Metal Complexes as Antiviral Agents for SARS‐CoV‐2
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DOI: 10.1002/cbic.202100186
Abstract: The severe acute respiratory syndrome – coronavirus 2 (SARS‐CoV‐2), the infectious agent responsible for COVID‐19 – has caused more than 2.5 million deaths worldwide and triggered a global pandemic. Even with successful vaccines being delivered,… read more here.
Keywords: agents sars; complexes antiviral; metal complexes; antiviral agents ... See more keywords
Screening and identification of 3‐aryl‐quinolin‐2‐one derivatives as antiviral agents against influenza A
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28327
Abstract: Quinolin‐2‐one represents an important and valuable chemical motif that possesses a wide variety of biological activities; however, the anti‐influenza activities of quinolin‐2‐one‐containing compounds were rarely reported. Herein, we describe the screening and identification of 3‐aryl‐quinolin‐2‐one… read more here.
Keywords: identification aryl; aryl quinolin; quinolin one; antiviral agents ... See more keywords
Medicinal chemistry strategies toward host targeting antiviral agents
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DOI: 10.1002/med.21664
Abstract: Abstract Direct‐acting antiviral agents (DAAs) represent a class of drugs targeting viral proteins and have been demonstrated to be very successful in combating viral infections in clinic. However, DAAs suffer from several inherent limitations, including… read more here.
Keywords: medicinal chemistry; chemistry; viral infections; antiviral agents ... See more keywords
Nucleoside analogs as potential antiviral agents for dengue virus infections
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DOI: 10.1007/s00044-017-1863-4
Abstract: Dengue virus is the causative agent of dengue fever and also the most prevalent mosquito borne viral pathogen. Up until now, treatments for dengue fever rely mainly on intensive supportive therapies. This study aimed to… read more here.
Keywords: dengue virus; analogs potential; potential antiviral; nucleoside analogs ... See more keywords
COVID-19: Antiviral Agents, Antibody Development and Traditional Chinese Medicine
Sign Up to like & getrecommendations! Published in 2020 at "Virologica Sinica"
DOI: 10.1007/s12250-020-00297-0
Abstract: The World Health Organization (WHO) has declared coronavirus disease 2019 (COVID-19) is the first pandemic caused by coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, there is no effective anti-SARS-CoV-2 drug approved worldwide… read more here.
Keywords: medicine; traditional chinese; antiviral agents; antibody development ... See more keywords
Hepatocellular metastasis recurrence in liver transplant after treatment with direct antiviral agents
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Journal of Gastroenterology"
DOI: 10.1007/s12328-019-01031-4
Abstract: Chronic HCV liver infection is considered one of the main causes of liver cirrhosis and hepatocellular carcinoma (HCC). For a selected group of patients, orthotopic liver transplantation (OLTx) is the most effective option to cure… read more here.
Keywords: recurrence; direct antiviral; treatment; liver ... See more keywords
Changing Urban-Rural Disparities in the Utilization of Direct-Acting Antiviral Agents for Hepatitis C in U.S. Medicare Patients, 2014-2017.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of preventive medicine"
DOI: 10.1016/j.amepre.2020.08.031
Abstract: INTRODUCTION The advent of direct-acting antiviral agents for treating hepatitis C virus infection has made hepatitis C virus elimination possible. Rural patients with hepatitis C virus infection may be less likely to access direct-acting antiviral… read more here.
Keywords: direct acting; urban rural; acting antiviral; antiviral agents ... See more keywords
Development of antibody-based assays for high throughput discovery and mechanistic study of antiviral agents against yellow fever virus
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DOI: 10.1016/j.antiviral.2020.104907
Abstract: Abstract Despite the availability of a highly effective yellow fever virus (YFV) vaccine, outbreaks of yellow fever frequently occur in Africa and South America with significant mortality, highlighting the pressing need for antiviral drugs to… read more here.
Keywords: yellow fever; rna; antiviral agents; throughput discovery ... See more keywords
'REAL-LIFE' EXPERIENCE WITH DIRECT-ACTING ANTIVIRAL AGENTS FOR HCV AFTER KIDNEY TRANSPLANT.
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DOI: 10.1016/j.aohep.2021.100337
Abstract: INTRODUCTIONS AND OBJECTIVES The introduction of direct-acting antiviral agents promises to change dramatically the management of hepatitis C in kidney transplant recipients, a patient group where the treatment of hepatitis C was historically challenging. The… read more here.
Keywords: kidney transplant; direct acting; acting antiviral; antiviral agents ... See more keywords
Effect of Direct Antiviral Agents on Atherosclerosis in Patients with Chronic Hepatitis C.
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DOI: 10.1016/j.arcmed.2021.04.009
Abstract: BACKGROUND Chronic hepatitis C is an independent risk factor for atherosclerosis and is associated with cardiovascular events. Mechanisms include inflammatory cytokines, endothelial dysfunction, and increased oxidative stress. AIM OF THE STUDY The objective was to… read more here.
Keywords: direct antiviral; antiviral agents; patients chronic; chronic hepatitis ... See more keywords
Expanding the activity spectrum of antiviral agents.
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DOI: 10.1016/j.drudis.2019.04.006
Abstract: Broad-spectrum antivirals (BSAs) are agents that inhibit replication of several human viruses. Here, we review 108 approved, investigational, and experimental BSAs, for which safety profiles in humans are available. The most effective and tolerable BSAs… read more here.
Keywords: expanding activity; activity spectrum; antiviral agents; spectrum antiviral ... See more keywords