Differential procoagulant effects of saw-scaled viper (Serpentes: Viperidae: Echis) snake venoms on human plasma and the narrow taxonomic ranges of antivenom efficacies.
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2017.08.020
Abstract: Saw-scaled vipers (genus Echis) are one of the leading causes of snakebite morbidity and mortality in parts of Sub-Saharan Africa, the Middle East, and vast regions of Asia, constituting a public health burden exceeding that… read more here.
Keywords: cross reactivity; human plasma; narrow taxonomic; antivenom ... See more keywords
Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites
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DOI: 10.1038/s41586-025-09661-0
Abstract: Each year, snakebite envenoming claims thousands of lives and causes severe injury to victims across sub-Saharan Africa, many of whom depend on antivenoms derived from animal plasma as their sole treatment option1. Traditional antivenoms are… read more here.
Keywords: venom induced; nanobody based; based recombinant; antivenom ... See more keywords
Effect of Agkistrodon halys antivenom in patients bit by green pit viper and the prognostic role of the disease – a retrospective cohort study
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DOI: 10.1080/15563650.2022.2041200
Abstract: Abstract Background and aims In Mainland China and Hong Kong, health authorities utilize Agkistrodon halys antivenom in the treatment of patients who sustained bites from green pit vipers. However, the treatment benefit of Agkistrodon halys… read more here.
Keywords: agkistrodon halys; antivenom; halys antivenom; green pit ... See more keywords
Late hemotoxicity following North American rattlesnake envenomation treated with crotalidae immune F(ab’)2 (equine) antivenom and crotalidae immune polyvalent Fab (ovine) antivenom reported to the North American Snakebite Sub-registry
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Toxicology"
DOI: 10.1080/15563650.2022.2042550
Abstract: Abstract Introduction Late hemotoxicity is common following rattlesnake envenomation treated with crotalidae immune polyvalent Fab (ovine) (FabAV). Initial clinical trials showed crotalidae immune F(ab')2 (equine) (Fab2AV) to be superior to FabAV in preventing late hemotoxicity,… read more here.
Keywords: envenomation; hemotoxicity; late hemotoxicity; crotalidae immune ... See more keywords
Characterization of hypofibrinogenemia following rattlesnake envenomation treated with crotalidae immune F(ab’)2 (equine) antivenom
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Toxicology"
DOI: 10.1080/15563650.2024.2406427
Abstract: Abstract Introduction Hemotoxicity is common following rattlesnake envenomation. Published experiences with equine-derived crotalidae immune F(ab’)2 antivenom have characterized hemotoxicity as delayed, recurrent, or persistent. This study investigated recovery of hypofibrinogenemia following rattlesnake envenomation treated with… read more here.
Keywords: rattlesnake; rattlesnake envenomation; recovery; antivenom ... See more keywords
Efficacy of specific antivenom and fresh frozen plasma in reversing Daboia palaestinae venom-induced hemostatic derangement.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of veterinary emergency and critical care"
DOI: 10.1111/vec.12978
Abstract: OBJECTIVES To evaluate the in vitro efficacy of specific Daboia (Vipera) palaestinae (Dp) antivenom or fresh frozen plasma (FFP) against Dp venom-induced hemostatic changes DESIGN: In vitro study. SETTING Laboratory of a university referral hospital.… read more here.
Keywords: efficacy specific; antivenom; venom induced; specific antivenom ... See more keywords
A Bayesian phase 2 model based adaptive design to optimise antivenom dosing: Application to a dose-finding trial for a novel Russell’s viper antivenom in Myanmar
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0008109
Abstract: For most antivenoms there is little information from clinical studies to infer the relationship between dose and efficacy or dose and toxicity. Antivenom dose-finding studies usually recruit too few patients (e.g. fewer than 20) relative… read more here.
Keywords: model based; dose finding; based adaptive; antivenom ... See more keywords
Potential economic and clinical implications of improving access to snake antivenom in five ASEAN countries: A cost-effectiveness analysis
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DOI: 10.1371/journal.pntd.0010915
Abstract: Background Despite domestic production of antivenoms in the Association of Southeast Asian Nations (ASEAN) countries, not all victims with snakebite envenomings indicated for antivenom received the appropriate or adequate effective dose of antivenom due to… read more here.
Keywords: asean countries; improving access; antivenom; access ... See more keywords
Evaluating Antivenom Efficacy against Echis carinatus Venoms—Screening for In Vitro Alternatives
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DOI: 10.3390/toxins14070481
Abstract: In India, polyvalent antivenom is the mainstay treatment for snakebite envenoming. Due to batch-to-batch variation in antivenom production, manufacturers have to estimate its efficacy at each stage of IgG purification using the median effective dose… read more here.
Keywords: venom; antivenom efficacy; echis carinatus; efficacy ... See more keywords
In Vitro Toxicity of Chinese Russell’s Viper (Daboia siamensis) Venom and Neutralisation by Antivenoms
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DOI: 10.3390/toxins14070505
Abstract: Daboia siamensis (Russell’s viper) is a highly venomous and medically important snake in China, as well as much of Asia. There is minimal information on the pharmacological activity of the venom of the Chinese species,… read more here.
Keywords: siamensis; venom; russell viper; antivenom ... See more keywords
Proteomic Analysis, Immuno-Specificity and Neutralization Efficacy of Pakistani Viper Antivenom (PVAV), a Bivalent Anti-Viperid Antivenom Produced in Pakistan
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DOI: 10.3390/toxins15040265
Abstract: Snakebite envenoming is a neglected tropical disease prevalent in South Asia. In Pakistan, antivenoms are commonly imported from India despite the controversy over their effectiveness. To solve the problem, the locals have developed the Pakistani… read more here.
Keywords: viper antivenom; neutralization; pakistani viper; antivenom pvav ... See more keywords