Near‐Infrared Triggered Cascade of Antitumor Immune Responses Based on the Integrated Core–Shell Nanoparticle
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DOI: 10.1002/adfm.202000335
Abstract: The clinical application of antitumor immunotherapy still faces severe challenges related to efficacy. Here, a light‐triggered core–shell nanosystem is designed to boost antitumor immune response via controlled release of anti‐PD‐L1 (αPD‐L1) antibodies and enhanced antigen… read more here.
Keywords: antitumor; antitumor immune; shell; near infrared ... See more keywords
Emerging Biomaterials Imaging Antitumor Immune Response
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DOI: 10.1002/adma.202204034
Abstract: Immunotherapy is one of the most promising clinical modalities for the treatment of malignant tumors and has shown excellent therapeutic outcomes in clinical settings. However, it continues to face several challenges, including long treatment cycles,… read more here.
Keywords: imaging antitumor; emerging biomaterials; antitumor immune; immune response ... See more keywords
A Dual‐Responsive STAT3 Inhibitor Nanoprodrug Combined with Oncolytic Virus Elicits Synergistic Antitumor Immune Responses by Igniting Pyroptosis
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DOI: 10.1002/adma.202209379
Abstract: Immune checkpoint blockade (ICB) therapy shows excellent efficacy against malignancies; however, insufficient tumor immunogenicity and the immunosuppressive tumor microenvironment (TME) are considered as the two major stumbling blocks to a broad ICB response. Here, a… read more here.
Keywords: antitumor immune; pyroptosis; combined oncolytic; dual responsive ... See more keywords
Enhanced Antitumor Immune Responses via a Self-Assembled Carrier-Free Nanovaccine.
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DOI: 10.1021/acs.nanolett.1c00648
Abstract: Nanovaccines have emerged as promising agents for cancer immunotherapy. However, insufficient antitumor immunity caused by inefficient antigen/adjuvant loading and complicated preparation processes are the major obstacles that limit their clinical application. Herein, two adjuvants, monophosphatidyl… read more here.
Keywords: immune responses; enhanced antitumor; via self; responses via ... See more keywords
DNA-Based MXFs to Enhance Radiotherapy and Stimulate Robust Antitumor Immune Responses.
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DOI: 10.1021/acs.nanolett.1c04888
Abstract: Metal "X" Frameworks (MXFs) constructed from metal ions and biomacromolecules ("X components") via coordination interactions show crystalline structures and diverse functionalities. Here, a series of MXFs composed of various metal ions (e.g., Zn2+, Hf4+, Ca2+)… read more here.
Keywords: immune responses; antitumor immune; radiotherapy; robust antitumor ... See more keywords
Melanin-Based Immunoregulatory Nanohybrids Enhance Antitumor Immune Responses in Breast Cancer Mouse Model.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.3c02287
Abstract: Natural melanin nanoparticles (MNPs) have demonstrated a potential for eliciting antitumor immune responses through inducing immunogenic cell death (ICD); however, the tumor microenvironment (TME) has been shown to inhibit T cell-mediated antitumor immunity. To address… read more here.
Keywords: immune responses; antitumor immune; melanin; melanin mnox ... See more keywords
Expression pattern of m6A regulators is significantly correlated with malignancy and antitumor immune response of breast cancer
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DOI: 10.1038/s41417-020-00208-1
Abstract: More than 24 regulators have been revealed to dynamically participant in N6-methyladenosine (m6A) RNA methylation, and play critical roles in tumorigenesis and development of cancers. However, their functional roles have not been comprehensively clarified in… read more here.
Keywords: breast cancer; m6a regulators; m6a; cancer ... See more keywords
Mobilization of innate and adaptive antitumor immune responses by the RNP-targeting antibody ATRC-101
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123483119
Abstract: Significance A target-agnostic approach that harnesses the human antitumor immune response to find potential anticancer lead antibodies and their targets was used to generate ATRC-101, an engineered version of a tumor-targeting antibody identified from a… read more here.
Keywords: atrc 101; targeting antibody; antitumor; antitumor immune ... See more keywords
Gut microbiota modulate radiotherapy-associated antitumor immune responses against hepatocellular carcinoma Via STING signaling
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DOI: 10.1080/19490976.2022.2119055
Abstract: ABSTRACT Studies of the gut–liver axis have enhanced our understanding of the pathophysiology of various liver diseases and the mechanisms underlying the regulation of the effectiveness of therapies. Radiotherapy (RT) is an important therapeutic option… read more here.
Keywords: hepatocellular carcinoma; gut microbiota; immune responses; antitumor immune ... See more keywords
Tumour angiogenesis normalized by myo‐inositol trispyrophosphate alleviates hypoxia in the microenvironment and promotes antitumor immune response
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DOI: 10.1111/jcmm.16399
Abstract: Pathologic angiogenesis directly responds to tumour hypoxia and controls the molecular/cellular composition of the tumour microenvironment, increasing both immune tolerance and stromal cooperation with tumour growth. Myo‐inositol‐trispyrophosphate (ITPP) provides a means to achieve stable normalization… read more here.
Keywords: myo inositol; microenvironment; angiogenesis; inositol trispyrophosphate ... See more keywords
Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses
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DOI: 10.1126/scitranslmed.aax6337
Abstract: Innate defense regulator RP-182 targets CD206high M2-like macrophages in malignant and noncancerous diseases. Spinning ancient peptides into gold Tumors co-opt macrophages to promote tumor growth and evasion from immune surveillance. Through biophysical homology screening, Jaynes… read more here.
Keywords: tumor; tumor associated; cancer; associated macrophages ... See more keywords