A potential robust antiviral defense state in the common vampire bat: Expression, induction and molecular characterization of the three interferon‐stimulated genes ‐OAS1, ADAR1 and PKR
Sign Up to like & getrecommendations! Published in 2018 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2018.04.006
Abstract: ABSTRACT Bats are known to harbor many zoonotic viruses, some of which are pathogenic to other mammals while they seem to be harmless in bats. As the interferon (IFN) response represents the first line of… read more here.
Keywords: response; three interferon; common vampire; antiviral response ... See more keywords
Characterization, functional and signaling elucidation of pigeon (Columba livia) interferon‐&agr;: Knockdown p53 negatively modulates antiviral response
Sign Up to like & getrecommendations! Published in 2019 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2018.08.017
Abstract: ABSTRACT The regulation of interferon‐&agr; signaling pathways is essential to protect the host from infection with a broad range of viruses. However, information regarding antiviral response and the specific molecular mechanism of Columba livia interferon‐&agr;… read more here.
Keywords: agr; coifn agr; antiviral response; columba livia ... See more keywords
An antiviral response beyond immune cells
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/d41586-020-01916-2
Abstract: Fibroblast, epithelial and endothelial cells are more than just the scaffold of an organ — it emerges that they communicate with immune cells and are primed to launch organ-specific gene-expression programs for antiviral defence. Fibroblast,… read more here.
Keywords: immune cells; beyond immune; antiviral response; response beyond ... See more keywords
DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06771-4
Abstract: Oncolytic virotherapy is a promising therapeutic strategy that uses replication-competent viruses to selectively destroy malignancies. However, the therapeutic effect of certain oncolytic viruses (OVs) varies among cancer patients. Thus, it is necessary to overcome resistance… read more here.
Keywords: cancer; dna inhibition; antiviral response; dna ... See more keywords
Porcine intraepithelial lymphocytes undergo migration and produce an antiviral response following intestinal virus infection.
Sign Up to like & getrecommendations! Published in 2022 at "Communications biology"
DOI: 10.1038/s42003-022-03205-2
Abstract: The location of intraepithelial lymphocytes (IELs) between epithelial cells provide a first line of immune defense against enteric infection. It is assumed that IELs migrate only along the basement membrane or into the lateral intercellular… read more here.
Keywords: porcine; intraepithelial lymphocytes; antiviral response; infection ... See more keywords
Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2122805119
Abstract: Significance Virus-induced signal adaptor (VISA)/mitochondrial antiviral signaling protein (MAVS) is an essential adaptor protein in innate immune response to RNA viruses; understanding how VISA is regulated is important for the treatment of infectious diseases. In… read more here.
Keywords: tankyrases inhibit; response; rnf146; antiviral response ... See more keywords
DDX54 drives ALKBH5-mediated demethylation of selected transcripts to suppress interferon antiviral response
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Virology"
DOI: 10.1128/jvi.00507-25
Abstract: ABSTRACT DEAD-box (DDX) proteins are currently reported to shape host innate immunity by regulation of N6-methyladenosine (m6A) modification of transcripts for host factors involved in antiviral signaling. However, which DDX proteins are involved in antiviral… read more here.
Keywords: m6a; selected transcripts; response; interferon antiviral ... See more keywords
Lys-specific gingipain (Kgp) of P. gingivalis promotes viral infection by disabling the interferon pathway
Sign Up to like & getrecommendations! Published in 2025 at "mBio"
DOI: 10.1128/mbio.00298-25
Abstract: ABSTRACT Periodontitis (PD) is a chronic inflammatory disease of the periodontium with a high prevalence and is considered a potential risk factor for the development of other diseases. These include viral infections of the upper… read more here.
Keywords: gingipain; virus; infection; gingivalis ... See more keywords
Single stranded (ss)RNA-mediated antiviral response against infectious laryngotracheitis virus infection
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DOI: 10.1186/s12866-019-1398-6
Abstract: BackgroundSingle stranded ribonucleic acid (ssRNA) binds to toll-like receptor (TLR)7 leading to recruitment of immune cells and production of pro-inflammatory cytokines, which has been shown in mammals. In chickens, synthetic ssRNA analog, resiquimod, has been… read more here.
Keywords: response; infection; antiviral response; response infectious ... See more keywords
Antiviral response elicited against avian influenza virus infection following activation of toll-like receptor (TLR)7 signaling pathway is attributable to interleukin (IL)-1β production
Sign Up to like & getrecommendations! Published in 2018 at "BMC Research Notes"
DOI: 10.1186/s13104-018-3975-4
Abstract: ObjectiveSingle stranded ribonucleic acid (ssRNA) binds to toll-like receptor (TLR)7 leading to recruitment of immune cells and production of pro-inflammatory cytokines, which has been shown in mammals. In chickens, ssRNA has been shown to elicit… read more here.
Keywords: toll like; production; response; infection ... See more keywords
TRIM5 inhibits the replication of Senecavirus A by promoting the RIG-I-mediated type I interferon antiviral response
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DOI: 10.1186/s13567-024-01354-2
Abstract: Senecavirus A (SVA) is an emerging virus that poses a threat to swine herds worldwide. To date, the role of tripartite motif 5 (TRIM5) in the replication of viruses has not been evaluated. Here, TRIM5… read more here.
Keywords: replication; type interferon; rig; trim5 ... See more keywords