Synthesis and antitumoral evaluation of natural product‐like compounds based on tropolone and benzotropolone derivatives
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200305
Abstract: We present the preparation of a series of novel natural product‐like homobarrelenones, norcaranes, and dihydrofluorenones through a diversity‐oriented synthetic (DOS) strategy that combines Diels–Alder reactions and phototransformations, as well as their biological evaluation against MCF‐7,… read more here.
Keywords: natural product; antitumoral evaluation; synthesis antitumoral; product like ... See more keywords
Structure-based design, synthesis and antitumoral evaluation of enulosides.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.01.036
Abstract: Enulosides, carbohydrate derivatives containing an α,β-unsaturated carbonyl unit, were designed and obtained in high yields and isomeric purity. All synthesized compounds exhibited antitumoral activity in micromolar range against four tested tumor cells lines, being the… read more here.
Keywords: design synthesis; antitumoral evaluation; synthesis antitumoral; evaluation enulosides ... See more keywords