Heterogeneity of Antiviral Responses in the Upper Respiratory Tract Mediates Differential Non-lytic Clearance of Influenza Viruses
Sign Up to like & getrecommendations! Published in 2020 at "Cell Reports"
DOI: 10.1016/j.celrep.2020.108103
Abstract: Influenza viruses initiate infection in the upper respiratory tract (URT), but early viral tropism and the importance of cell-type-specific antiviral responses in this tissue remain incompletely understood. By infecting transgenic lox-stop-lox reporter mice with a… read more here.
Keywords: upper respiratory; respiratory tract; influenza viruses; cell ... See more keywords
Engineering Cellular Biosensors with Customizable Antiviral Responses Targeting Hepatitis B Virus
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.100867
Abstract: Summary SynNotch receptor technology is a versatile tool that uses the regulatory notch core portion with an extracellular scFv and an intracellular transcription factor that enables to program customized input and output functions in mammalian… read more here.
Keywords: synnotch receptor; cellular biosensors; antiviral responses; engineering cellular ... See more keywords
ADAR1 entraps sinister cellular dsRNAs, thresholding antiviral responses.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in immunology"
DOI: 10.1016/j.it.2021.09.013
Abstract: ADAR1 edits adenosines to inosines in cellular double-stranded (ds)RNA, thereby preventing aberrant activation of antiviral dsRNA sensors, as well as interferon (IFN) induction in Aicardi-Goutières syndrome (AGS) encephalopathy. Recently, Nakahama et al., Tang et al.,… read more here.
Keywords: cellular dsrnas; adar1 entraps; dsrnas thresholding; entraps sinister ... See more keywords
USP13 negatively regulates antiviral responses by deubiquitinating STING
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DOI: 10.1038/ncomms15534
Abstract: STING (also known as MITA) is critical for host defence against viruses and the activity of STING is regulated by ubiquitination. However, the deubiquitination of STING is not fully understood. Here, we show that ubiquitin-specific… read more here.
Keywords: negatively regulates; responses deubiquitinating; usp13 negatively; antiviral responses ... See more keywords
Crispr/Cas9 Mediated Inactivation of Argonaute 2 Reveals its Differential Involvement in Antiviral Responses
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-01050-6
Abstract: RNA silencing constitutes an important antiviral mechanism in plants. Small RNA guided Argonaute proteins fulfill essential role in this process by acting as executors of viral restriction. Plants encode multiple Argonaute proteins of which several… read more here.
Keywords: crispr cas9; antiviral responses; involvement antiviral; cas9 mediated ... See more keywords
Estradiol‐regulated innate antiviral responses of human endometrial stromal fibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.13042
Abstract: The contribution of fibroblasts to innate immune protection of the human female reproductive tract (FRT) against viral pathogens is relatively unknown. read more here.
Keywords: innate antiviral; human endometrial; regulated innate; responses human ... See more keywords
Why aging attenuates antiviral responses
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.358.6369.1397-a
Abstract: Immunology![Figure][1] One of the reasons underlying the elderly's increased susceptibility to flu is elucidated. CREDIT: [ISTOCK.COM][2]/INSTANTS Older adults are more likely to die after influenza A viral infection than younger adults. This is in part… read more here.
Keywords: attenuates antiviral; infection; aging attenuates; antiviral responses ... See more keywords
IFN‐&ggr; Influences Epithelial Antiviral Responses via Histone Methylation of the RIG‐I Promoter
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2016-0392oc
Abstract: Abstract The asthmatic lung is prone to respiratory viral infections that exacerbate the symptoms of the underlying disease. Recent work has suggested that a deficient T‐helper cell type 1 response in early life may lead… read more here.
Keywords: ifn ggr; rig promoter; antiviral responses; ggr ... See more keywords
Modulation of Macrophage Polarization by Viruses: Turning Off/On Host Antiviral Responses
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.839585
Abstract: Macrophages are professional antigen-presenting cells and serve as the first line of defense against invading pathogens. Macrophages are polarized toward the proinflammatory classical (M1) or anti-inflammatory alternative (M2) phenotype upon viral infections. M1-polarized macrophages exert… read more here.
Keywords: macrophage polarization; polarization viruses; modulation macrophage; macrophage ... See more keywords
Zebrafish sirt7 Negatively Regulates Antiviral Responses by Attenuating Phosphorylation of irf3 and irf7 Independent of Its Enzymatic Activity.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of immunology"
DOI: 10.4049/jimmunol.2100318
Abstract: Sirt7 is one member of the sirtuin family proteins with NAD (NAD+)-dependent histone deacetylase activity. In this study, we report that zebrafish sirt7 is induced upon viral infection, and overexpression of sirt7 suppresses cellular antiviral… read more here.
Keywords: zebrafish sirt7; activity; sirt7; phosphorylation irf3 ... See more keywords