Synthesis and Antiviral Evaluation of 3′‐Fluoro‐4′‐modified‐5′‐norcarbocyclic Nucleoside Phosphonates
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DOI: 10.1002/cmdc.201800804
Abstract: The synthesis and anti‐HIV evaluation of hitherto unknown 3′‐fluoro‐5′‐norcarbocyclic nucleoside phosphonates bearing adenine with modifications at the 4′ position (ethynyl, vinyl, ethyl, hydroxymethyl) is described. One of the synthesized compounds was found to be an… read more here.
Keywords: norcarbocyclic nucleoside; nucleoside phosphonates; antiviral evaluation; evaluation fluoro ... See more keywords
A PCR amplicon-based SARS-CoV-2 replicon for antiviral evaluation
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DOI: 10.1038/s41598-021-82055-0
Abstract: The development of specific antiviral compounds to SARS-CoV-2 is an urgent task. One of the obstacles for the antiviral development is the requirement of biocontainment because infectious SARS-CoV-2 must be handled in a biosafety level-3… read more here.
Keywords: rna; based sars; antiviral evaluation; sars cov ... See more keywords