Comparative Antiviral Efficacy of Viral Protease Inhibitors against the Novel SARS-CoV-2 In Vitro
Sign Up to like & getrecommendations! Published in 2020 at "Virologica Sinica"
DOI: 10.1007/s12250-020-00288-1
Abstract: The recent outbreak of novel coronavirus pneumonia (COVID-19) caused by a new coronavirus has posed a great threat to public health. Identifying safe and effective antivirals is of urgent demand to cure the huge number… read more here.
Keywords: viral protease; lopinavir ritonavir; antiviral efficacy; protease inhibitors ... See more keywords
Strategic Design and Optimization of Umifenovir Analogues: Balancing Antiviral Efficacy and hERG Toxicity against SARS-CoV-2.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c03093
Abstract: Arbidol (ARB, Umifenovir), a broad-spectrum antiviral from Russia, lacks Food and Drug Administration (FDA) approval due to insufficient clinical data and undocumented toxicity concerns. Its indole scaffold, with six unique substitutions, enables optimization for improved… read more here.
Keywords: sars cov; antiviral efficacy; toxicity; herg toxicity ... See more keywords
Emerging drugs for hepatitis D.
Sign Up to like & getrecommendations! Published in 2023 at "Expert opinion on emerging drugs"
DOI: 10.1080/14728214.2023.2205639
Abstract: INTRODUCTION Chronic hepatitis delta (CHD) is the most severe form of chronic viral hepatitis. Until recently, its treatment consisted of pegylated interferon alfa (pegIFN) use. AREAS COVERED Current and new drugs for treating CHD. Virus… read more here.
Keywords: antiviral efficacy; emerging drugs; hepatitis; treatment ... See more keywords
Cloning and codon optimization of a novel feline interferon omega gene for production by Pichia pastoris and its antiviral efficacy in polyethylene glycol-modified form
Sign Up to like & getrecommendations! Published in 2022 at "Virulence"
DOI: 10.1080/21505594.2022.2029330
Abstract: ABSTRACT Feline viral diseases, such as feline panleukopenia, feline infectious peritonitis, and feline coronaviral enteritis, seriously endanger the health of cats, and restrict the development of pet industry. Meanwhile, there is a current lack of… read more here.
Keywords: antiviral efficacy; pichia pastoris; codon optimization; polyethylene glycol ... See more keywords
Antiviral Efficacy and Safety of Molnupiravir Against Omicron Variant Infection: A Randomized Controlled Clinical Trial
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.939573
Abstract: Background: The rapid worldwide spread of the Omicron variant of SARS-CoV-2 has unleashed a new wave of COVID-19 outbreaks. The efficacy of molnupiravir, an approved drug, is still unknown in patients infected with the Omicron… read more here.
Keywords: antiviral efficacy; omicron variant; safety; molnupiravir ... See more keywords
In Silico Assessment of Chemical Disinfectants on Surface Proteins Unveiled Dissimilarity in Antiviral Efficacy and Suitability towards Pathogenic Viruses
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25116009
Abstract: Viral pathogens pose a substantial threat to public health and necessitate the development of effective remediation and antiviral strategies. This short communication aimed to investigate the antiviral efficacy of disinfectants on the surface proteins of… read more here.
Keywords: antiviral efficacy; chemical disinfectants; pathogenic viruses; efficacy ... See more keywords
Antiviral Efficacy of Coridothymus capitatus Essential Oil Against HSV-1 and HSV-2
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DOI: 10.3390/life14081023
Abstract: Coridothymus capitatus is a perennial herb with aromatic leaves and flowers, distinct from Thymus vulgaris in its chemical composition, resulting in a unique Thymus Essential Oil (TEO). A main component of TEO, carvacrol, is known… read more here.
Keywords: antiviral efficacy; teo; hsv; essential oil ... See more keywords
Antiviral Efficacy of Molnupiravir for COVID-19 Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14040763
Abstract: The ongoing global pandemic of COVID-19 poses unprecedented public health risks for governments and societies around the world, which have been exacerbated by the emergence of SARS-CoV-2 variants. Pharmaceutical interventions with high antiviral efficacy are… read more here.
Keywords: efficacy; antiviral efficacy; efficacy molnupiravir; molnupiravir covid ... See more keywords