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Published in 2020 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.0c00584
Abstract: In light of the global antimicrobial-resistance crisis, there is an urgent need for novel bacterial targets and antibiotics with novel modes of action. It has been shown that Pseudomonas aeruginosa elastase (LasB) and Clostridium histolyticum…
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Keywords:
aeruginosa elastase;
pseudomonas aeruginosa;
antivirulence;
clostridium ... See more keywords
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Published in 2019 at "Nano letters"
DOI: 10.1021/acs.nanolett.9b01844
Abstract: Infections caused by multidrug-resistant Gram-negative bacteria have emerged as a major threat to public health worldwide. The high mortality and prevalence, along with the slow pace of new antibiotic discovery, highlight the necessity for new…
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Keywords:
antivirulence;
gram negative;
negative bacteria;
multiantigenic nanotoxoids ... See more keywords
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Published in 2017 at "Nature Reviews Drug Discovery"
DOI: 10.1038/nrd.2017.23
Abstract: The rapid evolution and dissemination of antibiotic resistance among bacterial pathogens are outpacing the development of new antibiotics, but antivirulence agents provide an alternative. These agents can circumvent antibiotic resistance by disarming pathogens of virulence…
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Keywords:
different drugs;
drugs bad;
antivirulence;
antivirulence strategies ... See more keywords
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Published in 2019 at "Nature Chemical Biology"
DOI: 10.1038/s41589-019-0401-8
Abstract: Staphylococcus aureus is the leading cause of infections worldwide, and methicillin-resistant strains (MRSA) are emerging. New strategies are urgently needed to overcome this threat. Using a cell-based screen of ~45,000 diverse synthetic compounds, we discovered…
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Keywords:
reverses lactam;
antivirulence;
virulence;
lactam resistance ... See more keywords
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Published in 2022 at "Microbial drug resistance"
DOI: 10.1089/mdr.2022.0134
Abstract: Pseudomonas aeruginosa is an opportunistic pathogen that causes several serious health problems and numerous forms of virulence. During the treatment of P. aeruginosa infections, the development of multidrug-resistant isolates creates significant clinical problems. Using antivirulence…
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Keywords:
pao1;
antivirulence;
pseudomonas aeruginosa;
biofilm formation ... See more keywords
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Published in 2019 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2019.00049
Abstract: The rise in antibiotic resistance among bacterial pathogens has prompted the exploitation of alternative antibacterial strategies, such as antivirulence therapy. By inhibiting virulence traits, antivirulence drugs are expected to lessen pathogenicity without affecting bacterial growth,…
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Keywords:
pseudomonas aeruginosa;
antivirulence;
effect;
resistance ... See more keywords
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Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.980217
Abstract: Antivirulence strategy has been developed as a nontraditional therapy which would engender a lower evolutionary pressure toward the development of antimicrobial resistance. However, the majority of the antivirulence agents currently in development could not meet…
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Keywords:
system;
antivirulence;
spectrum antivirulence;
spectrum ... See more keywords
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Published in 2021 at "Antibiotics"
DOI: 10.3390/antibiotics10040363
Abstract: Proteus mirabilis is a frequent cause of catheter associated urinary tract infections (CAUTIs). Several virulence factors contribute to its pathogenesis, but swarming motility, biofilm formation, and urease activity are considered the hallmarks. The increased prevalence…
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Keywords:
antivirulence;
indole derivatives;
proteus mirabilis;
soil ... See more keywords
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Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11060819
Abstract: Staphylococcus aureus can cause a plethora of life-threatening infections. Antibiotics have been extensively used to treat S. aureus infections. However, when antibiotics are used at sub-inhibitory concentrations, especially for β-lactam antibiotics, they may enhance staphylococcal…
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Keywords:
antivirulence;
agent adjuvant;
antivirulence agent;
m21 ... See more keywords
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Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10051169
Abstract: The development of bacterial resistance to traditional antibiotics constitutes an emerging public health issue. Promising approaches have been innovated to conquer bacterial resistance, and targeting bacterial virulence is one of these approaches. Bacterial virulence mitigation…
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Keywords:
anti activities;
antivirulence;
activities gliptins;
quorum sensing ... See more keywords