ANTIVIRAL DRUG TRIAZAVIRIN, SELECTIVELY LABELED WITH 2 H, 13 C, AND 15 N STABLE ISOTOPES. SYNTHESIS AND PROPERTIES
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DOI: 10.1007/6080
Abstract: Isotope-labeled antiviral drug Triazavirin containing 2H, 13C, and 15N atoms in its structure has been synthesized. 13C2H3I and KS13CN served as donors of 13C isotopes. The use of 13С-MeI containing 2H atoms made it possible… read more here.
Keywords: antiviral drug; drug triazavirin; labeled stable; triazavirin selectively ... See more keywords
Antiviral Drug Ivermectin at Nanomolar Concentrations Inhibits Glycine-Induced Chloride Current in Rat Hippocampal Neurons
Sign Up to like & getrecommendations! Published in 2021 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-021-05125-3
Abstract: Ivermectin (IVM) belongs to the class of macrocyclic lactones, which is used as an antiparasitic agent. At present, the researchers focus on possibility to use IVM in treatment of certain forms of cancer and viral… read more here.
Keywords: concentrations inhibits; drug ivermectin; antiviral drug; ivermectin nanomolar ... See more keywords
Antiviral drug screening by assessing epithelial functions and innate immune responses in human 3D airway epithelium model
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2018.06.007
Abstract: ABSTRACT Respiratory viral infections cause mild to severe diseases, such as common cold, bronchiolitis and pneumonia and are associated with substantial burden for society. To test new molecules for shortening, alleviating the diseases or to… read more here.
Keywords: epithelial functions; antiviral drug; antiviral drugs; mucociliary clearance ... See more keywords
Cellular Signaling Analysis shows antiviral, ribavirin-mediated ribosomal signaling modulation
Sign Up to like & getrecommendations! Published in 2019 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2019.104598
Abstract: Abstract As antiviral drug resistance develops and new viruses emerge there is a pressing need to develop strategies to rapidly develop antiviral therapeutics. Here we use phospho-specific flow cytometry to assess perturbations of many different… read more here.
Keywords: ribavirin; antiviral drug; cellular signaling; drug ... See more keywords
4'-Modified Nucleosides for Antiviral Drug Discovery: Achievements and Perspectives.
Sign Up to like & getrecommendations! Published in 2022 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.1c00697
Abstract: ConspectusModified nucleosides show therapeutic promise for antiviral therapies. However, issues including the emergence of drug resistance, toxicity, and coinfections have posed new challenges for nucleoside-based antiviral drug discovery, particularly in the era of the coronavirus… read more here.
Keywords: drug discovery; antiviral drug; modified nucleosides; drug ... See more keywords
Smart Organic-Inorganic Polyoxomolybdates in Forward Osmosis for Antiviral-Drug Wastewater Treatment and Drug Reclamation.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental science & technology"
DOI: 10.1021/acs.est.3c00084
Abstract: The demand to effectively treat medical wastewater has escalated with the much greater use of antiviral drugs since the COVID-19 pandemic. Forward osmosis (FO) has great potential in wastewater treatment only when appropriate draw solutes… read more here.
Keywords: wastewater; wastewater treatment; antiviral drug; drug ... See more keywords
Corrigendum: The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep46772
Abstract: Scientific Reports 7: Article number: 40920; published online 18 January 2017; updated on 24 April 2017 The Competing Financial Interests section in this Article is incorrect and should read: “Dr. Karin Bruning is a member… read more here.
Keywords: antiviral drug; sofosbuvir inhibits; clinically approved; drug sofosbuvir ... See more keywords
A multi-spectroscopic and molecular docking approach to investigate the interaction of antiviral drug oseltamivir with ct-DNA
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DOI: 10.1080/15257770.2017.1287379
Abstract: ABSTRACT The possible interaction between the antiviral drug oseltamivir and calf thymus DNA at physiological pH was studied by spectrophotometry, competitive spectrofluorimetry, differential pulse voltammogram (DPV), circular dichroism spectroscopy (CD), viscosity measurements, salt effect, and… read more here.
Keywords: drug oseltamivir; interaction antiviral; antiviral drug; dna ... See more keywords
Broad-spectrum coronavirus antiviral drug discovery
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DOI: 10.1080/17460441.2019.1581171
Abstract: ABSTRACT Introduction: The highly pathogenic coronaviruses severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are lethal zoonotic viruses that have emerged into human populations these past 15 years. These coronaviruses… read more here.
Keywords: drug discovery; highly pathogenic; coronavirus; antiviral drug ... See more keywords
An Antiviral Drug-Peramivir: Degradation and Identification of Impurities and the Endorsement of HPLC-MS Method.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of AOAC International"
DOI: 10.1093/jaoacint/qsad046
Abstract: BACKGROUND Peramivir, a neuraminidase inhibitor that serves as a transition-state analogue for influenza, inhibiting the formation of new viruses in infected cells and also been approved for intravenous administration. OBJECTIVE To validate the HPLC method… read more here.
Keywords: peramivir; hplc method; analysis; antiviral drug ... See more keywords
Cytomegalovirus DNAemia Requiring (Val)Ganciclovir Treatment for More Than 8 Weeks Is a Key Factor in the Development of Antiviral Drug Resistance
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DOI: 10.1093/ofid/ofad018
Abstract: Abstract Background Prolonged (val)ganciclovir [(V)GCV] exposure for ≥6 weeks is a known predisposing factor for cytomegalovirus (CMV) drug resistance. However, the selection of this threshold was based on limited data. In this study, we sought… read more here.
Keywords: factor; antiviral drug; resistance; treatment weeks ... See more keywords