Antitumor efficacy of CRISPR/Cas9–engineered ICP6 mutant herpes simplex viruses in a mouse xenograft model for lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28069
Abstract: Oncolytic viruses (OVs), including oncolytic herpes simplex viruses (oHSVs), are promising therapeutics against cancer. Here, we report two ICP6‐mutated HSVs (type I) generated by CRISPR/Cas9, rHSV1/∆RR (with ICP6 ribonucleotide reductase [RR] domain deleted) and rHSV1/∆ICP6… read more here.
Keywords: crispr cas9; antitumor; lung adenocarcinoma; antitumor efficacy ... See more keywords
PEGylated lipid microspheres loaded with cabazitaxel for intravenous administration: stability, bioavailability, antitumor efficacy, and toxicity
Sign Up to like & getrecommendations! Published in 2018 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-018-0562-0
Abstract: This paper aimed to develop a novel lipid microsphere delivering cabazitaxel (CTX) using phosphatidylcholine combined with DSPE-PEG2000 as emulsifier, and evaluate its stability, pharmacokinetics, antitumor efficacy, and toxicity. The pegylated cabazitaxel-loaded lipid microspheres (CTX-PLMs) were… read more here.
Keywords: antitumor efficacy; ctx; toxicity; ctx plms ... See more keywords
Recombinant adenovirus expressing the fusion protein PD1PVR improves CD8+ T cell-mediated antitumor efficacy with long-term tumor-specific immune surveillance in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular oncology"
DOI: 10.1007/s13402-021-00633-w
Abstract: PURPOSE Treatment-associated upregulation of suppressive checkpoints and a lack of costimulatory signals compromise the antitumor efficacy of oncolytic virus immunotherapy. Therefore, we aimed to identify highly effective therapeutic targets to provide a proof-of-principle for immune… read more here.
Keywords: hepatocellular carcinoma; antitumor efficacy; mediated antitumor; efficacy ... See more keywords
Hydroxycamptothecin nanoparticles based on poly/oligo (ethylene glycol): Architecture effects of nanocarriers on antitumor efficacy
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2018.12.003
Abstract: Graphical abstract The branched degree of nanocarriers not only affect the morphology of HCPT‐loaded nanoparticles, but also influence their antitumor efficacy. Increasing the branched degree, the antitumor efficacy could enhance significantly. Figure. No caption available.… read more here.
Keywords: antitumor efficacy; ethylene glycol; architecture; efficacy ... See more keywords
Codelivery of Epigallocatechin-3-Gallate and Diallyl Trisulfide by Near-Infrared Light-Responsive Mesoporous Polydopamine Nanoparticles for Enhanced Antitumor Efficacy.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.120020
Abstract: Green tea extract epigallocatechin-3-gallate (EGCG), as a kind of natural active compounds, has become a research hotspot in cancer treatment. However, poor stability, low bioavailability and antitumor efficacy limit the application of EGCG. In this… read more here.
Keywords: diallyl trisulfide; near infrared; antitumor efficacy; epigallocatechin gallate ... See more keywords
Immunosuppression Does Not Reduce Antitumor Efficacy.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.04.087
Abstract: I read with great interest the paper by Mahmood et al. [(1)][1]. The authors conducted a very valuable and interesting study of 35 patients with immune checkpoint inhibitor (ICI)-associated myocarditis compared with 105 ICI-treated patients without myocarditis in… read more here.
Keywords: cardiology; reduce antitumor; antitumor efficacy; immunosuppression reduce ... See more keywords
Reply: Immunosuppression Does Not Reduce Antitumor Efficacy.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.06.005
Abstract: We thank Dr. Cao for his comments on our paper [(1)][1] and for asking a critical question: Does the use of systemic immunosuppression reduce the antitumor efficacy of immune checkpoint inhibitors? There are no data on… read more here.
Keywords: immunosuppression; reduce antitumor; antitumor efficacy; immunosuppression reduce ... See more keywords
Thermosensitive Polymer Conjugated Prodrug-Activating Enzyme with Enhanced Tumor Retention and Antitumor Efficacy.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c01006
Abstract: Enzyme-activated prodrug therapy has emerged as an effective strategy for cancer therapy. However, the inefficient delivery of prodrug-activating enzymes into tumor tissues leads to unsatisfactory antitumor efficacy and undesirable toxicity to normal tissues. Herein, we… read more here.
Keywords: antitumor efficacy; tumor; thermosensitive polymer;
Discovery of 2-Methyl-2-(4-(2-methyl-8-(1H-pyrrolo[2,3-b]pyridin-6-yl)-1H-naphtho[1,2-d]imidazol-1-yl)phenyl)propanenitrile as a Novel PI3K/mTOR Inhibitor with Enhanced Antitumor Efficacy In Vitro and In Vivo.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00572
Abstract: PI3K/Akt/mTOR signaling pathway is a validated drug target for cancer treatment that plays a critical role in controlling tumor growth, proliferation, and apoptosis. However, no FDA-approved PI3K/mTOR dual inhibitor exists. Thus, a candidate with a… read more here.
Keywords: inhibitor; pi3k mtor; antitumor efficacy; mtor ... See more keywords
Toosendanin demonstrates promising antitumor efficacy in osteosarcoma by targeting STAT3
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.270
Abstract: Signal transducer and activator of transcription 3(STAT3) is an emerging target for cancer therapy. In this study, we identify Toosendanin (TSN) is an effective inhibitor of STAT3, leading to the impediment of various oncogenic processes… read more here.
Keywords: antitumor efficacy; promising antitumor; toosendanin demonstrates; efficacy osteosarcoma ... See more keywords
Copper (α)/cis-platinum-loaded nanogels as an adjuvant potentiate disulfiram's antitumor efficacy.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d1bm01795k
Abstract: Disulfiram (DSF) is nontoxic and exerts anticancer activity by forming highly toxic chelates via its metabolite diethyldithiocarbamate with transition metal ions. However, there are not enough such ions in the human body to maintain the… read more here.
Keywords: disulfiram; antitumor efficacy; copper; cis platinum ... See more keywords