MEK/ERK MAP kinase limits poly I:C-induced antiviral gene expression in RAW264.7 macrophages by reducing interferon-beta expression.
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DOI: 10.1002/1873-3468.14200
Abstract: Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA (or the synthetic dsRNA analog poly I:C) and induces a signal transduction pathway that results in activation of transcription factors that induce expression of antiviral genes including… read more here.
Keywords: mek erk; antiviral gene; interferon; gene expression ... See more keywords