cells. Cell growth curves, caspase-3 activity, and… read more here.
Keywords: hepatocellular carcinoma; synergistic antitumor; rhein doxorubicin; antitumor effects ... See more keywords
Inhibition of FAM83D displays antitumor effects in glioblastoma via down‐regulation of the AKT/Wnt/β‐catenin pathway
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23488
Abstract: Up‐regulation of family with sequence similarity 83 member D (FAM83D) has been acknowledged as a vital contributor for the carcinogenesis of numerous cancers. The relevance of FAM83D in glioblastoma (GBM), however, is not well understood.… read more here.
Keywords: wnt catenin; catenin; catenin pathway; antitumor effects ... See more keywords
Antitumor effects of ivermectin at clinically feasible concentrations support its clinical development as a repositioned cancer drug
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-020-04041-z
Abstract: Purpose Ivermectin is an antiparasitic drug that exhibits antitumor effects in preclinical studies, and as such is currently being repositioned for cancer treatment. However, divergences exist regarding its employed doses in preclinical works. Therefore, the… read more here.
Keywords: antitumor effects; drug; cancer; repositioned cancer ... See more keywords
Antitumor effects of targeted killing of tumor-associated macrophages under photothermal conditions
Sign Up to like & getrecommendations! Published in 2021 at "Lasers in Medical Science"
DOI: 10.1007/s10103-021-03248-7
Abstract: Immunotherapy of tumors has become a research hotspot. Tumor-associated macrophages (TAMs) are the most abundant interstitial cells in a tumor’s microenvironment. As the concentration of the prepared nanoparticles increased, so their cytotoxicity of intensified. Under… read more here.
Keywords: tumor associated; antitumor effects; photothermal conditions; mab cd163 ... See more keywords
Modification of the Myelotoxic and Antitumor Effects of Polychemotherapy by Polysaccharides from Tussilago farfara L.
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-018-4313-5
Abstract: The experiments on C57Bl/6 mice with Lewis lung carcinoma showed that addition of Tussilago farfara L. polysaccharides to conventional cisplatin/paclitaxel polychemotherapy moderated neutropenia caused by antitumor therapy and increased its efficiency. The stimulating effect of… read more here.
Keywords: effects polychemotherapy; modification myelotoxic; antitumor effects; myelotoxic antitumor ... See more keywords
Mechanism Underlying Antitumor Effects of Sinomenine
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DOI: 10.1007/s11655-019-3151-2
Abstract: Sinomenine (SIN) is a bioactive alkaloid compound extracted from a Chinese medicinal plant Sinomenium acutum. It is a multitarget antitumor natural substance. Various mechanisms have been proposed for the antitumor effects of SIN, such as… read more here.
Keywords: underlying antitumor; antitumor effects; mechanism underlying; sin ... See more keywords
Tetrandrine enhances antitumor effects of the histone deacetylase inhibitor MS-275 in human cancer in a Bax- and p53-dependent manner.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173575
Abstract: MS-275 (Entinostat), is an oral histone deacetylase (HDAC) inhibitor with a high specificity for class 1 HDACs. As single agent, MS-275 exerts only modest antitumor activity against most solid malignancies. The use of MS-275 in… read more here.
Keywords: bax p53; histone deacetylase; antitumor effects; tetrandrine ... See more keywords
Assessment of behavioral changes and antitumor effects of silver nanoparticles synthesized using diosgenin in mice model
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2021.102766
Abstract: Abstract Silver nanoparticles (AgNPs) are widely accepted for their physical, chemical and biological properties which could relate to their applications in medicine. Hence, these particles of the nano-regime could be a potential contender in search… read more here.
Keywords: antitumor effects; using diosgenin; mice; synthesized using ... See more keywords
Metabolic switching in the hypoglycemic and antitumor effects of metformin on high glucose induced HepG2 cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.04.029
Abstract: HighlightsGlucose metabolic imbalance were observed in 25 mM glucose induced HepG2 cells.ASCA was used to study hypoglycemic and antitumor effects of metformin on IR‐HepG2.Five metabolites play vital roles in hypoglycemic and antitumor effects of metformin.… read more here.
Keywords: antitumor effects; induced hepg2; hypoglycemic antitumor; hepg2 cells ... See more keywords
Design and Synthesis of Triazole-Containing HDAC Inhibitors That Induce Antitumor Effects and Immune Response.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01985
Abstract: Histone deacetylase (HDAC) is an epigenetic antitumor drug target, but most existing HDAC inhibitors show limited antitumor activity and their use is often accompanied by serious adverse effects. To overcome these problems, we designed and… read more here.
Keywords: design synthesis; antitumor effects; hdac inhibitors; triazole containing ... See more keywords