A Chemical Strategy for Intracellular Arming of an Endogenous Broad-Spectrum Antiviral Nucleotide.
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DOI: 10.1021/acs.jmedchem.1c01481
Abstract: The naturally occurring nucleotide 3'-deoxy-3',4'-didehydro-cytidine-5'-triphosphate (ddhCTP) was recently found to exert potent and broad-spectrum antiviral activity. However, nucleoside 5'-triphosphates in general are not cell-permeable, which precludes the direct use of ddhCTP as a therapeutic. To… read more here.
Keywords: chemical strategy; broad spectrum; antiviral nucleotide; spectrum antiviral ... See more keywords