Roles of SAMHD1 in antiviral defense, autoimmunity and cancer
Sign Up to like & getrecommendations! Published in 2017 at "Reviews in Medical Virology"
DOI: 10.1002/rmv.1931
Abstract: The enzyme, sterile α motif and histidine‐aspartic acid domain–containing protein 1 (SAMHD1) diminishes infection of human immunodeficiency virus type 1 (HIV‐1) by hydrolyzing intracellular deoxynucleotide triphosphates (dNTPs) in myeloid cells and resting CD4+ T cells.… read more here.
Keywords: samhd1 antiviral; hiv; antiviral defense; samhd1 ... See more keywords
A Requirement for Argonaute 4 in Mammalian Antiviral Defense
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.021
Abstract: SUMMARY While interferon (IFN) responses are critical for mammalian antiviral defense, induction of antiviral RNA interference (RNAi) is evident. To date, individual functions of the mammalian RNAi and micro RNA (miRNA) effector proteins Argonautes 1–4… read more here.
Keywords: mammalian antiviral; ifn; rnai; antiviral defense ... See more keywords
Selective Autophagy Receptors in Antiviral Defense.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in microbiology"
DOI: 10.1016/j.tim.2021.02.006
Abstract: Autophagy ensures the degradation of cytosolic substrates by the lysosomal pathway. Cargoes destined to be eliminated are confined within double-membrane vesicles called autophagosomes, prior to fusion with endolysosomal vacuoles. Autophagy receptors selectively interact with cargoes… read more here.
Keywords: selective autophagy; antiviral defense; autophagy; autophagy receptors ... See more keywords
Myricetin inhibits pseudorabies virus infection through direct inactivation and activating host antiviral defense
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.985108
Abstract: Myricetin, a polyhydroxyflavone compound, is one of the main ingredients of various human foods and therefore also known as dietary flavonoids. Due to the continuous emergence of resistant strains of herpesviruses, novel control measures are… read more here.
Keywords: host antiviral; myricetin; infection; pseudorabies virus ... See more keywords
Functions and evolution of FAM111 serine proteases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.1081166
Abstract: Proteolysis plays fundamental and regulatory roles in diverse cellular processes. The serine protease FAM111A (FAM111 trypsin-like peptidase A) emerged recently as a protease involved in two seemingly distinct processes: DNA replication and antiviral defense. FAM111A… read more here.
Keywords: dna; antiviral defense; fam111a; evolution fam111 ... See more keywords