A Photosensitizer Discretely Loaded Nanoaggregate with Robust Photodynamic Effect for Local Treatment Triggers Systemic Antitumor Responses.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.1c10590
Abstract: Photodynamic therapy (PDT), is a rising star for suppression of in situ and metastatic tumors, yet it is impeded by low ROS production and off-target phototoxicity. Herein, an aggregation degree editing strategy, inspired by gene… read more here.
Keywords: antitumor responses; discretely loaded; icg; systemic antitumor ... See more keywords
Metabolic reprogramming of natural killer cells in obesity limits antitumor responses
Sign Up to like & getrecommendations! Published in 2018 at "Nature Immunology"
DOI: 10.1038/s41590-018-0251-7
Abstract: Up to 49% of certain types of cancer are attributed to obesity, and potential mechanisms include overproduction of hormones, adipokines, and insulin. Cytotoxic immune cells, including natural killer (NK) cells and CD8+ T cells, are… read more here.
Keywords: ppar; natural killer; antitumor responses; obesity ... See more keywords
Dynamic control of tumor vasculature improves antitumor responses in a regional model of melanoma
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DOI: 10.1038/s41598-020-70233-5
Abstract: Despite advances in therapy for melanoma, heterogeneous responses with limited durability represent a major gap in treatment outcomes. The purpose of this study was to determine whether alteration in tumor blood flow could augment drug… read more here.
Keywords: dynamic control; control; regional model; antitumor responses ... See more keywords
A2AR Antagonism with CPI-444 Induces Antitumor Responses and Augments Efficacy to Anti–PD-(L)1 and Anti–CTLA-4 in Preclinical Models
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-18-0056
Abstract: Adenosine signaling in tumors can lead to suppression of antitumor responses. A new adenosine receptor antagonist, CPI-444, neutralized this suppression, resulting in tumor regression and immune memory, and when combined with immune checkpoint blockade, further… read more here.
Keywords: anti ctla; anti anti; cpi; antitumor responses ... See more keywords
Endothelial cells express NKG2D ligands and desensitize antitumor NK responses
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DOI: 10.7554/elife.30881
Abstract: Natural Killer (NK) cells confer protection from tumors and infections by releasing cytotoxic granules and pro-inflammatory cytokines upon recognition of diseased cells. The responsiveness of NK cells to acute stimulation is dynamically tuned by steady-state… read more here.
Keywords: express nkg2d; ligands desensitize; nkg2d ligands; antitumor responses ... See more keywords