A potential robust antiviral defense state in the common vampire bat: Expression, induction and molecular characterization of the three interferon‐stimulated genes ‐OAS1, ADAR1 and PKR
Sign Up to like & getrecommendations! Published in 2018 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2018.04.006
Abstract: ABSTRACT Bats are known to harbor many zoonotic viruses, some of which are pathogenic to other mammals while they seem to be harmless in bats. As the interferon (IFN) response represents the first line of… read more here.
Keywords: response; three interferon; common vampire; antiviral response ... See more keywords
Characterization, functional and signaling elucidation of pigeon (Columba livia) interferon‐&agr;: Knockdown p53 negatively modulates antiviral response
Sign Up to like & getrecommendations! Published in 2019 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2018.08.017
Abstract: ABSTRACT The regulation of interferon‐&agr; signaling pathways is essential to protect the host from infection with a broad range of viruses. However, information regarding antiviral response and the specific molecular mechanism of Columba livia interferon‐&agr;… read more here.
Keywords: agr; coifn agr; antiviral response; columba livia ... See more keywords
An antiviral response beyond immune cells
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/d41586-020-01916-2
Abstract: Fibroblast, epithelial and endothelial cells are more than just the scaffold of an organ — it emerges that they communicate with immune cells and are primed to launch organ-specific gene-expression programs for antiviral defence. Fibroblast,… read more here.
Keywords: immune cells; beyond immune; antiviral response; response beyond ... See more keywords
DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06771-4
Abstract: Oncolytic virotherapy is a promising therapeutic strategy that uses replication-competent viruses to selectively destroy malignancies. However, the therapeutic effect of certain oncolytic viruses (OVs) varies among cancer patients. Thus, it is necessary to overcome resistance… read more here.
Keywords: cancer; dna inhibition; antiviral response; dna ... See more keywords
Porcine intraepithelial lymphocytes undergo migration and produce an antiviral response following intestinal virus infection.
Sign Up to like & getrecommendations! Published in 2022 at "Communications biology"
DOI: 10.1038/s42003-022-03205-2
Abstract: The location of intraepithelial lymphocytes (IELs) between epithelial cells provide a first line of immune defense against enteric infection. It is assumed that IELs migrate only along the basement membrane or into the lateral intercellular… read more here.
Keywords: porcine; intraepithelial lymphocytes; antiviral response; infection ... See more keywords
Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2122805119
Abstract: Significance Virus-induced signal adaptor (VISA)/mitochondrial antiviral signaling protein (MAVS) is an essential adaptor protein in innate immune response to RNA viruses; understanding how VISA is regulated is important for the treatment of infectious diseases. In… read more here.
Keywords: tankyrases inhibit; response; rnf146; antiviral response ... See more keywords
Single stranded (ss)RNA-mediated antiviral response against infectious laryngotracheitis virus infection
Sign Up to like & getrecommendations! Published in 2019 at "BMC Microbiology"
DOI: 10.1186/s12866-019-1398-6
Abstract: BackgroundSingle stranded ribonucleic acid (ssRNA) binds to toll-like receptor (TLR)7 leading to recruitment of immune cells and production of pro-inflammatory cytokines, which has been shown in mammals. In chickens, synthetic ssRNA analog, resiquimod, has been… read more here.
Keywords: response; infection; antiviral response; response infectious ... See more keywords
Antiviral response elicited against avian influenza virus infection following activation of toll-like receptor (TLR)7 signaling pathway is attributable to interleukin (IL)-1β production
Sign Up to like & getrecommendations! Published in 2018 at "BMC Research Notes"
DOI: 10.1186/s13104-018-3975-4
Abstract: ObjectiveSingle stranded ribonucleic acid (ssRNA) binds to toll-like receptor (TLR)7 leading to recruitment of immune cells and production of pro-inflammatory cytokines, which has been shown in mammals. In chickens, ssRNA has been shown to elicit… read more here.
Keywords: toll like; production; response; infection ... See more keywords
Host Antiviral Response Suppresses Ciliogenesis and Motile Ciliary Functions in the Nasal Epithelium
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DOI: 10.3389/fcell.2020.581340
Abstract: Background Respiratory viral infections are one of the main drivers of development and exacerbation for chronic airway inflammatory diseases. Increased viral susceptibility and impaired mucociliary clearance are often associated with chronic airway inflammatory diseases and… read more here.
Keywords: functions nasal; nasal epithelium; response; infection ... See more keywords
Neddylation Facilitates the Antiviral Response in Zebrafish
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01432
Abstract: Neddylation is a type of post-translational protein modifications, in which neural precursor cell expressed developmentally downregulated protein 8 (NEDD8) is covalently conjugated to the lysine residues of target substrates. The best characterized principal substrates of… read more here.
Keywords: facilitates antiviral; response; neddylation; neddylation facilitates ... See more keywords
Pseudomonas aeruginosa Modulates the Antiviral Response of Bronchial Epithelial Cells
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.00096
Abstract: Cystic fibrosis (CF) patients frequently acquire Pseudomonas aeruginosa infections that have been associated with a bad prognosis and an increased rate of pulmonary exacerbations. Respiratory viruses can cause exacerbations in chronic pulmonary diseases including COPD… read more here.
Keywords: epithelial cells; pseudomonas aeruginosa; infection; respiratory viruses ... See more keywords