Methyltransferase‐Like Protein 14 Attenuates Mitochondrial Antiviral Signaling Protein Expression to Negatively Regulate Antiviral Immunity via N6‐methyladenosine Modification
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Science"
DOI: 10.1002/advs.202100606
Abstract: Abstract Mitochondrial antiviral signaling (MAVS) protein is the core signaling adaptor in the RNA signaling pathway. Thus, appropriate regulation of MAVS expression is essential for antiviral immunity against RNA virus infection. However, the regulation of… read more here.
Keywords: protein; antiviral immunity; antiviral signaling; expression ... See more keywords
Ubiquitination network in the Type I interferon-induced antiviral signaling pathway.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202350384
Abstract: Type I interferon (IFN-I) is the body's first line of defense against pathogen infection. IFN-I can induce cellular antiviral responses and therefore plays a key role in driving antiviral innate and adaptive immunity. Canonical IFN-I… read more here.
Keywords: antiviral signaling; ifn; induced antiviral; type interferon ... See more keywords
Sec13 is a positive regulator of VISA-mediated antiviral signaling
Sign Up to like & getrecommendations! Published in 2018 at "Virus Genes"
DOI: 10.1007/s11262-018-1581-0
Abstract: Viral infection triggers the innate antiviral immune response that rapidly produces type I interferons in most cell types to combat viruses invading. Upon viral infection, the cytoplasmic RNA sensors RIG-I/MDA5 recognize viral RNA, and then… read more here.
Keywords: sec13 positive; visa mediated; antiviral signaling; mediated antiviral ... See more keywords
Black carp TUFM collaborates with NLRX1 to inhibit MAVS-mediated antiviral signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2021.104134
Abstract: TUFM is a mitochondrial protein and serves as a regulator of antiviral signaling; nevertheless, the character of TUFM in teleosts remains unidentified. In this study, TUFM homologue of black carp (Mylopharyngodon piceus) has been characterized… read more here.
Keywords: bctufm; black carp; bcmavs; antiviral signaling ... See more keywords
Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular cell"
DOI: 10.1016/j.molcel.2017.09.035
Abstract: Mitochondrial antiviral signaling platform protein (MAVS) acts as a central hub for RIG-I receptor proximal signal propagation. However, key components in the assembly of the MAVS mitochondrial platform that promote RIG-I mitochondrial localization and optimal… read more here.
Keywords: trim14 ppp6c; whip trim14; rig; ppp6c mitochondrial ... See more keywords
ATF3 negatively regulates cellular antiviral signaling and autophagy in the absence of type I interferons
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-08584-9
Abstract: Stringent regulation of antiviral signaling and cellular autophagy is critical for the host response to virus infection. However, little is known how these cellular processes are regulated in the absence of type I interferon signaling.… read more here.
Keywords: cellular antiviral; antiviral signaling; regulates cellular; absence type ... See more keywords
JMJD6 negatively regulates cytosolic RNA induced antiviral signaling by recruiting RNF5 to promote activated IRF3 K48 ubiquitination
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1009366
Abstract: The negative regulation of antiviral immune responses is essential for the host to maintain homeostasis. Jumonji domain-containing protein 6 (JMJD6) was previously identified with a number of functions during RNA virus infection. Upon viral RNA… read more here.
Keywords: jmjd6; irf3 k48; rna; antiviral signaling ... See more keywords
A Novel Antiviral Protein Derived from Oenanthe javanica: Type I Interferon-Dependent Antiviral Signaling and Its Pharmacological Potential
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12060835
Abstract: Pathogenesis-related (PR) proteins produced in plants play a crucial role in self-defense against microbial attacks. Previously, we have identified a novel PR-1-like protein (OPRP) from Oenanthe javanica and examined its pharmacologic relevance and cell signaling… read more here.
Keywords: oenanthe javanica; dependent antiviral; antiviral signaling; type ... See more keywords
Human Respiratory Syncytial Virus NS 1 Targets TRIM25 to Suppress RIG-I Ubiquitination and Subsequent RIG-I-Mediated Antiviral Signaling
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DOI: 10.3390/v10120716
Abstract: Respiratory syncytial virus (RSV) causes severe acute lower respiratory tract disease. Retinoic acid-inducible gene-I (RIG-I) serves as an innate immune sensor and triggers antiviral responses upon recognizing viral infections including RSV. Since tripartite motif-containing protein… read more here.
Keywords: rig; mediated antiviral; rig ubiquitination; antiviral signaling ... See more keywords
Avian Metapneumovirus Subgroup C Induces Mitochondrial Antiviral Signaling Protein Degradation through the Ubiquitin-Proteasome Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13101990
Abstract: The mitochondrial antiviral signaling (MAVS) protein, a critical adapter, links the upstream recognition of viral RNA to downstream antiviral signal transduction. However, the interaction mechanism between avian metapneumovirus subgroup C (aMPV/C) infection and MAVS remains… read more here.
Keywords: degradation; avian metapneumovirus; antiviral signaling; mavs ... See more keywords