The Endoplasmic Reticulum ATP13A1 is Essential for MAVS‐Mediated Antiviral Innate Immunity
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202203831
Abstract: RIG‐I‐MAVS signaling pathway is essential for efficient innate immune response against virus infection. Though many components have been identified in RIG‐I pathway and it can be partially reconstituted in vitro, detailed mechanisms involved in cells… read more here.
Keywords: endoplasmic reticulum; antiviral innate; mediated antiviral; mavs ... See more keywords
The emerging roles of the CDK/cyclin complexes in antiviral innate immunity.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medical virology"
DOI: 10.1002/jmv.27554
Abstract: More than 20 members of the human Cyclin-dependent kinases (CDKs) family share the feature of being activated by cyclins. CDKs have been involved in diverse biological processes, such as cell cycle, transcription, DNA damage response,… read more here.
Keywords: cdk cyclin; cyclin complexes; antiviral innate; innate immunity ... See more keywords
ZNFX1 antisense RNA1 promotes antiviral innate immune responses via modulating ZNFX1 function
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28637
Abstract: Increasing evidence suggests that natural antisense transcriptional lncRNAs regulate their adjacent coding genes to mediate diverse aspects of biology. Bioinformatics analysis of the previously identified antiviral gene ZNFX1 revealed neighboring lncRNA ZFAS1 transcribed on the… read more here.
Keywords: zfas1; function; znfx1; antiviral innate ... See more keywords
The EF-Hand Protein CALML6 Suppresses Antiviral Innate Immunity by Impairing IRF3 Dimerization.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.01.030
Abstract: The transcription factor IRF3 is phosphorylated in response to viral infection, and it subsequently forms a homodimer and translocates into the nucleus to induce the transcription of genes important for antiviral immunity, such as type I… read more here.
Keywords: immunity; dimerization; antiviral innate; innate immunity ... See more keywords
The emerging roles of NOD-like receptors in antiviral innate immune signaling pathways.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.12.127
Abstract: Viral infection triggers host pattern recognition receptors (PRRs) to recognize pathogen-associated molecular patterns or danger-associated molecular patterns to initiate antiviral innate immune responses. NOD-like receptors (NLRs) are a subgroup of cytosolic PRRs. While substantial advances… read more here.
Keywords: innate; signaling pathways; antiviral innate; immune signaling ... See more keywords
DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-19941-0
Abstract: Upon sensing cytosolic DNA, the enzyme cGAS induces innate immune responses that underpin anti-microbial defenses and certain autoimmune diseases. Missense mutations of PRKDC encoding the DNA-dependent protein kinase (DNA-PK) catalytic subunit (DNA-PKcs) are associated with… read more here.
Keywords: antiviral innate; dna deficiency; cgas mediated; dna ... See more keywords
The long noncoding RNA Lnczc3h7a promotes a TRIM25-mediated RIG-I antiviral innate immune response
Sign Up to like & getrecommendations! Published in 2019 at "Nature Immunology"
DOI: 10.1038/s41590-019-0379-0
Abstract: The helicase RIG-I initiates an antiviral immune response after recognition of pathogenic RNA. TRIM25, an E3 ubiquitin ligase, mediates K63-linked ubiquitination of RIG-I, which is crucial for RIG-I downstream signaling and the antiviral innate immune… read more here.
Keywords: rig; response; rna; antiviral innate ... See more keywords
Yin Yang 1 Dynamically Regulates Antiviral Innate Immune Responses During Viral Infection
Sign Up to like & getrecommendations! Published in 2017 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000485116
Abstract: Background/Aims: Type I interferon (IFN-1) production and IFN-1 signaling play critical roles in the host antiviral innate immune responses. Although transcription factor Yin Yang 1 (YY1) has been reported to have a dual activator/repressor role… read more here.
Keywords: infection; ifn signaling; ifn production; viral infection ... See more keywords
The Role of Atypical Ubiquitin Chains in the Regulation of the Antiviral Innate Immune Response
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2019.00392
Abstract: It is well established that polyubiquitin chains, in particular those linked through K48 and K63, play a key role in the regulation of the antiviral innate immune response. However, the role of the atypical chains… read more here.
Keywords: regulation antiviral; antiviral innate; role; immune response ... See more keywords
Skin Viral Infections: Host Antiviral Innate Immunity and Viral Immune Evasion
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.593901
Abstract: The skin is an active immune organ that functions as the first and largest site of defense to the outside environment. Serving as the primary interface between host and pathogen, the skin’s early immune responses… read more here.
Keywords: host antiviral; viral infections; antiviral innate; infections host ... See more keywords
Bat Employs a Conserved MDA5 Gene to Trigger Antiviral Innate Immune Responses
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.904481
Abstract: Bats are important hosts for various zoonotic viral diseases. However, they rarely show signs of disease infection with such viruses. As the first line for virus control, the innate immune system of bats attracted our… read more here.
Keywords: mda5 gene; virus; innate immune; antiviral innate ... See more keywords