Methyltransferase‐Like Protein 14 Attenuates Mitochondrial Antiviral Signaling Protein Expression to Negatively Regulate Antiviral Immunity via N6‐methyladenosine Modification
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DOI: 10.1002/advs.202100606
Abstract: Abstract Mitochondrial antiviral signaling (MAVS) protein is the core signaling adaptor in the RNA signaling pathway. Thus, appropriate regulation of MAVS expression is essential for antiviral immunity against RNA virus infection. However, the regulation of… read more here.
Keywords: protein; antiviral immunity; antiviral signaling; expression ... See more keywords
API5 Phosphorylation Promotes Antiviral Immunity by Inhibiting Degradation of Cytosolic RNA Sensor RLRs
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DOI: 10.1002/advs.202505479
Abstract: Ubiquitin‐mediated selective autophagy is essential for innate immune responses against pathogens. However, the role of apoptosis inhibitor 5 (API5), in governing both ubiquitin‐mediated autophagy and antiviral immunity, are poorly defined. Here, it is found that… read more here.
Keywords: degradation; phosphorylation; antiviral immunity; cytosolic rna ... See more keywords
RNAi-mediated antiviral immunity in insects and their possible application.
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DOI: 10.1016/j.coviro.2018.10.004
Abstract: Antiviral RNA interference (RNAi) in insects is known for some time. Previously, data from the model organism Drosophila was lightly transferred to other insects. However, since more research is performed on other insects, both similarities… read more here.
Keywords: insects; antiviral immunity; mediated antiviral; rnai ... See more keywords
Antiviral immunity triggered by infection-induced host transposable elements.
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DOI: 10.1016/j.coviro.2021.12.006
Abstract: Host silencing of transposable elements (TEs) is critical to prevent genome damage and inappropriate inflammation. However, new evidence suggests that a virus-infected host may re-activate TEs and co-opt them for antiviral defense. RNA-Seq and specialized… read more here.
Keywords: transposable elements; antiviral immunity; infection; immunity triggered ... See more keywords
Bombyx mori homolog of tumor suppressor p53 is involved in apoptosis‐mediated antiviral immunity of B. mori cells infected with nucleopolyhedrovirus
Sign Up to like & getrecommendations! Published in 2018 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2018.02.009
Abstract: &NA; Apoptosis is important in antiviral immunity and affects viral multiplication and pathogenesis. Here, we showed that Bombyx mori cells transiently expressing B. mori homolog of the tumor suppressor p53 (Bm‐p53) protein underwent apoptosis accompanied… read more here.
Keywords: bombyx mori; antiviral immunity; mori homolog; p53 ... See more keywords
Genetic determinants of antiviral immunity in dipteran insects - compiling the experimental evidence.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2021.104010
Abstract: The genetic basis of antiviral immunity in dipteran insects is extensively studied in Drosophila melanogaster and advanced technologies for genetic manipulation allow a better characterization of immune responses also in non-model insect species. Especially, immunity… read more here.
Keywords: insects; dipteran insects; antiviral immunity; experimental evidence ... See more keywords
Silver Nanoparticles Impair Retinoic Acid-Inducible Gene I-Mediated Mitochondrial Antiviral Immunity by Blocking the Autophagic Flux in Lung Epithelial Cells.
Sign Up to like & getrecommendations! Published in 2018 at "ACS nano"
DOI: 10.1021/acsnano.7b06934
Abstract: Silver nanoparticles (AgNPs) are microbicidal agents which could be potentially used as an alternative to antivirals to treat human infectious diseases, especially influenza virus infections where antivirals have generally proven unsuccessful. However, concerns about the… read more here.
Keywords: antiviral immunity; lung epithelial; epithelial cells; silver nanoparticles ... See more keywords
USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS
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DOI: 10.1038/s41467-021-23219-4
Abstract: Activation of MAVS, an adaptor molecule in Rig-I-like receptor (RLR) signaling, is indispensable for antiviral immunity, yet the molecular mechanisms modulating MAVS activation are not completely understood. Ubiquitination has a central function in regulating the… read more here.
Keywords: antiviral immunity; linked polyubiquitination; k63 linked; mavs ... See more keywords
Cleavage of Bcl-2-associated athanogene by metacaspase determines plant antiviral immunity
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DOI: 10.1038/s41467-025-64021-w
Abstract: Nucleotide-binding leucine-rich repeat receptors (NLRs) function as core components of innate immunity in both plants and animals. In animals, NLR activation initiates caspase-mediated immune signaling. In contrast, plants lack caspases but instead contain metacaspases (MCAs/MCs),… read more here.
Keywords: immunity; antiviral immunity; associated athanogene; bag3 ... See more keywords
The role of aryl hydrocarbon receptor in antiviral immunity: a focus on RNA viruses
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DOI: 10.1080/1040841x.2025.2497789
Abstract: Abstract Aryl hydrocarbon receptor (AhR) is a ligand-dependent transcriptional factor that is activated by a plethora of exogenous and endogenous compounds, including environmental pollutants, drugs, and microbial metabolites. The AhR plays an important role in… read more here.
Keywords: immunity; role; antiviral immunity; hydrocarbon receptor ... See more keywords
OTUD7B deubiquitinates SQSTM1/p62 and promotes IRF3 degradation to regulate antiviral immunity
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2026098
Abstract: ABSTRACT Deubiquitination plays an important role in the regulation of the crosstalk between macroautophagy/autophagy and innate immune signaling, yet its regulatory mechanisms are not fully understood. Here we identify the deubiquitinase OTUD7B as a negative… read more here.
Keywords: irf3 degradation; otud7b; sqstm1 p62; antiviral immunity ... See more keywords