Methyltransferase‐Like Protein 14 Attenuates Mitochondrial Antiviral Signaling Protein Expression to Negatively Regulate Antiviral Immunity via N6‐methyladenosine Modification
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Science"
DOI: 10.1002/advs.202100606
Abstract: Abstract Mitochondrial antiviral signaling (MAVS) protein is the core signaling adaptor in the RNA signaling pathway. Thus, appropriate regulation of MAVS expression is essential for antiviral immunity against RNA virus infection. However, the regulation of… read more here.
Keywords: protein; antiviral immunity; antiviral signaling; expression ... See more keywords
RNAi-mediated antiviral immunity in insects and their possible application.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in virology"
DOI: 10.1016/j.coviro.2018.10.004
Abstract: Antiviral RNA interference (RNAi) in insects is known for some time. Previously, data from the model organism Drosophila was lightly transferred to other insects. However, since more research is performed on other insects, both similarities… read more here.
Keywords: insects; antiviral immunity; mediated antiviral; rnai ... See more keywords
Antiviral immunity triggered by infection-induced host transposable elements.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in virology"
DOI: 10.1016/j.coviro.2021.12.006
Abstract: Host silencing of transposable elements (TEs) is critical to prevent genome damage and inappropriate inflammation. However, new evidence suggests that a virus-infected host may re-activate TEs and co-opt them for antiviral defense. RNA-Seq and specialized… read more here.
Keywords: transposable elements; antiviral immunity; infection; immunity triggered ... See more keywords
Bombyx mori homolog of tumor suppressor p53 is involved in apoptosis‐mediated antiviral immunity of B. mori cells infected with nucleopolyhedrovirus
Sign Up to like & getrecommendations! Published in 2018 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2018.02.009
Abstract: &NA; Apoptosis is important in antiviral immunity and affects viral multiplication and pathogenesis. Here, we showed that Bombyx mori cells transiently expressing B. mori homolog of the tumor suppressor p53 (Bm‐p53) protein underwent apoptosis accompanied… read more here.
Keywords: bombyx mori; antiviral immunity; mori homolog; p53 ... See more keywords
Genetic determinants of antiviral immunity in dipteran insects - compiling the experimental evidence.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2021.104010
Abstract: The genetic basis of antiviral immunity in dipteran insects is extensively studied in Drosophila melanogaster and advanced technologies for genetic manipulation allow a better characterization of immune responses also in non-model insect species. Especially, immunity… read more here.
Keywords: insects; dipteran insects; antiviral immunity; experimental evidence ... See more keywords
Silver Nanoparticles Impair Retinoic Acid-Inducible Gene I-Mediated Mitochondrial Antiviral Immunity by Blocking the Autophagic Flux in Lung Epithelial Cells.
Sign Up to like & getrecommendations! Published in 2018 at "ACS nano"
DOI: 10.1021/acsnano.7b06934
Abstract: Silver nanoparticles (AgNPs) are microbicidal agents which could be potentially used as an alternative to antivirals to treat human infectious diseases, especially influenza virus infections where antivirals have generally proven unsuccessful. However, concerns about the… read more here.
Keywords: antiviral immunity; lung epithelial; epithelial cells; silver nanoparticles ... See more keywords
USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS
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DOI: 10.1038/s41467-021-23219-4
Abstract: Activation of MAVS, an adaptor molecule in Rig-I-like receptor (RLR) signaling, is indispensable for antiviral immunity, yet the molecular mechanisms modulating MAVS activation are not completely understood. Ubiquitination has a central function in regulating the… read more here.
Keywords: antiviral immunity; linked polyubiquitination; k63 linked; mavs ... See more keywords
OTUD7B deubiquitinates SQSTM1/p62 and promotes IRF3 degradation to regulate antiviral immunity
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2026098
Abstract: ABSTRACT Deubiquitination plays an important role in the regulation of the crosstalk between macroautophagy/autophagy and innate immune signaling, yet its regulatory mechanisms are not fully understood. Here we identify the deubiquitinase OTUD7B as a negative… read more here.
Keywords: irf3 degradation; otud7b; sqstm1 p62; antiviral immunity ... See more keywords
Induced Immune Reaction in the Acorn Worm, Saccoglossus kowalevskii, Informs the Evolution of Antiviral Immunity
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DOI: 10.1093/molbev/msad097
Abstract: Abstract Evolutionary perspectives on the deployment of immune factors following infection have been shaped by studies on a limited number of biomedical model systems with a heavy emphasis on vertebrate species. Although their contributions to… read more here.
Keywords: saccoglossus kowalevskii; antiviral immunity; immunity; acorn worm ... See more keywords
Restoring antiviral immunity with adoptive transfer of ex-vivo generated T cells
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Hematology"
DOI: 10.1097/moh.0000000000000461
Abstract: Purpose of review Latent viruses such as cytomegalovirus (CMV), Epstein–Barr virus (EBV) and adenovirus (ADV) often reactivate in immunocompromised patients, contributing to poor clinical outcomes. A rapid reconstitution of antiviral responses via adoptive transfer of… read more here.
Keywords: transfer vivo; antiviral immunity; transfer; adoptive transfer ... See more keywords
XAF1 Protects Host against Emerging RNA Viruses by Stabilizing IRF1-Dependent Antiviral Immunity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00774-22
Abstract: Rapid and robust induction of antiviral genes is essential for the host to clear the invaded viruses. In addition to the IRF3/7-IFN-I-STAT1 signaling axis, the XAF1-IRF1 positive feedback loop synergistically or independently drives the transcription… read more here.
Keywords: irf1; host; antiviral immunity; xaf1 ... See more keywords