FBXO6 regulates the antiviral immune responses via mediating alveolar macrophages survival
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28203
Abstract: Inducing early apoptosis in alveolar macrophages is one of the strategies influenza A virus (IAV) evolved to subvert host immunity. Correspondingly, the host mitochondrial protein nucleotide‐binding oligomerization domain‐like receptor (NLR)X1 is reported to interact with… read more here.
Keywords: regulates antiviral; immune responses; degradation nlrx1; fbxo6 regulates ... See more keywords
Immunoregulation of Theiler’s virus-induced demyelinating disease by glatiramer acetate without suppression of antiviral immune responses
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Virology"
DOI: 10.1007/s00705-018-3729-6
Abstract: While most disease-modifying drugs (DMDs) regulate multiple sclerosis (MS) by suppressing inflammation, they can potentially suppress antiviral immunity, causing progressive multifocal leukoencephalopathy (PML). The DMD glatiramer acetate (GA) has been used for MS patients who… read more here.
Keywords: antiviral immune; immune responses; glatiramer acetate; disease ... See more keywords
Antiviral Immune Response as a Trigger of FUS Proteinopathy in Amyotrophic Lateral Sclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Cell Reports"
DOI: 10.1016/j.celrep.2019.11.094
Abstract: Summary Mutations in the FUS gene cause familial amyotrophic lateral sclerosis (ALS-FUS). In ALS-FUS, FUS-positive inclusions are detected in the cytoplasm of neurons and glia, a condition known as FUS proteinopathy. Mutant FUS incorporates into… read more here.
Keywords: fus; fus proteinopathy; amyotrophic lateral; immune response ... See more keywords
Long term effects of carbaryl exposure on antiviral immune responses in Xenopus laevis.
Sign Up to like & getrecommendations! Published in 2017 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2016.12.018
Abstract: Water pollutants associated with agriculture may contribute to the increased prevalence of infectious diseases caused by ranaviruses. We have established the amphibian Xenopus laevis and the ranavirus Frog Virus 3 (FV3) as a reliable experimental… read more here.
Keywords: carbaryl exposure; xenopus laevis; long term; immune responses ... See more keywords
RNA editing by ADAR1 regulates innate and antiviral immune functions in primary macrophages
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13580-0
Abstract: ADAR1-dependent A-to-I editing has recently been recognized as a key process for marking dsRNA as self, therefore, preventing innate immune activation and affecting the development and resolution of immune-mediated diseases and infections. Here, we have… read more here.
Keywords: adar1; adar1 knockdown; immune activation; innate immune ... See more keywords
Enhancing innate antiviral immune responses in rainbow trout by double stranded RNA delivered with cationic phytoglycogen nanoparticles
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-49931-2
Abstract: Innate immunity is induced when pathogen-associated molecular patterns (PAMPs) bind host pattern recognition receptors (PRRs). Polyinosinic:polycytidylic acid [poly(I:C)] is a synthetic analogue of viral dsRNA that acts as a PAMP, inducing type I interferons (IFNs)… read more here.
Keywords: phytoglycogen nanoparticles; immune responses; cationic phytoglycogen; rainbow trout ... See more keywords
Bioreducible polymer-mediated delivery of oncolytic adenovirus can attenuate antiviral immune response and concurrently enhance the induction of antitumor immune response to effectively prevent metastasis.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00200k
Abstract: Oncolytic virotherapy is a highly promising and novel treatment modality for cancer. Several clinical trials with oncolytic viruses have illustrated that the potent antitumor efficacy of these viruses may rely on the efficient induction of… read more here.
Keywords: oad; antitumor; level; immune response ... See more keywords
The protective and pathogenic roles of IL-17 in viral infections: friend or foe?
Sign Up to like & getrecommendations! Published in 2019 at "Open Biology"
DOI: 10.1098/rsob.190109
Abstract: Viral infections cause substantial human morbidity and mortality, and are a significant health burden worldwide. Following a viral infection, the host may initiate complex antiviral immune responses to antagonize viral invasion and replication. However, proinflammatory… read more here.
Keywords: antiviral immune; pathogenic roles; immune responses; viral infections ... See more keywords
Decreased antiviral immune response within the central nervous system of aged mice is associated with increased lethality of West Nile virus encephalitis
Sign Up to like & getrecommendations! Published in 2021 at "Aging Cell"
DOI: 10.1111/acel.13412
Abstract: West Nile virus (WNV) is an emerging pathogen that causes disease syndromes ranging from a mild flu‐like illness to encephalitis. While the incidence of WNV infection is fairly uniform across age groups, the risk of… read more here.
Keywords: within central; aged mice; encephalitis; nile virus ... See more keywords
Tripartite motif‐containing proteins precisely and positively affect host antiviral immune response
Sign Up to like & getrecommendations! Published in 2018 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.12669
Abstract: The tripartite motif‐containing proteins (TRIMs) comprise a large family of proteins with over 70 members in humans. Recent studies have shown that TRIMs play unexpected roles in the antiviral immune responses to infections by HIV,… read more here.
Keywords: containing proteins; tripartite motif; motif containing; host ... See more keywords
Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response
Sign Up to like & getrecommendations! Published in 2021 at "Science Advances"
DOI: 10.1126/sciadv.abc1834
Abstract: PRMT5 directly induces methylation of cGAS and inhibits cGAS-mediated antiviral immunity. Cyclic GMP-AMP synthase (cGAS) functions as an essential DNA sensor, which senses the cytoplasmic double-stranded DNA and activates the antiviral response. However, the posttranslational… read more here.
Keywords: cgas; response; mediated antiviral; cgas mediated ... See more keywords